Abstract
Although non-steroidal anti-inflammatory drugs are known to cause peptic ulcer and its complications, controversy exists about the number of deaths from ulcer which are attributable to their use. A case-control study was therefore performed to determine whether prior use of non-steroidal and other antiinflammatory compounds was associated with an increased case fatality rate from complications of peptic ulcer. Non-steroidal anti-inflammatory drugs were used by 39% of a series of 80 patients who had died from peptic ulcer complications and by 37% of 160 controls who were survivors matched for sex, age, ulcer site, and nature of complication (odds ratio 1.1; 95% confidence interval 0.6 to 2.1). Similarly, the rates of prior use of aspirin by cases and controls were almost identical (odds ratio 1-2; 95% confidence interval 0. to 1.9). Thus neither non-steroidal anti-inflammatory drugs nor aspirin were associated with increased case fatality rates from peptic ulcer.
Original language | English |
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Pages (from-to) | 1227-1229 |
Number of pages | 3 |
Journal | British Medical Journal (Clinical research ed.) |
Volume | 295 |
Issue number | 6608 |
DOIs | |
Publication status | Published - Nov 1987 |
Externally published | Yes |