Exosomes: Mechanisms of Uptake

Kelly J McKelvey, Katie L Powell, Anthony W Ashton, Jonathan M Morris, Sharon A McCracken

Research output: Contribution to journalReview articleResearchpeer-review

64 Citations (Scopus)
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Abstract

Exosomes are 30-100 nm microvesicles which contain complex cellular signals of RNA, protein and lipids. Because of this, exosomes are implicated as having limitless therapeutic potential for the treatment of cancer, pregnancy complications, infections, and autoimmune diseases. To date we know a considerable amount about exosome biogenesis and secretion, but there is a paucity of data regarding the uptake of exosomes by immune and non-immune cell types (e.g., cancer cells) and the internal signalling pathways by which these exosomes elicit a cellular response. Answering these questions is of paramount importance.

Original languageEnglish
Article number7
Number of pages9
JournalJournal of Circulating Biomarkers
Volume4
DOIs
Publication statusPublished - 2015
Externally publishedYes

Fingerprint

Exosomes
Cells
RNA
Lipids
Proteins
Pregnancy Complications
Autoimmune Diseases
Neoplasms
Infection

Cite this

McKelvey, K. J., Powell, K. L., Ashton, A. W., Morris, J. M., & McCracken, S. A. (2015). Exosomes: Mechanisms of Uptake. Journal of Circulating Biomarkers, 4, [7]. https://doi.org/10.5772/61186
McKelvey, Kelly J ; Powell, Katie L ; Ashton, Anthony W ; Morris, Jonathan M ; McCracken, Sharon A. / Exosomes: Mechanisms of Uptake. In: Journal of Circulating Biomarkers. 2015 ; Vol. 4.
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McKelvey, KJ, Powell, KL, Ashton, AW, Morris, JM & McCracken, SA 2015, 'Exosomes: Mechanisms of Uptake' Journal of Circulating Biomarkers, vol. 4, 7. https://doi.org/10.5772/61186

Exosomes: Mechanisms of Uptake. / McKelvey, Kelly J; Powell, Katie L; Ashton, Anthony W; Morris, Jonathan M; McCracken, Sharon A.

In: Journal of Circulating Biomarkers, Vol. 4, 7, 2015.

Research output: Contribution to journalReview articleResearchpeer-review

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