Family history of premature CHD and risk factor control in patients with a recent ACS

Daniel Yu-Hung Jeng; Haeri Min; Simone Marschner; Desi Quitans; Julie Redfern; Harry Klimis; Graham S. Hillis; David B. Brieger; John J. Atherton; Ravinay Bhindi; Derek P. Chew; Nicholas Collins; Michael Andrew Fitzpatrick; Craig P. Juergens; Nadarajah Kangaharan; Andrew Maiorana; Michele McGrady; Rohan Poulter; Pratap Shetty; Christian Hamilton-Craig; Peter Thompson; Sandrine Stepien; Amy Von Huben; Jansen Shirley; Clara K. Chow

doi:10.1038/s44325-025-00060-y

Family history of premature CHD and risk factor control in patients with a recent ACS

Daniel Yu-Hung Jeng, Haeri Min, Simone Marschner, Desi Quitans, Julie Redfern, Harry Klimis, Graham S. Hillis, David B. Brieger, John J. Atherton, Ravinay Bhindi, Derek P. Chew, Nicholas Collins, Michael Andrew Fitzpatrick, Craig P. Juergens, Nadarajah Kangaharan, Andrew Maiorana, Michele McGrady, Rohan Poulter, Pratap Shetty, Christian Hamilton-CraigPeter Thompson, Sandrine Stepien, Amy Von Huben, Jansen Shirley, Clara K. Chow

Research output: Contribution to journal › Article › Research › peer-review

Abstract

Individuals with a family history of premature coronary heart disease (CHD) have increased cardiac morbidity and mortality, which may motivate them to modify their health behaviours. This analysis examines whether patients with self-reported family history of premature CHD experiencing an acute coronary syndrome (ACS) were more likely to have their risk factors and health behaviours under control at 12 months post ACS. Data from the TEXTMEDS study were used to estimate the association between self-reported family history of premature CHD and blood pressure control, LDL cholesterol control, BMI, exercise and smoking status at 12 months post ACS. The study cohort consisted of 1423 participants (mean age 58.0 ± 10.67, 79.2% male), with 556 (39.1%) reporting a family history of premature CHD, while 867 (60.9%) reported no family history. No evidence from this analysis suggests that patients with knowledge of their family history were more likely to achieve better risk factor control. Novel strategies for risk factor control in this high-risk population is required to improve secondary prevention.

Original language	English
Article number	37
Pages (from-to)	1-7
Number of pages	7
Journal	NPJ cardiovascular health
Volume	2
DOIs	https://doi.org/10.1038/s44325-025-00060-y
Publication status	Published - 15 Jul 2025
Externally published	Yes

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Effects of a Nurse-Avatar Guided Discharge Education Smartphone Application in People After Acute Coronary Syndrome: A Randomised Controlled Trial
Ellis, T., Cheng, S., Zecchin, R., Redfern, J., Hyun, K., Marks, D., Zhang, L., Gallagher, R. & Clark, R., Aug 2025, In: Heart, Lung and Circulation. 34, Supplement 4, p. S491-S492 2 p.
Research output: Contribution to journal › Meeting Abstract › Research › peer-review

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Jeng, D. Y.-H., Min, H., Marschner, S., Quitans, D., Redfern, J., Klimis, H., Hillis, G. S., Brieger, D. B., Atherton, J. J., Bhindi, R., Chew, D. P., Collins, N., Andrew Fitzpatrick, M., Juergens, C. P., Kangaharan, N., Maiorana, A., McGrady, M., Poulter, R., Shetty, P., ... Chow, C. K. (2025). Family history of premature CHD and risk factor control in patients with a recent ACS. NPJ cardiovascular health, 2, 1-7. Article 37. https://doi.org/10.1038/s44325-025-00060-y

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title = "Family history of premature CHD and risk factor control in patients with a recent ACS",

abstract = "Individuals with a family history of premature coronary heart disease (CHD) have increased cardiac morbidity and mortality, which may motivate them to modify their health behaviours. This analysis examines whether patients with self-reported family history of premature CHD experiencing an acute coronary syndrome (ACS) were more likely to have their risk factors and health behaviours under control at 12 months post ACS. Data from the TEXTMEDS study were used to estimate the association between self-reported family history of premature CHD and blood pressure control, LDL cholesterol control, BMI, exercise and smoking status at 12 months post ACS. The study cohort consisted of 1423 participants (mean age 58.0 ± 10.67, 79.2% male), with 556 (39.1%) reporting a family history of premature CHD, while 867 (60.9%) reported no family history. No evidence from this analysis suggests that patients with knowledge of their family history were more likely to achieve better risk factor control. Novel strategies for risk factor control in this high-risk population is required to improve secondary prevention.",

