Efficacy of ginger (Zingiber officinale) in ameliorating chemotherapy-induced nausea and vomiting and chemotherapy-related outcomes: a systematic literature review update and meta-analysis

Megan Crichton, Skye Marshall, Wolfgang Marx, Elisabeth Isenring

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Abstract

IntroductionGinger has long been used in traditional medicine for alleviating nausea and vomiting; however, its use as an adjutant therapy in patients undergoing chemotherapy is under-researched. ObjectivesA systematic literature review and meta-analysis was undertaken to evaluate the efficacy of ginger supplementation in the prevention and management of chemotherapy-induced nausea and vomiting.MethodsFive electronic databases were searched from database inception to October 2017. Intervention studies which administered ginger supplementation and a control (placebo or anti-emetic) to adults receiving chemotherapy were included, critically appraised using the Cochrane Risk of Bias tool, and pooled using meta-analysis. Results Seventeen papers were included. Ginger supplementation of any dose or duration had no significant effect on nausea incidence or severity. Ginger administration for >3-days significantly reduced overall vomiting incidence(OR:0.58 [95%CI:0.38-0.90] P=0.01; n=5 studies; I2=74%) and delayed-phase vomiting incidence (OR:0.44 [95%CI:0.25-0.78]P=0.005; n=3 studies; n=239 participants; I2=83%). Sensitivity analysis did not explain the substantial heterogeneity in the pooled outcomes.ConclusionsGinger supplementation for >3-days may improve chemotherapy induced vomiting incidence; however, existing research remains inconsistent. Further research using strong designs, adequate sample sizes and standardized ginger products is warranted prior to routine clinical prescription.
Original languageEnglish
Article numbereP242
Pages (from-to)S168
JournalSupportive Care in Cancer
Volume26
Issue numberS2
DOIs
Publication statusPublished - Jun 2018
EventMultinational Association of Supportive Care in Cancer (MASCC) and the International Society of Oral Oncology (ISOO): MASCC/ISOO 2018 Annual Meeting on Supportive Care in Cancer - Vienna, Austria
Duration: 28 Jun 201830 Jun 2018
https://masccmeeting.org/2018#.XLwQPugzaUk

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Ginger
Nausea
Vomiting
Meta-Analysis
Drug Therapy
Incidence
Databases
Antiemetics
Traditional Medicine
Research
Sample Size
Prescriptions
Placebos

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@article{024358ab17c74d51b47bceb28c4e3ad6,
title = "Efficacy of ginger (Zingiber officinale) in ameliorating chemotherapy-induced nausea and vomiting and chemotherapy-related outcomes: a systematic literature review update and meta-analysis",
abstract = "IntroductionGinger has long been used in traditional medicine for alleviating nausea and vomiting; however, its use as an adjutant therapy in patients undergoing chemotherapy is under-researched. ObjectivesA systematic literature review and meta-analysis was undertaken to evaluate the efficacy of ginger supplementation in the prevention and management of chemotherapy-induced nausea and vomiting.MethodsFive electronic databases were searched from database inception to October 2017. Intervention studies which administered ginger supplementation and a control (placebo or anti-emetic) to adults receiving chemotherapy were included, critically appraised using the Cochrane Risk of Bias tool, and pooled using meta-analysis. Results Seventeen papers were included. Ginger supplementation of any dose or duration had no significant effect on nausea incidence or severity. Ginger administration for >3-days significantly reduced overall vomiting incidence(OR:0.58 [95{\%}CI:0.38-0.90] P=0.01; n=5 studies; I2=74{\%}) and delayed-phase vomiting incidence (OR:0.44 [95{\%}CI:0.25-0.78]P=0.005; n=3 studies; n=239 participants; I2=83{\%}). Sensitivity analysis did not explain the substantial heterogeneity in the pooled outcomes.ConclusionsGinger supplementation for >3-days may improve chemotherapy induced vomiting incidence; however, existing research remains inconsistent. Further research using strong designs, adequate sample sizes and standardized ginger products is warranted prior to routine clinical prescription.",
author = "Megan Crichton and Skye Marshall and Wolfgang Marx and Elisabeth Isenring",
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doi = "10.1007/s00520-018-4193-2",
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Efficacy of ginger (Zingiber officinale) in ameliorating chemotherapy-induced nausea and vomiting and chemotherapy-related outcomes: a systematic literature review update and meta-analysis. / Crichton, Megan; Marshall, Skye; Marx, Wolfgang; Isenring, Elisabeth.

