Ethical priorities for international collaborative adaptive platform trials for public health emergencies

Katharine Wright; Joseph Ali; Alun Davies; Paul Glasziou; Nina Gobat; Tanja Kuchenmüller; Katherine Littler; Chelsea Modlin; Lee-Anne Pascoe; Andreas Reis; Jerome Amir Singh

doi:10.1136/bmjgh-2023-012930

Ethical priorities for international collaborative adaptive platform trials for public health emergencies

Katharine Wright, Joseph Ali, Alun Davies, Paul Glasziou, Nina Gobat, Tanja Kuchenmüller, Katherine Littler, Chelsea Modlin, Lee-Anne Pascoe, Andreas Reis, Jerome Amir Singh

Institute for Evidence-Based Healthcare

Research output: Contribution to journal › Comment/debate/opinion › Research › peer-review

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Abstract

Rapidly produced evidence on effective medical counter measures is critical for responding to health emergencies caused by (re-)emerging infectious diseases.

Adaptive platform trials played a significant role in the global research response to COVID-19 and are likely to be increasingly used in the future, both in emergency and non-emergency contexts.

We call attention to a number of ethical considerations that should influence the development and future implementation of large-scale multicountry adaptive platform studies.

Original language	English
Article number	e012930
Pages (from-to)	1-4
Number of pages	4
Journal	BMJ Global Health
Volume	8
Issue number	7
DOIs	https://doi.org/10.1136/bmjgh-2023-012930
Publication status	Published - 31 Jul 2023

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10.1136/bmjgh-2023-012930Licence: CC BY-NC

Ethical priorities for international collaborative adaptive platform trials for public health emergenciesFinal published version, 525 KBLicence: CC BY-NC

Cite this

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title = "Ethical priorities for international collaborative adaptive platform trials for public health emergencies",

abstract = "Rapidly produced evidence on effective medical counter measures is critical for responding to health emergencies caused by (re-)emerging infectious diseases.Adaptive platform trials played a significant role in the global research response to COVID-19 and are likely to be increasingly used in the future, both in emergency and non-emergency contexts.We call attention to a number of ethical considerations that should influence the development and future implementation of large-scale multicountry adaptive platform studies.",

author = "Katharine Wright and Joseph Ali and Alun Davies and Paul Glasziou and Nina Gobat and Tanja Kuchenm{\"u}ller and Katherine Littler and Chelsea Modlin and Lee-Anne Pascoe and Andreas Reis and Singh, {Jerome Amir}",

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T1 - Ethical priorities for international collaborative adaptive platform trials for public health emergencies

AU - Wright, Katharine

AU - Ali, Joseph

AU - Davies, Alun

AU - Glasziou, Paul

AU - Gobat, Nina

AU - Kuchenmüller, Tanja

AU - Littler, Katherine

AU - Modlin, Chelsea

AU - Pascoe, Lee-Anne

AU - Reis, Andreas

AU - Singh, Jerome Amir

N1 - Funding Information: This work was supported by the Wellcome Trust (214711, https://doi.org/10.35802/214711and221719 , https://doi.org/10.35802/221719 ).

PY - 2023/7/31

Y1 - 2023/7/31

N2 - Rapidly produced evidence on effective medical counter measures is critical for responding to health emergencies caused by (re-)emerging infectious diseases.Adaptive platform trials played a significant role in the global research response to COVID-19 and are likely to be increasingly used in the future, both in emergency and non-emergency contexts.We call attention to a number of ethical considerations that should influence the development and future implementation of large-scale multicountry adaptive platform studies.

AB - Rapidly produced evidence on effective medical counter measures is critical for responding to health emergencies caused by (re-)emerging infectious diseases.Adaptive platform trials played a significant role in the global research response to COVID-19 and are likely to be increasingly used in the future, both in emergency and non-emergency contexts.We call attention to a number of ethical considerations that should influence the development and future implementation of large-scale multicountry adaptive platform studies.

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JO - BMJ Global Health

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Ethical priorities for international collaborative adaptive platform trials for public health emergencies

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