TY - JOUR
T1 - Fine-mapping identifies multiple prostate cancer risk loci at 5p15, one of which associates with TERT expression
AU - Kote-Jarai, Zsofia
AU - Saunders, Edward J.
AU - Leongamornlert, Daniel A.
AU - Tymrakiewicz, Malgorzata
AU - Dadaev, Tokhir
AU - Jugurn-Little, Sarah
AU - Ross-Adams, Helen
AU - Al Olama, Ali Amin
AU - Benlloch, Sara
AU - Halim, Silvia
AU - COGS-CRUK GWAS-ELLIPSE (Part of GAME-ON) Initiative
AU - The UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons’ Section of Oncology
AU - The UK Protect Study Collaborators
AU - The PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium
AU - Russel, Roslin
AU - Dunning, Alison M.
AU - Luccarini, Craig
AU - Dennis, Joe
AU - Neal, David E.
AU - Hamdy, Freddie C.
AU - Donovan, Jenny L.
AU - Muir, Ken
AU - Giles, Graham G.
AU - Severi, Gianluca
AU - Wiklund, Fredrik
AU - Gronberg, Henrik
AU - Haiman, Christopher A.
AU - Schumacher, Fredrick
AU - Henderson, Brian E.
AU - Marchand, Loic Le
AU - Lindstrom, Sara
AU - Kraft, Peter
AU - Hunter, David J.
AU - Gapstur, Susan
AU - Chanock, Stephen
AU - Berndt, Sonja I.
AU - Albanes, Demetrius
AU - Andriole, Gerald
AU - Schleutker, Johanna
AU - Weischer, Maren
AU - Canzian, Federico
AU - Riboli, Elio
AU - Key, Tim J.
AU - Travis, Ruth C.
AU - Campa, Daniele
AU - Ingles, Sue A.
AU - John, Esther M.
AU - Hayes, Richard B.
AU - Pharoah, Paul
AU - Khaw, Kay Tee
AU - Stanford, Janet L.
AU - Ostrander, Elaine A.
AU - Signorello, Lisa B.
AU - Thibodeau, Stephen N.
AU - Schaid, Dan
AU - Maier, Christiane
AU - Vogel, Walther
AU - Kibel, Adam S.
AU - Cybulski, Cezary
AU - Lubinski, Jan
AU - Cannon-Albright, Lisa
AU - Brenner, Hermann
AU - Park, Jong Y.
AU - Kaneva, Radka
AU - Batra, Jyotsna
AU - Spurdle, Amanda
AU - Clements, Judith A.
AU - Teixeira, Manuel R.
AU - Govindasami, Koveela
AU - Guy, Michelle
AU - Wilkinson, Rosemary A.
AU - Sawyer, Emma J.
AU - Morgan, Angela
AU - Dicks, Ed
AU - Baynes, Caroline
AU - Conroy, Don
AU - Bojesen, Stig E.
AU - Kaaks, Rudolf
AU - Vincent, Daniel
AU - Bacot, Francois
AU - Tessier, Daniel C.
AU - Easton, Douglas F.
AU - Eeles, Rosalind A.
PY - 2013/1/1
Y1 - 2013/1/1
N2 - Associations between single nucleotide polymorphisms (snps) at 5p15 and multiple cancer types have been reported. we have previously shown evidence for a strong association between prostate cancer (prca) risk and rs2242652 at 5p15, intronic in the telomerase reverse transcriptase (tert) gene that encodes tert. to comprehensively evaluate the association between genetic variation across this region and prca, we performed a fine-mapping analysis by genotyping 134 snps using a custom illumina iselect array or sequenom massarray iplex, followed by imputation of 1094 snps in 22 301 prca cases and 22 320 controls in the practical consortium. multiple stepwise logistic regression analysis identified four signals in the promoter or intronic regions of tert that independently associated with prca risk. gene expression analysis of normal prostate tissue showed evidence that snps within one of these regions also associated with tert expression, providing a potential mechanism for predisposition to disease.
AB - Associations between single nucleotide polymorphisms (snps) at 5p15 and multiple cancer types have been reported. we have previously shown evidence for a strong association between prostate cancer (prca) risk and rs2242652 at 5p15, intronic in the telomerase reverse transcriptase (tert) gene that encodes tert. to comprehensively evaluate the association between genetic variation across this region and prca, we performed a fine-mapping analysis by genotyping 134 snps using a custom illumina iselect array or sequenom massarray iplex, followed by imputation of 1094 snps in 22 301 prca cases and 22 320 controls in the practical consortium. multiple stepwise logistic regression analysis identified four signals in the promoter or intronic regions of tert that independently associated with prca risk. gene expression analysis of normal prostate tissue showed evidence that snps within one of these regions also associated with tert expression, providing a potential mechanism for predisposition to disease.
UR - https://www.scopus.com/pages/publications/84878451270
U2 - 10.1093/hmg/ddt086
DO - 10.1093/hmg/ddt086
M3 - Article
AN - SCOPUS:84878451270
SN - 0964-6906
VL - 22
SP - 2520
EP - 2528
JO - Human Molecular Genetics
JF - Human Molecular Genetics
IS - 12
ER -
SDG 3 Good Health and Well-being