author = "Jeng, {Daniel Yu-Hung} and Haeri Min and Simone Marschner and Desi Quitans and Julie Redfern and Harry Klimis and Hillis, {Graham S.} and Brieger, {David B.} and Atherton, {John J.} and Ravinay Bhindi and Chew, {Derek P.} and Nicholas Collins and {Andrew Fitzpatrick}, Michael and Juergens, {Craig P.} and Nadarajah Kangaharan and Andrew Maiorana and Michele McGrady and Rohan Poulter and Pratap Shetty and Christian Hamilton-Craig and Peter Thompson and Sandrine Stepien and {Von Huben}, Amy and Jansen Shirley and Chow, {Clara K.}",

year = "2025",

month = jul,

day = "15",

doi = "10.1038/s44325-025-00060-y",

language = "English",

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Jeng, DY-H, Min, H, Marschner, S, Quitans, D, Redfern, J, Klimis, H, Hillis, GS, Brieger, DB, Atherton, JJ, Bhindi, R, Chew, DP, Collins, N, Andrew Fitzpatrick, M, Juergens, CP, Kangaharan, N, Maiorana, A, McGrady, M, Poulter, R, Shetty, P, Hamilton-Craig, C, Thompson, P, Stepien, S, Von Huben, A, Shirley, J & Chow, CK 2025, 'Family history of premature CHD and risk factor control in patients with a recent ACS', NPJ cardiovascular health, vol. 2, 37, pp. 1-7. https://doi.org/10.1038/s44325-025-00060-y

TY - JOUR

T1 - Family history of premature CHD and risk factor control in patients with a recent ACS

AU - Jeng, Daniel Yu-Hung

AU - Min, Haeri

AU - Marschner, Simone

AU - Quitans, Desi

AU - Redfern, Julie

AU - Klimis, Harry

AU - Hillis, Graham S.

AU - Brieger, David B.

AU - Atherton, John J.

AU - Bhindi, Ravinay

AU - Chew, Derek P.

AU - Collins, Nicholas

AU - Andrew Fitzpatrick, Michael

AU - Juergens, Craig P.

AU - Kangaharan, Nadarajah

AU - Maiorana, Andrew

AU - McGrady, Michele

AU - Poulter, Rohan

AU - Shetty, Pratap

AU - Hamilton-Craig, Christian

AU - Thompson, Peter

AU - Stepien, Sandrine

AU - Von Huben, Amy

AU - Shirley, Jansen

AU - Chow, Clara K.

PY - 2025/7/15

Y1 - 2025/7/15

N2 - Individuals with a family history of premature coronary heart disease (CHD) have increased cardiac morbidity and mortality, which may motivate them to modify their health behaviours. This analysis examines whether patients with self-reported family history of premature CHD experiencing an acute coronary syndrome (ACS) were more likely to have their risk factors and health behaviours under control at 12 months post ACS. Data from the TEXTMEDS study were used to estimate the association between self-reported family history of premature CHD and blood pressure control, LDL cholesterol control, BMI, exercise and smoking status at 12 months post ACS. The study cohort consisted of 1423 participants (mean age 58.0 ± 10.67, 79.2% male), with 556 (39.1%) reporting a family history of premature CHD, while 867 (60.9%) reported no family history. No evidence from this analysis suggests that patients with knowledge of their family history were more likely to achieve better risk factor control. Novel strategies for risk factor control in this high-risk population is required to improve secondary prevention.

AB - Individuals with a family history of premature coronary heart disease (CHD) have increased cardiac morbidity and mortality, which may motivate them to modify their health behaviours. This analysis examines whether patients with self-reported family history of premature CHD experiencing an acute coronary syndrome (ACS) were more likely to have their risk factors and health behaviours under control at 12 months post ACS. Data from the TEXTMEDS study were used to estimate the association between self-reported family history of premature CHD and blood pressure control, LDL cholesterol control, BMI, exercise and smoking status at 12 months post ACS. The study cohort consisted of 1423 participants (mean age 58.0 ± 10.67, 79.2% male), with 556 (39.1%) reporting a family history of premature CHD, while 867 (60.9%) reported no family history. No evidence from this analysis suggests that patients with knowledge of their family history were more likely to achieve better risk factor control. Novel strategies for risk factor control in this high-risk population is required to improve secondary prevention.

U2 - 10.1038/s44325-025-00060-y

DO - 10.1038/s44325-025-00060-y

M3 - Article

SN - 2948-2836

VL - 2

SP - 1

EP - 7

JO - NPJ cardiovascular health

JF - NPJ cardiovascular health

M1 - 37

ER -

Family history of premature CHD and risk factor control in patients with a recent ACS

Abstract

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Effects of a Nurse-Avatar Guided Discharge Education Smartphone Application in People After Acute Coronary Syndrome: A Randomised Controlled Trial

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