Fibrinogen in traumatic haemorrhage: A narrative review

James Winearls*, Don Campbell, Catherine Hurn, Jeremy Furyk, Glenn Ryan, Melita Trout, James Walsham, Anthony Holley, Megan Shuttleworth, Wayne Dyer, Gerben Keijzers, Jeff Presneill, John F. Fraser, Martin Wullschleger

*Corresponding author for this work

Research output: Contribution to journalReview articleResearchpeer-review

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Abstract

Haemorrhage in the setting of severe trauma is associated with significant morbidity and mortality. There is increasing awareness of the important role fibrinogen plays in traumatic haemorrhage. Fibrinogen levels fall precipitously in severe trauma and the resultant hypofibrinogenaemia is associated with poor outcomes. Hence, it has been postulated that early fibrinogen replacement in severe traumatic haemorrhage may improve outcomes, although, to date there is a paucity of high quality evidence to support this hypothesis. In addition there is controversy regarding the optimal method for fibrinogen supplementation. We review the current evidence regarding the role of fibrinogen in trauma, the rationale behind fibrinogen supplementation and discuss current research.

Original languageEnglish
Pages (from-to)230-242
Number of pages13
JournalInjury
Volume48
Issue number2
DOIs
Publication statusPublished - 1 Feb 2017

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    Winearls, J., Campbell, D., Hurn, C., Furyk, J., Ryan, G., Trout, M., Walsham, J., Holley, A., Shuttleworth, M., Dyer, W., Keijzers, G., Presneill, J., Fraser, J. F., & Wullschleger, M. (2017). Fibrinogen in traumatic haemorrhage: A narrative review. Injury, 48(2), 230-242. https://doi.org/10.1016/j.injury.2016.12.012