Exosomes: Mechanisms of Uptake

Kelly J McKelvey; Katie L Powell; Anthony W Ashton; Jonathan M Morris; Sharon A McCracken

doi:10.5772/61186

Exosomes: Mechanisms of Uptake

Kelly J McKelvey, Katie L Powell, Anthony W Ashton, Jonathan M Morris, Sharon A McCracken

Research output: Contribution to journal › Review article › Research › peer-review

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Abstract

Exosomes are 30-100 nm microvesicles which contain complex cellular signals of RNA, protein and lipids. Because of this, exosomes are implicated as having limitless therapeutic potential for the treatment of cancer, pregnancy complications, infections, and autoimmune diseases. To date we know a considerable amount about exosome biogenesis and secretion, but there is a paucity of data regarding the uptake of exosomes by immune and non-immune cell types (e.g., cancer cells) and the internal signalling pathways by which these exosomes elicit a cellular response. Answering these questions is of paramount importance.

Original language	English
Article number	7
Number of pages	9
Journal	Journal of Circulating Biomarkers
Volume	4
DOIs	https://doi.org/10.5772/61186
Publication status	Published - 2015
Externally published	Yes

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Exosomes: Mechanisms of UptakeFinal published version, 496 KBLicence: CC BY

Cite this

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author = "McKelvey, {Kelly J} and Powell, {Katie L} and Ashton, {Anthony W} and Morris, {Jonathan M} and McCracken, {Sharon A}",

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AU - Ashton, Anthony W

AU - Morris, Jonathan M

AU - McCracken, Sharon A

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N2 - Exosomes are 30-100 nm microvesicles which contain complex cellular signals of RNA, protein and lipids. Because of this, exosomes are implicated as having limitless therapeutic potential for the treatment of cancer, pregnancy complications, infections, and autoimmune diseases. To date we know a considerable amount about exosome biogenesis and secretion, but there is a paucity of data regarding the uptake of exosomes by immune and non-immune cell types (e.g., cancer cells) and the internal signalling pathways by which these exosomes elicit a cellular response. Answering these questions is of paramount importance.

AB - Exosomes are 30-100 nm microvesicles which contain complex cellular signals of RNA, protein and lipids. Because of this, exosomes are implicated as having limitless therapeutic potential for the treatment of cancer, pregnancy complications, infections, and autoimmune diseases. To date we know a considerable amount about exosome biogenesis and secretion, but there is a paucity of data regarding the uptake of exosomes by immune and non-immune cell types (e.g., cancer cells) and the internal signalling pathways by which these exosomes elicit a cellular response. Answering these questions is of paramount importance.

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JF - Journal of Circulating Biomarkers

SN - 1849-4544

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Exosomes: Mechanisms of Uptake

Abstract

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