Exosomes: Mechanisms of Uptake

Kelly J McKelvey, Katie L Powell, Anthony W Ashton, Jonathan M Morris, Sharon A McCracken

Research output: Contribution to journalReview articleResearchpeer-review

320 Citations (Scopus)
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Exosomes are 30-100 nm microvesicles which contain complex cellular signals of RNA, protein and lipids. Because of this, exosomes are implicated as having limitless therapeutic potential for the treatment of cancer, pregnancy complications, infections, and autoimmune diseases. To date we know a considerable amount about exosome biogenesis and secretion, but there is a paucity of data regarding the uptake of exosomes by immune and non-immune cell types (e.g., cancer cells) and the internal signalling pathways by which these exosomes elicit a cellular response. Answering these questions is of paramount importance.

Original languageEnglish
Article number7
Number of pages9
JournalJournal of Circulating Biomarkers
Publication statusPublished - 2015
Externally publishedYes


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