In: Supportive Care in Cancer, Vol. 26, No. S2, eP242, 06.2018, p. S168.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

TY - JOUR

T1 - Efficacy of ginger (Zingiber officinale) in ameliorating chemotherapy-induced nausea and vomiting and chemotherapy-related outcomes: a systematic literature review update and meta-analysis

AU - Crichton, Megan

AU - Marshall, Skye

AU - Marx, Wolfgang

AU - Isenring, Elisabeth

PY - 2018/6

Y1 - 2018/6

N2 - IntroductionGinger has long been used in traditional medicine for alleviating nausea and vomiting; however, its use as an adjutant therapy in patients undergoing chemotherapy is under-researched. ObjectivesA systematic literature review and meta-analysis was undertaken to evaluate the efficacy of ginger supplementation in the prevention and management of chemotherapy-induced nausea and vomiting.MethodsFive electronic databases were searched from database inception to October 2017. Intervention studies which administered ginger supplementation and a control (placebo or anti-emetic) to adults receiving chemotherapy were included, critically appraised using the Cochrane Risk of Bias tool, and pooled using meta-analysis. Results Seventeen papers were included. Ginger supplementation of any dose or duration had no significant effect on nausea incidence or severity. Ginger administration for >3-days significantly reduced overall vomiting incidence(OR:0.58 [95%CI:0.38-0.90] P=0.01; n=5 studies; I2=74%) and delayed-phase vomiting incidence (OR:0.44 [95%CI:0.25-0.78]P=0.005; n=3 studies; n=239 participants; I2=83%). Sensitivity analysis did not explain the substantial heterogeneity in the pooled outcomes.ConclusionsGinger supplementation for >3-days may improve chemotherapy induced vomiting incidence; however, existing research remains inconsistent. Further research using strong designs, adequate sample sizes and standardized ginger products is warranted prior to routine clinical prescription.

AB - IntroductionGinger has long been used in traditional medicine for alleviating nausea and vomiting; however, its use as an adjutant therapy in patients undergoing chemotherapy is under-researched. ObjectivesA systematic literature review and meta-analysis was undertaken to evaluate the efficacy of ginger supplementation in the prevention and management of chemotherapy-induced nausea and vomiting.MethodsFive electronic databases were searched from database inception to October 2017. Intervention studies which administered ginger supplementation and a control (placebo or anti-emetic) to adults receiving chemotherapy were included, critically appraised using the Cochrane Risk of Bias tool, and pooled using meta-analysis. Results Seventeen papers were included. Ginger supplementation of any dose or duration had no significant effect on nausea incidence or severity. Ginger administration for >3-days significantly reduced overall vomiting incidence(OR:0.58 [95%CI:0.38-0.90] P=0.01; n=5 studies; I2=74%) and delayed-phase vomiting incidence (OR:0.44 [95%CI:0.25-0.78]P=0.005; n=3 studies; n=239 participants; I2=83%). Sensitivity analysis did not explain the substantial heterogeneity in the pooled outcomes.ConclusionsGinger supplementation for >3-days may improve chemotherapy induced vomiting incidence; however, existing research remains inconsistent. Further research using strong designs, adequate sample sizes and standardized ginger products is warranted prior to routine clinical prescription.

U2 - 10.1007/s00520-018-4193-2

DO - 10.1007/s00520-018-4193-2

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SP - S168

JO - Supportive Care in Cancer

JF - Supportive Care in Cancer

SN - 0941-4355

IS - S2

M1 - eP242

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