Fatal bilateral pneumothoraces following administration of aerosolised pentamidine

Alison Green; Nathan Milne; Beng Beng Ong

doi:10.1016/j.jflm.2011.06.012

Fatal bilateral pneumothoraces following administration of aerosolised pentamidine

Alison Green, Nathan Milne^*, Beng Beng Ong

^*Corresponding author for this work

Faculty of Health Sciences & Medicine

Research output: Contribution to journal › Article › Research › peer-review

4 Citations (Scopus)

Abstract

Aerosolised pentamidine (AP) is used for prophylaxis against infection with Pneumocystis jiroveci (carinii), a significant cause of morbidity and mortality for people with human immunodeficiency virus (HIV). In this article we report a 55 year old man with HIV and a background history of asthma since childhood, who suffered respiratory arrest and died within an hour of commencing AP prophylaxis. Autopsy revealed bilateral pneumothoraces. Common side effects of AP therapy include bronchospasm and coughing. Pneumothorax has been reported in several cases. To our knowledge, this is the first reported fatality from bilateral pneumothoraces. (C) 2011 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.

Original language	English
Pages (from-to)	332-335
Number of pages	4
Journal	Journal of Forensic and Legal Medicine
Volume	18
Issue number	7
DOIs	https://doi.org/10.1016/j.jflm.2011.06.012
Publication status	Published - Oct 2011

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title = "Fatal bilateral pneumothoraces following administration of aerosolised pentamidine",

abstract = "Aerosolised pentamidine (AP) is used for prophylaxis against infection with Pneumocystis jiroveci (carinii), a significant cause of morbidity and mortality for people with human immunodeficiency virus (HIV). In this article we report a 55 year old man with HIV and a background history of asthma since childhood, who suffered respiratory arrest and died within an hour of commencing AP prophylaxis. Autopsy revealed bilateral pneumothoraces. Common side effects of AP therapy include bronchospasm and coughing. Pneumothorax has been reported in several cases. To our knowledge, this is the first reported fatality from bilateral pneumothoraces. (C) 2011 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.",

author = "Alison Green and Nathan Milne and Ong, {Beng Beng}",

year = "2011",

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doi = "10.1016/j.jflm.2011.06.012",

language = "English",

volume = "18",

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journal = "Journal of Forensic and Legal Medicine",

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T1 - Fatal bilateral pneumothoraces following administration of aerosolised pentamidine

AU - Green, Alison

AU - Milne, Nathan

AU - Ong, Beng Beng

PY - 2011/10

Y1 - 2011/10

N2 - Aerosolised pentamidine (AP) is used for prophylaxis against infection with Pneumocystis jiroveci (carinii), a significant cause of morbidity and mortality for people with human immunodeficiency virus (HIV). In this article we report a 55 year old man with HIV and a background history of asthma since childhood, who suffered respiratory arrest and died within an hour of commencing AP prophylaxis. Autopsy revealed bilateral pneumothoraces. Common side effects of AP therapy include bronchospasm and coughing. Pneumothorax has been reported in several cases. To our knowledge, this is the first reported fatality from bilateral pneumothoraces. (C) 2011 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.

AB - Aerosolised pentamidine (AP) is used for prophylaxis against infection with Pneumocystis jiroveci (carinii), a significant cause of morbidity and mortality for people with human immunodeficiency virus (HIV). In this article we report a 55 year old man with HIV and a background history of asthma since childhood, who suffered respiratory arrest and died within an hour of commencing AP prophylaxis. Autopsy revealed bilateral pneumothoraces. Common side effects of AP therapy include bronchospasm and coughing. Pneumothorax has been reported in several cases. To our knowledge, this is the first reported fatality from bilateral pneumothoraces. (C) 2011 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.

U2 - 10.1016/j.jflm.2011.06.012

DO - 10.1016/j.jflm.2011.06.012

M3 - Article

SN - 1752-928X

VL - 18

SP - 332

EP - 335

JO - Journal of Forensic and Legal Medicine

JF - Journal of Forensic and Legal Medicine

IS - 7

ER -

Fatal bilateral pneumothoraces following administration of aerosolised pentamidine

Abstract

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