Evaluating a novel behavioral paradigm for visual hallucinations in Dementia with Lewy bodies

Joseph R. Phillips; Elie Matar; Kaylena A. Ehgoetz Martens; Ahmed A. Moustafa; Glenda M. Halliday; Simon J.G. Lewis

doi:10.1016/j.nbas.2021.100011

Evaluating a novel behavioral paradigm for visual hallucinations in Dementia with Lewy bodies

Joseph R. Phillips
, Elie Matar
, Kaylena A. Ehgoetz Martens
, Ahmed A. Moustafa
, Glenda M. Halliday
, Simon J.G. Lewis^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

6 Citations (Scopus)

Abstract

The aim of this study was to evaluate the utility of the Bistable Percept Paradigm (BPP), a computerised behavioural task that has previously been utilised for the assessment of visual hallucinations in Parkinson's Disease, in a Dementia with Lewy bodies (DLB) cohort. Dementia with Lewy bodies patients demonstrated poorer performance than healthy controls (HC) on the BPP with significantly more misperceptions and a greater failure to detect bistable percepts correctly compared to HC. Further, the number of misperceptions was also correlated with the severity of hallucinations. The findings from this study demonstrate that the BPP is a viable tool to measure misperceptions in DLB patients.

Original language	English
Article number	100011
Pages (from-to)	1-8
Number of pages	8
Journal	Aging Brain
Volume	1
DOIs	https://doi.org/10.1016/j.nbas.2021.100011
Publication status	Published - Jan 2021
Externally published	Yes

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title = "Evaluating a novel behavioral paradigm for visual hallucinations in Dementia with Lewy bodies",

abstract = "The aim of this study was to evaluate the utility of the Bistable Percept Paradigm (BPP), a computerised behavioural task that has previously been utilised for the assessment of visual hallucinations in Parkinson's Disease, in a Dementia with Lewy bodies (DLB) cohort. Dementia with Lewy bodies patients demonstrated poorer performance than healthy controls (HC) on the BPP with significantly more misperceptions and a greater failure to detect bistable percepts correctly compared to HC. Further, the number of misperceptions was also correlated with the severity of hallucinations. The findings from this study demonstrate that the BPP is a viable tool to measure misperceptions in DLB patients.",

author = "Phillips, \{Joseph R.\} and Elie Matar and \{Ehgoetz Martens\}, \{Kaylena A.\} and Moustafa, \{Ahmed A.\} and Halliday, \{Glenda M.\} and Lewis, \{Simon J.G.\}",

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AU - Phillips, Joseph R.

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AU - Ehgoetz Martens, Kaylena A.

AU - Moustafa, Ahmed A.

AU - Halliday, Glenda M.

AU - Lewis, Simon J.G.

PY - 2021/1

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N2 - The aim of this study was to evaluate the utility of the Bistable Percept Paradigm (BPP), a computerised behavioural task that has previously been utilised for the assessment of visual hallucinations in Parkinson's Disease, in a Dementia with Lewy bodies (DLB) cohort. Dementia with Lewy bodies patients demonstrated poorer performance than healthy controls (HC) on the BPP with significantly more misperceptions and a greater failure to detect bistable percepts correctly compared to HC. Further, the number of misperceptions was also correlated with the severity of hallucinations. The findings from this study demonstrate that the BPP is a viable tool to measure misperceptions in DLB patients.

AB - The aim of this study was to evaluate the utility of the Bistable Percept Paradigm (BPP), a computerised behavioural task that has previously been utilised for the assessment of visual hallucinations in Parkinson's Disease, in a Dementia with Lewy bodies (DLB) cohort. Dementia with Lewy bodies patients demonstrated poorer performance than healthy controls (HC) on the BPP with significantly more misperceptions and a greater failure to detect bistable percepts correctly compared to HC. Further, the number of misperceptions was also correlated with the severity of hallucinations. The findings from this study demonstrate that the BPP is a viable tool to measure misperceptions in DLB patients.

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VL - 1

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JO - Aging Brain

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M1 - 100011

ER -

Evaluating a novel behavioral paradigm for visual hallucinations in Dementia with Lewy bodies

Abstract

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