Projects per year
Methods: PubMed, Embase, CINAHL, and CENTRAL were searched for randomised controlled trials until 27 April 2020. Outcomes were GIS, inflammatory and oxidative stress markers, QoL, and adverse events. The Cochrane Risk of Bias tool and GRADE were used to appraise studies. Data were pooled using Revman.
Results: Twenty-three trials in CD, UC, and IBS patients were included. Compared with placebo, biophenol-rich nutraceuticals improved GIS (SMD: 0.43 [95%CI: 0.22, 0.63]; GRADE: very low) in UC, CD, and IBS participants. In UC and CD participants, biophenol-rich nutraceuticals improved CRP by 1.6 mg/L [95%CI:0.08, 3.11; GRADE: low], malondialdehyde by 1 mmol/L [95%CI:0.55, 1.38; GRADE: low]; but only resveratrol improved QoL (SMD: -0.84 [95%CI: -1.24, -0.44; GRADE: high). Resveratrol (for UC and CD participants) and peppermint oil (for IBS participants) had greater certainty in the evidence for improving GIS and QoL (GRADE: moderate to high). There was no effect on adverse events (P > .05).
Conclusions: Biophenol-rich nutraceuticals may be an effective and safe adjuvant treatment for the management of CD, UC, and IBS; with higher certainty of evidence for resveratrol for UC and CD and peppermint oil for IBS.
Isenring, E., Marshall, S., Reidlinger, D., Kelly, J., Cox, G., Van der Meij, B., MacKenzie-Shalders, K., Mayr, H., Dahl, C., Crichton, M., O'Bryan, K. R., Norris, R., Warner, M., Davidson, A., Naranjo, A., Mahoney, S., Eberhardt, F., Dalwood, P., Lopez, E., Hofto, S., Innerarity, C., So, D., McIntosh, A., Gadd, N., Chan, H. C. (., Lan, X., Fei, X. (., Kostjasyn, S., Adhyaru, P., Giang, J., Leung, E. L. Y., Strike, K., Pearcy, J., Somani, A., Wright, C., Matthews, C., Lee, G. & Tang, X.
1/01/14 → 31/12/27