Establishing a dose-response relationship between acute resistance-exercise and the immune system: Protocol for a systematic review

Adam Michael Szlezak, Siri Lauluten Szlezak, James Keane, Lotti Tajouri, Clare Minahan

Research output: Contribution to journalReview articleResearchpeer-review

5 Citations (Scopus)

Abstract

Exercise immunology research has traditionally focussed on aerobic-exercise, however it has become apparent in more recent years that resistance-exercise can also considerably affect host immunobiology. To date however, no systematic process has been used to establish a dose-response relationship between resistance-exercise and the immune system. The present systematic review was thus conducted to determine the dose-response effects of a bout of resistance-exercise on acute leukocyte counts. In accordance with the PRISMA guidelines, a systematic literature search was conducted in the electronic databases, PubMed, Web of Science, and Google Scholar, over the date range of 1989–2016. Following the PICO elements, eligibility criteria included: i) participants: healthy humans aged 18–40; ii) intervention: a single bout of resistance-exercise; iii) comparator: at least one comparator group; iv) outcome: acute measures of circulating leukocyte counts. Specific exclusion criteria were also applied. Risk of bias and quality of evidence was assessed using the PEDro scale. Due to the individual designs of the admitted studies, a qualitative analysis (systematic narrative synthesis) was employed in the present review. The results of the present review demonstrate that a single bout of resistance-exercise induces an acute monocytosis, neutrophilia, and lymphocytosis. It became apparent that the reviewed literature either does not consistently specify, or does not describe with sufficient detail, the time-course between the onset of exercise and the collection of blood. We recommend that researchers consider addressing this in future studies, and also collect blood measures during exercise to aid with comparison of temporal effects. Regarding the determination of a dose-response relationship, an acute neutrophilia, monocytosis and lymphocytosis appears to occur more rapidly and to a greater magnitude following a single bout of high-dose vs low-dose resistance-exercise. Mechanistically, exercise-induced cell trafficking changes are associated with mechanical, metabolic and endocrine factors. Physical aptitude of the host may also affect resistance-exercise-induced lymphocyte trafficking responses.

Original languageEnglish
Pages (from-to)54-65
Number of pages12
JournalImmunology Letters
Volume180
DOIs
Publication statusPublished - 1 Dec 2016

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Immune System
Exercise
Lymphocytosis
Leukocyte Count
Allergy and Immunology
PubMed
Healthy Volunteers
Research Personnel
Outcome Assessment (Health Care)
Databases
Guidelines
Lymphocytes

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Szlezak, Adam Michael ; Szlezak, Siri Lauluten ; Keane, James ; Tajouri, Lotti ; Minahan, Clare. / Establishing a dose-response relationship between acute resistance-exercise and the immune system: Protocol for a systematic review. In: Immunology Letters. 2016 ; Vol. 180. pp. 54-65.
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Establishing a dose-response relationship between acute resistance-exercise and the immune system: Protocol for a systematic review. / Szlezak, Adam Michael; Szlezak, Siri Lauluten; Keane, James; Tajouri, Lotti; Minahan, Clare.

In: Immunology Letters, Vol. 180, 01.12.2016, p. 54-65.

Research output: Contribution to journalReview articleResearchpeer-review

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AU - Szlezak, Adam Michael

AU - Szlezak, Siri Lauluten

AU - Keane, James

AU - Tajouri, Lotti

AU - Minahan, Clare

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AB - Exercise immunology research has traditionally focussed on aerobic-exercise, however it has become apparent in more recent years that resistance-exercise can also considerably affect host immunobiology. To date however, no systematic process has been used to establish a dose-response relationship between resistance-exercise and the immune system. The present systematic review was thus conducted to determine the dose-response effects of a bout of resistance-exercise on acute leukocyte counts. In accordance with the PRISMA guidelines, a systematic literature search was conducted in the electronic databases, PubMed, Web of Science, and Google Scholar, over the date range of 1989–2016. Following the PICO elements, eligibility criteria included: i) participants: healthy humans aged 18–40; ii) intervention: a single bout of resistance-exercise; iii) comparator: at least one comparator group; iv) outcome: acute measures of circulating leukocyte counts. Specific exclusion criteria were also applied. Risk of bias and quality of evidence was assessed using the PEDro scale. Due to the individual designs of the admitted studies, a qualitative analysis (systematic narrative synthesis) was employed in the present review. The results of the present review demonstrate that a single bout of resistance-exercise induces an acute monocytosis, neutrophilia, and lymphocytosis. It became apparent that the reviewed literature either does not consistently specify, or does not describe with sufficient detail, the time-course between the onset of exercise and the collection of blood. We recommend that researchers consider addressing this in future studies, and also collect blood measures during exercise to aid with comparison of temporal effects. Regarding the determination of a dose-response relationship, an acute neutrophilia, monocytosis and lymphocytosis appears to occur more rapidly and to a greater magnitude following a single bout of high-dose vs low-dose resistance-exercise. Mechanistically, exercise-induced cell trafficking changes are associated with mechanical, metabolic and endocrine factors. Physical aptitude of the host may also affect resistance-exercise-induced lymphocyte trafficking responses.

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DO - 10.1016/j.imlet.2016.10.010

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JF - Immunology Letters

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