Efficacy of α-lactalbumin and milk protein on weight loss and body composition during energy restriction

Stijn Soenen, Ananda Hochstenbach-Waelen, Margriet S. Westerterp-Plantenga

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Abstract

Our objective was to examine whether elevated α-lactalbumin (αlac) protein intake compared to elevated supra sustained milk protein (SSP) and sustained milk protein (SP) intake results into a difference in body weight and body composition over a 6-month energy-restriction intervention. Body weight, body composition, resting energy expenditure (REE), satiety and blood- and urine-parameters of 87 subjects (BMI 31 5kg/m 2 and fat percentage 40 8%) were assessed before and after daily energy intakes of 100, 33, and 67% for 1, 1, and 2 months respectively (periods 1, 2, and 3), with protein intake from meal replacements and 2 months of 67% with ad libitum protein intake additional to the meal replacements (period 4). The diets resulted in 0.8 0.3g/kg body mass (BM) for SP and significant higher protein intake (24-h nitrogen) of 1.2 0.3 and 1.0 0.3g/kgBM for SSP and αlac (P 0.05). Body weight and fat percentage was decreased in all groups after 6 months (SP 7 5kg and 5 3%; SSP 6 3kg and 5 3%; αlac 6 4kg and 4 4%, P 0.001; there was no significant group by time difference). Furthermore, sparing of fat-free mass (FFM) and preservation of REE in function of FFM during weight loss was not significantly different between the αlac-group and the SSP- and SP-groups. In conclusion, the efficacy of αlac in reduction of body weight and fat mass (FM), and preservation of FFM does not differ from the efficacy of similar daily intakes of milk protein during 6 months of energy restriction.

Original languageEnglish
Pages (from-to)370-379
Number of pages10
JournalObesity
Volume19
Issue number2
DOIs
Publication statusPublished - 1 Feb 2011
Externally publishedYes

Fingerprint

Lactalbumin
Milk Proteins
Body Composition
Weight Loss
Fats
Body Weight
Energy Metabolism
Meals
Adipose Tissue
Proteins
Energy Intake
Nitrogen
Urine
Diet

Cite this

Soenen, Stijn ; Hochstenbach-Waelen, Ananda ; Westerterp-Plantenga, Margriet S. / Efficacy of α-lactalbumin and milk protein on weight loss and body composition during energy restriction. In: Obesity. 2011 ; Vol. 19, No. 2. pp. 370-379.
@article{31a9e26cee42439087169d4478b2306f,
title = "Efficacy of α-lactalbumin and milk protein on weight loss and body composition during energy restriction",
abstract = "Our objective was to examine whether elevated α-lactalbumin (αlac) protein intake compared to elevated supra sustained milk protein (SSP) and sustained milk protein (SP) intake results into a difference in body weight and body composition over a 6-month energy-restriction intervention. Body weight, body composition, resting energy expenditure (REE), satiety and blood- and urine-parameters of 87 subjects (BMI 31 5kg/m 2 and fat percentage 40 8{\%}) were assessed before and after daily energy intakes of 100, 33, and 67{\%} for 1, 1, and 2 months respectively (periods 1, 2, and 3), with protein intake from meal replacements and 2 months of 67{\%} with ad libitum protein intake additional to the meal replacements (period 4). The diets resulted in 0.8 0.3g/kg body mass (BM) for SP and significant higher protein intake (24-h nitrogen) of 1.2 0.3 and 1.0 0.3g/kgBM for SSP and αlac (P 0.05). Body weight and fat percentage was decreased in all groups after 6 months (SP 7 5kg and 5 3{\%}; SSP 6 3kg and 5 3{\%}; αlac 6 4kg and 4 4{\%}, P 0.001; there was no significant group by time difference). Furthermore, sparing of fat-free mass (FFM) and preservation of REE in function of FFM during weight loss was not significantly different between the αlac-group and the SSP- and SP-groups. In conclusion, the efficacy of αlac in reduction of body weight and fat mass (FM), and preservation of FFM does not differ from the efficacy of similar daily intakes of milk protein during 6 months of energy restriction.",
author = "Stijn Soenen and Ananda Hochstenbach-Waelen and Westerterp-Plantenga, {Margriet S.}",
year = "2011",
month = "2",
day = "1",
doi = "10.1038/oby.2010.146",
language = "English",
volume = "19",
pages = "370--379",
journal = "Obesity Research",
issn = "1071-7323",
publisher = "Wiley-Blackwell",
number = "2",

}

Efficacy of α-lactalbumin and milk protein on weight loss and body composition during energy restriction. / Soenen, Stijn; Hochstenbach-Waelen, Ananda; Westerterp-Plantenga, Margriet S.

