TY - JOUR
T1 - Factors underlying cognitive decline in old age and Alzheimer's disease: The role of the hippocampus
AU - Jaroudi, Wafa
AU - Garami, Julia
AU - Garrido, Sandra
AU - Hornberger, Michael
AU - Keri, Szabolcs
AU - Moustafa, Ahmed A.
N1 - De Gruyter allows authors the use of the final published version of an article (publisher pdf) for self-archiving (author's personal website) and/or archiving in an institutional repository (on a non-profit server) after an embargo period of 12 months after publication.
PY - 2017/10/26
Y1 - 2017/10/26
N2 - There are many factors that strongly influence the aetiology, development, and progression of cognitive decline in old age, mild cognitive impairment (MCI), and Alzheimer's disease (AD). These factors include not only different personality traits and moods but also lifestyle patterns (e.g. exercise and diet) and awareness levels that lead to cognitive decline in old age. In this review, we discuss how personality traits, mood states, and lifestyle impact brain and behaviour in older adults. Specifically, our review shows that these lifestyle and personality factors affect several brain regions, including the hippocampus, a region key for memory that is affected by cognitive decline in old age as well as AD. Accordingly, appropriate recommendations are presented in this review to assist individuals in decreasing chances of MCI, dementia, AD, and associated symptoms.
AB - There are many factors that strongly influence the aetiology, development, and progression of cognitive decline in old age, mild cognitive impairment (MCI), and Alzheimer's disease (AD). These factors include not only different personality traits and moods but also lifestyle patterns (e.g. exercise and diet) and awareness levels that lead to cognitive decline in old age. In this review, we discuss how personality traits, mood states, and lifestyle impact brain and behaviour in older adults. Specifically, our review shows that these lifestyle and personality factors affect several brain regions, including the hippocampus, a region key for memory that is affected by cognitive decline in old age as well as AD. Accordingly, appropriate recommendations are presented in this review to assist individuals in decreasing chances of MCI, dementia, AD, and associated symptoms.
UR - http://www.scopus.com/inward/record.url?scp=85027574470&partnerID=8YFLogxK
U2 - 10.1515/revneuro-2016-0086
DO - 10.1515/revneuro-2016-0086
M3 - Article
C2 - 28422707
AN - SCOPUS:85027574470
SN - 0334-1763
VL - 28
SP - 705
EP - 714
JO - Reviews in the Neurosciences
JF - Reviews in the Neurosciences
IS - 7
ER -