Evidence of depression-associated circadian rhythm disruption and regret in prostate cancer patients after surgery

Joanne Christie, Christopher F. Sharpley, Vicki Bitsika, David Christie

    Research output: Contribution to journalArticleResearchpeer-review

    Abstract

    Purpose: The purpose of this study is to investigate the association between prostate cancer (PCa) patients’ regret that their surgery harmed them, and their scores on the two key symptoms of major depressive disorder (depressed mood, anhedonia) and a symptom of melancholic depression (disruption to circadian rhythm). Methods: Forty PCa patients who had received surgery for their PCa completed a postal survey including background information, regret about surgery that ‘did them a lot of harm’ and three items drawn from the Zung Self-Rating Depression Scale measuring depressed mood, anhedonia and circadian rhythm disruption. Results: There were significant correlations between all three symptoms of depression (depressed mood, anhedonia, disruption to circadian rhythm) and between patients’ regret that surgery did them a lot of harm and their circadian rhythm disruption, but not between depressed mood or anhedonia and regret about surgery doing harm. Conclusions: These findings suggest that PCa patients’ post-surgery regrets about major harm may lead to a significant disruption in a central physiological function and raise the need to consider this side effect of surgery when planning supportive services for these men.

    Original languageEnglish
    Pages (from-to)3603-3605
    Number of pages3
    JournalSupportive Care in Cancer
    Volume25
    Issue number12
    Early online date4 Oct 2017
    DOIs
    Publication statusPublished - Dec 2017

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    Circadian Rhythm
    Prostatic Neoplasms
    Emotions
    Anhedonia
    Depression
    Major Depressive Disorder

    Cite this

    Christie, Joanne ; Sharpley, Christopher F. ; Bitsika, Vicki ; Christie, David. / Evidence of depression-associated circadian rhythm disruption and regret in prostate cancer patients after surgery. In: Supportive Care in Cancer. 2017 ; Vol. 25, No. 12. pp. 3603-3605.
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    abstract = "Purpose: The purpose of this study is to investigate the association between prostate cancer (PCa) patients’ regret that their surgery harmed them, and their scores on the two key symptoms of major depressive disorder (depressed mood, anhedonia) and a symptom of melancholic depression (disruption to circadian rhythm). Methods: Forty PCa patients who had received surgery for their PCa completed a postal survey including background information, regret about surgery that ‘did them a lot of harm’ and three items drawn from the Zung Self-Rating Depression Scale measuring depressed mood, anhedonia and circadian rhythm disruption. Results: There were significant correlations between all three symptoms of depression (depressed mood, anhedonia, disruption to circadian rhythm) and between patients’ regret that surgery did them a lot of harm and their circadian rhythm disruption, but not between depressed mood or anhedonia and regret about surgery doing harm. Conclusions: These findings suggest that PCa patients’ post-surgery regrets about major harm may lead to a significant disruption in a central physiological function and raise the need to consider this side effect of surgery when planning supportive services for these men.",
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    Evidence of depression-associated circadian rhythm disruption and regret in prostate cancer patients after surgery. / Christie, Joanne; Sharpley, Christopher F.; Bitsika, Vicki; Christie, David.

    In: Supportive Care in Cancer, Vol. 25, No. 12, 12.2017, p. 3603-3605.

    Research output: Contribution to journalArticleResearchpeer-review

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    AB - Purpose: The purpose of this study is to investigate the association between prostate cancer (PCa) patients’ regret that their surgery harmed them, and their scores on the two key symptoms of major depressive disorder (depressed mood, anhedonia) and a symptom of melancholic depression (disruption to circadian rhythm). Methods: Forty PCa patients who had received surgery for their PCa completed a postal survey including background information, regret about surgery that ‘did them a lot of harm’ and three items drawn from the Zung Self-Rating Depression Scale measuring depressed mood, anhedonia and circadian rhythm disruption. Results: There were significant correlations between all three symptoms of depression (depressed mood, anhedonia, disruption to circadian rhythm) and between patients’ regret that surgery did them a lot of harm and their circadian rhythm disruption, but not between depressed mood or anhedonia and regret about surgery doing harm. Conclusions: These findings suggest that PCa patients’ post-surgery regrets about major harm may lead to a significant disruption in a central physiological function and raise the need to consider this side effect of surgery when planning supportive services for these men.

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