Extramedullary hematopoiesis leading to the production of a novel antigen-presenting cell type in murine spleen

Rebecca A Hinton, Helen C O'Neill

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Abstract

The concept of extramedullary hematopoiesis for production of organ-specific antigen presenting cells has importance in immunity in terms of the compartmentalisation of the immune response in different tissue sites. A new and distinct dendritic-like antigen presenting cell subtype is described which is dependent on the spleen microenvironment for development. Cells arise by a unique developmental pathway distinct from other dendritic cells (DC). In particular, a self-renewing progenitor of these cells has been identified in spleen upstream of the earliest DC progenitor currently identified in bone marrow. This progenitor depends on the splenic microenvironment for maintenance and proliferation, adding further support for spleen as a site for hematopoiesis.

Original languageEnglish
Pages (from-to)199-208
Number of pages10
JournalJournal of Stem Cells
Volume9
Issue number3
Publication statusPublished - 2014
Externally publishedYes

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Extramedullary Hematopoiesis
Antigen-Presenting Cells
Spleen
Dendritic Cells
Hematopoiesis
Immunity
Stem Cells
Bone Marrow
Maintenance

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abstract = "The concept of extramedullary hematopoiesis for production of organ-specific antigen presenting cells has importance in immunity in terms of the compartmentalisation of the immune response in different tissue sites. A new and distinct dendritic-like antigen presenting cell subtype is described which is dependent on the spleen microenvironment for development. Cells arise by a unique developmental pathway distinct from other dendritic cells (DC). In particular, a self-renewing progenitor of these cells has been identified in spleen upstream of the earliest DC progenitor currently identified in bone marrow. This progenitor depends on the splenic microenvironment for maintenance and proliferation, adding further support for spleen as a site for hematopoiesis.",
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Extramedullary hematopoiesis leading to the production of a novel antigen-presenting cell type in murine spleen. / Hinton, Rebecca A; O'Neill, Helen C.

In: Journal of Stem Cells, Vol. 9, No. 3, 2014, p. 199-208.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Extramedullary hematopoiesis leading to the production of a novel antigen-presenting cell type in murine spleen

AU - Hinton, Rebecca A

AU - O'Neill, Helen C

PY - 2014

Y1 - 2014

N2 - The concept of extramedullary hematopoiesis for production of organ-specific antigen presenting cells has importance in immunity in terms of the compartmentalisation of the immune response in different tissue sites. A new and distinct dendritic-like antigen presenting cell subtype is described which is dependent on the spleen microenvironment for development. Cells arise by a unique developmental pathway distinct from other dendritic cells (DC). In particular, a self-renewing progenitor of these cells has been identified in spleen upstream of the earliest DC progenitor currently identified in bone marrow. This progenitor depends on the splenic microenvironment for maintenance and proliferation, adding further support for spleen as a site for hematopoiesis.

AB - The concept of extramedullary hematopoiesis for production of organ-specific antigen presenting cells has importance in immunity in terms of the compartmentalisation of the immune response in different tissue sites. A new and distinct dendritic-like antigen presenting cell subtype is described which is dependent on the spleen microenvironment for development. Cells arise by a unique developmental pathway distinct from other dendritic cells (DC). In particular, a self-renewing progenitor of these cells has been identified in spleen upstream of the earliest DC progenitor currently identified in bone marrow. This progenitor depends on the splenic microenvironment for maintenance and proliferation, adding further support for spleen as a site for hematopoiesis.

M3 - Article

VL - 9

SP - 199

EP - 208

JO - Journal of Stem Cells

JF - Journal of Stem Cells

SN - 1556-8539

IS - 3

ER -