Fibrinogen in traumatic haemorrhage: A narrative review

James Winearls; Don Campbell; Catherine Hurn; Jeremy Furyk; Glenn Ryan; Melita Trout; James Walsham; Anthony Holley; Megan Shuttleworth; Wayne Dyer; Gerben Keijzers; Jeff Presneill; John F. Fraser; Martin Wullschleger

doi:10.1016/j.injury.2016.12.012

Fibrinogen in traumatic haemorrhage: A narrative review

James Winearls^*, Don Campbell, Catherine Hurn, Jeremy Furyk, Glenn Ryan, Melita Trout, James Walsham, Anthony Holley, Megan Shuttleworth, Wayne Dyer, Gerben Keijzers, Jeff Presneill, John F. Fraser, Martin Wullschleger

^*Corresponding author for this work

Faculty of Health Sciences & Medicine

Research output: Contribution to journal › Review article › Research › peer-review

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Abstract

Haemorrhage in the setting of severe trauma is associated with significant morbidity and mortality. There is increasing awareness of the important role fibrinogen plays in traumatic haemorrhage. Fibrinogen levels fall precipitously in severe trauma and the resultant hypofibrinogenaemia is associated with poor outcomes. Hence, it has been postulated that early fibrinogen replacement in severe traumatic haemorrhage may improve outcomes, although, to date there is a paucity of high quality evidence to support this hypothesis. In addition there is controversy regarding the optimal method for fibrinogen supplementation. We review the current evidence regarding the role of fibrinogen in trauma, the rationale behind fibrinogen supplementation and discuss current research.

Original language	English
Pages (from-to)	230-242
Number of pages	13
Journal	Injury
Volume	48
Issue number	2
DOIs	https://doi.org/10.1016/j.injury.2016.12.012
Publication status	Published - 1 Feb 2017

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10.1016/j.injury.2016.12.012

Fibrinogen in traumatic haemorrhage: A narrative reviewAccepted author manuscript, 1.64 MBLicence: CC BY-NC-ND

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title = "Fibrinogen in traumatic haemorrhage: A narrative review",

abstract = "Haemorrhage in the setting of severe trauma is associated with significant morbidity and mortality. There is increasing awareness of the important role fibrinogen plays in traumatic haemorrhage. Fibrinogen levels fall precipitously in severe trauma and the resultant hypofibrinogenaemia is associated with poor outcomes. Hence, it has been postulated that early fibrinogen replacement in severe traumatic haemorrhage may improve outcomes, although, to date there is a paucity of high quality evidence to support this hypothesis. In addition there is controversy regarding the optimal method for fibrinogen supplementation. We review the current evidence regarding the role of fibrinogen in trauma, the rationale behind fibrinogen supplementation and discuss current research.",

author = "James Winearls and Don Campbell and Catherine Hurn and Jeremy Furyk and Glenn Ryan and Melita Trout and James Walsham and Anthony Holley and Megan Shuttleworth and Wayne Dyer and Gerben Keijzers and Jeff Presneill and Fraser, {John F.} and Martin Wullschleger",

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AU - Winearls, James

AU - Campbell, Don

AU - Hurn, Catherine

AU - Furyk, Jeremy

AU - Ryan, Glenn

AU - Trout, Melita

AU - Walsham, James

AU - Holley, Anthony

AU - Shuttleworth, Megan

AU - Dyer, Wayne

AU - Keijzers, Gerben

AU - Presneill, Jeff

AU - Fraser, John F.

AU - Wullschleger, Martin

PY - 2017/2/1

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N2 - Haemorrhage in the setting of severe trauma is associated with significant morbidity and mortality. There is increasing awareness of the important role fibrinogen plays in traumatic haemorrhage. Fibrinogen levels fall precipitously in severe trauma and the resultant hypofibrinogenaemia is associated with poor outcomes. Hence, it has been postulated that early fibrinogen replacement in severe traumatic haemorrhage may improve outcomes, although, to date there is a paucity of high quality evidence to support this hypothesis. In addition there is controversy regarding the optimal method for fibrinogen supplementation. We review the current evidence regarding the role of fibrinogen in trauma, the rationale behind fibrinogen supplementation and discuss current research.

AB - Haemorrhage in the setting of severe trauma is associated with significant morbidity and mortality. There is increasing awareness of the important role fibrinogen plays in traumatic haemorrhage. Fibrinogen levels fall precipitously in severe trauma and the resultant hypofibrinogenaemia is associated with poor outcomes. Hence, it has been postulated that early fibrinogen replacement in severe traumatic haemorrhage may improve outcomes, although, to date there is a paucity of high quality evidence to support this hypothesis. In addition there is controversy regarding the optimal method for fibrinogen supplementation. We review the current evidence regarding the role of fibrinogen in trauma, the rationale behind fibrinogen supplementation and discuss current research.

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DO - 10.1016/j.injury.2016.12.012

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SN - 1572-3461

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JO - Injury

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Fibrinogen in traumatic haemorrhage: A narrative review

Abstract

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