TY - JOUR
T1 - Extracellular vesicles: Emerging mediators of cell communication in gastrointestinal cancers exhibiting metabolic abnormalities
AU - Pourali, Ghazaleh
AU - Zafari, Nima
AU - Fiuji, Hamid
AU - Batra, Jyotsna
AU - Nazari, Elham
AU - Khazaei, Majid
AU - Hassanian, Seyed Mahdi
AU - Vahabi, Mahrou
AU - Kiani, Mohammad Ali
AU - Ghayour-Mobarhan, Majid
AU - Peters, Godefridus J.
AU - Ferns, Gordon A.
AU - Lam, Alfred King yin
AU - Giovannetti, Elisa
AU - Avan, Amir
PY - 2023/10/1
Y1 - 2023/10/1
N2 - There is a complex interaction between pro-tumoural and anti-tumoural networks in the tumour microenvironment (TME). Throughout tumourigenesis, communication between malignant cells and various cells of the TME contributes to metabolic reprogramming. Tumour Dysregulation of metabolic pathways offer an evolutional advantage in the TME and enhance the tumour progression, invasiveness, and metastasis. Therefore, understanding these interactions within the TME is crucial for the development of innovative cancer treatments. Extracellular vesicles (EVs) serve as carriers of various materials that include microRNAs, proteins, and lipids that play a vital role in the communication between tumour cells and non-tumour cells. EVs are actively involved in the metabolic reprogramming process. This review summarized recent findings regarding the involvement of EVs in the metabolic reprogramming of various cells in the TME of gastrointestinal cancers. Additionally, we highlight identified microRNAs involved in the reprogramming process in this group of cancers and explained the abnormal tumour metabolism targeted by exosomal cargos as well as the novel potential therapeutic approaches.
AB - There is a complex interaction between pro-tumoural and anti-tumoural networks in the tumour microenvironment (TME). Throughout tumourigenesis, communication between malignant cells and various cells of the TME contributes to metabolic reprogramming. Tumour Dysregulation of metabolic pathways offer an evolutional advantage in the TME and enhance the tumour progression, invasiveness, and metastasis. Therefore, understanding these interactions within the TME is crucial for the development of innovative cancer treatments. Extracellular vesicles (EVs) serve as carriers of various materials that include microRNAs, proteins, and lipids that play a vital role in the communication between tumour cells and non-tumour cells. EVs are actively involved in the metabolic reprogramming process. This review summarized recent findings regarding the involvement of EVs in the metabolic reprogramming of various cells in the TME of gastrointestinal cancers. Additionally, we highlight identified microRNAs involved in the reprogramming process in this group of cancers and explained the abnormal tumour metabolism targeted by exosomal cargos as well as the novel potential therapeutic approaches.
UR - http://www.scopus.com/inward/record.url?scp=85168352278&partnerID=8YFLogxK
U2 - 10.1016/j.cytogfr.2023.08.001
DO - 10.1016/j.cytogfr.2023.08.001
M3 - Review article
C2 - 37573251
AN - SCOPUS:85168352278
SN - 1359-6101
VL - 73
SP - 101
EP - 113
JO - Cytokine and Growth Factor Reviews
JF - Cytokine and Growth Factor Reviews
ER -
