Evaluation of 13 rapidly mutating Y-STRs on a Dravidian pedigree

S. Iyavoo; R. Alghafri; R. Almheiri; T. Haizel

doi:10.1016/j.fsigss.2019.09.083

Evaluation of 13 rapidly mutating Y-STRs on a Dravidian pedigree

S. Iyavoo^*, R. Alghafri, R. Almheiri, T. Haizel

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

Abstract

The effectiveness of a rapidly mutating Y-STRs multiplex assay (RM Y-STRs) containing 13 RM Y-STR markers was compared with the AmpFℓSTR™ Yfiler™ PCR Amplification Kit (Yfiler) with conventional Y-STR markers for their efficiency in differentiating males within the same paternal lineage. Samples from 4 generations comprising 16 Dravidian males (15 father-son pairs) were analysed with both assays. Mutations were observed in 3 father-son pairs in the RM Y-STRs profiles while only 2 mutations were observed in the Y-filer profiles. Even though not many mutations were observed as anticipated, this study still emphasised the importance of RM Y-STRs when differentiation between males within the same paternal lineage is required and also indicated the need for mutation rates for different populations.

Original language	English
Pages (from-to)	216-217
Number of pages	2
Journal	Forensic Science International: Genetics Supplement Series
Volume	7
Issue number	1
Early online date	26 Sept 2019
DOIs	https://doi.org/10.1016/j.fsigss.2019.09.083
Publication status	Published - 1 Dec 2019
Externally published	Yes

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title = "Evaluation of 13 rapidly mutating Y-STRs on a Dravidian pedigree",

abstract = "The effectiveness of a rapidly mutating Y-STRs multiplex assay (RM Y-STRs) containing 13 RM Y-STR markers was compared with the AmpFℓSTR{\texttrademark} Yfiler{\texttrademark} PCR Amplification Kit (Yfiler) with conventional Y-STR markers for their efficiency in differentiating males within the same paternal lineage. Samples from 4 generations comprising 16 Dravidian males (15 father-son pairs) were analysed with both assays. Mutations were observed in 3 father-son pairs in the RM Y-STRs profiles while only 2 mutations were observed in the Y-filer profiles. Even though not many mutations were observed as anticipated, this study still emphasised the importance of RM Y-STRs when differentiation between males within the same paternal lineage is required and also indicated the need for mutation rates for different populations.",

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AB - The effectiveness of a rapidly mutating Y-STRs multiplex assay (RM Y-STRs) containing 13 RM Y-STR markers was compared with the AmpFℓSTR™ Yfiler™ PCR Amplification Kit (Yfiler) with conventional Y-STR markers for their efficiency in differentiating males within the same paternal lineage. Samples from 4 generations comprising 16 Dravidian males (15 father-son pairs) were analysed with both assays. Mutations were observed in 3 father-son pairs in the RM Y-STRs profiles while only 2 mutations were observed in the Y-filer profiles. Even though not many mutations were observed as anticipated, this study still emphasised the importance of RM Y-STRs when differentiation between males within the same paternal lineage is required and also indicated the need for mutation rates for different populations.

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Evaluation of 13 rapidly mutating Y-STRs on a Dravidian pedigree

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