Extramedullary hematopoiesis leading to the production of a novel antigen-presenting cell type in murine spleen

Rebecca A Hinton, Helen C O'Neill

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

Abstract

The concept of extramedullary hematopoiesis for production of organ-specific antigen presenting cells has importance in immunity in terms of the compartmentalisation of the immune response in different tissue sites. A new and distinct dendritic-like antigen presenting cell subtype is described which is dependent on the spleen microenvironment for development. Cells arise by a unique developmental pathway distinct from other dendritic cells (DC). In particular, a self-renewing progenitor of these cells has been identified in spleen upstream of the earliest DC progenitor currently identified in bone marrow. This progenitor depends on the splenic microenvironment for maintenance and proliferation, adding further support for spleen as a site for hematopoiesis.
Original languageEnglish
Title of host publicationHematopoietic Stem Cells
Subtitle of host publicationNew Research
EditorsW. G. Montgomery, H. L. Burton
Place of PublicationUnited States
PublisherNova Science Publishers
Chapter6
Pages151-164
Number of pages14
ISBN (Print)978-1-62257-468-1
Publication statusPublished - 2012
Externally publishedYes

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Extramedullary Hematopoiesis
Antigen-Presenting Cells
Spleen
Dendritic Cells
Hematopoiesis
Immunity
Stem Cells
Bone Marrow
Maintenance

Cite this

Hinton, R. A., & O'Neill, H. C. (2012). Extramedullary hematopoiesis leading to the production of a novel antigen-presenting cell type in murine spleen. In W. G. Montgomery, & H. L. Burton (Eds.), Hematopoietic Stem Cells: New Research (pp. 151-164). United States: Nova Science Publishers.
Hinton, Rebecca A ; O'Neill, Helen C. / Extramedullary hematopoiesis leading to the production of a novel antigen-presenting cell type in murine spleen. Hematopoietic Stem Cells: New Research. editor / W. G. Montgomery ; H. L. Burton. United States : Nova Science Publishers, 2012. pp. 151-164
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Hinton, RA & O'Neill, HC 2012, Extramedullary hematopoiesis leading to the production of a novel antigen-presenting cell type in murine spleen. in WG Montgomery & HL Burton (eds), Hematopoietic Stem Cells: New Research. Nova Science Publishers, United States, pp. 151-164.

Extramedullary hematopoiesis leading to the production of a novel antigen-presenting cell type in murine spleen. / Hinton, Rebecca A; O'Neill, Helen C.

Hematopoietic Stem Cells: New Research. ed. / W. G. Montgomery; H. L. Burton. United States : Nova Science Publishers, 2012. p. 151-164.

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

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AB - The concept of extramedullary hematopoiesis for production of organ-specific antigen presenting cells has importance in immunity in terms of the compartmentalisation of the immune response in different tissue sites. A new and distinct dendritic-like antigen presenting cell subtype is described which is dependent on the spleen microenvironment for development. Cells arise by a unique developmental pathway distinct from other dendritic cells (DC). In particular, a self-renewing progenitor of these cells has been identified in spleen upstream of the earliest DC progenitor currently identified in bone marrow. This progenitor depends on the splenic microenvironment for maintenance and proliferation, adding further support for spleen as a site for hematopoiesis.

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Hinton RA, O'Neill HC. Extramedullary hematopoiesis leading to the production of a novel antigen-presenting cell type in murine spleen. In Montgomery WG, Burton HL, editors, Hematopoietic Stem Cells: New Research. United States: Nova Science Publishers. 2012. p. 151-164