In: Obesity, Vol. 19, No. 2, 01.02.2011, p. 370-379.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Efficacy of α-lactalbumin and milk protein on weight loss and body composition during energy restriction

AU - Soenen, Stijn

AU - Hochstenbach-Waelen, Ananda

AU - Westerterp-Plantenga, Margriet S.

PY - 2011/2/1

Y1 - 2011/2/1

N2 - Our objective was to examine whether elevated α-lactalbumin (αlac) protein intake compared to elevated supra sustained milk protein (SSP) and sustained milk protein (SP) intake results into a difference in body weight and body composition over a 6-month energy-restriction intervention. Body weight, body composition, resting energy expenditure (REE), satiety and blood- and urine-parameters of 87 subjects (BMI 31 5kg/m 2 and fat percentage 40 8%) were assessed before and after daily energy intakes of 100, 33, and 67% for 1, 1, and 2 months respectively (periods 1, 2, and 3), with protein intake from meal replacements and 2 months of 67% with ad libitum protein intake additional to the meal replacements (period 4). The diets resulted in 0.8 0.3g/kg body mass (BM) for SP and significant higher protein intake (24-h nitrogen) of 1.2 0.3 and 1.0 0.3g/kgBM for SSP and αlac (P 0.05). Body weight and fat percentage was decreased in all groups after 6 months (SP 7 5kg and 5 3%; SSP 6 3kg and 5 3%; αlac 6 4kg and 4 4%, P 0.001; there was no significant group by time difference). Furthermore, sparing of fat-free mass (FFM) and preservation of REE in function of FFM during weight loss was not significantly different between the αlac-group and the SSP- and SP-groups. In conclusion, the efficacy of αlac in reduction of body weight and fat mass (FM), and preservation of FFM does not differ from the efficacy of similar daily intakes of milk protein during 6 months of energy restriction.

AB - Our objective was to examine whether elevated α-lactalbumin (αlac) protein intake compared to elevated supra sustained milk protein (SSP) and sustained milk protein (SP) intake results into a difference in body weight and body composition over a 6-month energy-restriction intervention. Body weight, body composition, resting energy expenditure (REE), satiety and blood- and urine-parameters of 87 subjects (BMI 31 5kg/m 2 and fat percentage 40 8%) were assessed before and after daily energy intakes of 100, 33, and 67% for 1, 1, and 2 months respectively (periods 1, 2, and 3), with protein intake from meal replacements and 2 months of 67% with ad libitum protein intake additional to the meal replacements (period 4). The diets resulted in 0.8 0.3g/kg body mass (BM) for SP and significant higher protein intake (24-h nitrogen) of 1.2 0.3 and 1.0 0.3g/kgBM for SSP and αlac (P 0.05). Body weight and fat percentage was decreased in all groups after 6 months (SP 7 5kg and 5 3%; SSP 6 3kg and 5 3%; αlac 6 4kg and 4 4%, P 0.001; there was no significant group by time difference). Furthermore, sparing of fat-free mass (FFM) and preservation of REE in function of FFM during weight loss was not significantly different between the αlac-group and the SSP- and SP-groups. In conclusion, the efficacy of αlac in reduction of body weight and fat mass (FM), and preservation of FFM does not differ from the efficacy of similar daily intakes of milk protein during 6 months of energy restriction.

UR - http://www.scopus.com/inward/record.url?scp=79551505272&partnerID=8YFLogxK

U2 - 10.1038/oby.2010.146

DO - 10.1038/oby.2010.146

M3 - Article

VL - 19

SP - 370

EP - 379

JO - Obesity Research

JF - Obesity Research

SN - 1071-7323

IS - 2

ER -