TY - JOUR
T1 - Effects of substitution, and adding of carbohydrate and fat to whey-protein on energy intake, appetite, gastric emptying, glucose, insulin, ghrelin, cck and glp-1 in healthy older men—a randomized controlled trial
AU - Giezenaar, Caroline
AU - Van Der Burgh, Yonta
AU - Lange, Kylie
AU - Hatzinikolas, Seva
AU - Hausken, Trygve
AU - Jones, Karen L.
AU - Horowitz, Michael
AU - Chapman, Ian
AU - Soenen, Stijn
PY - 2018/2/1
Y1 - 2018/2/1
N2 - Protein-rich supplements are used widely for the management of malnutrition in the elderly. We reported previously that the suppression of energy intake by whey protein is less in older than younger adults. The aim was to determine the effects of substitution, and adding of carbohydrate and fat to whey protein, on ad libitum energy intake from a buffet meal (180–210 min), gastric emptying (3D-ultrasonography), plasma gut hormone concentrations (0–180 min) and appetite (visual analogue scales), in healthy older men. In a randomized, double-blind order, 13 older men (75 ± 2 years) ingested drinks (~450 mL) containing: (i) 70 g whey protein (280 kcal; ‘P280 ’); (ii) 14 g protein, 28 g carbohydrate, 12.4 g fat (280 kcal; ‘M280 ’); (iii) 70 g protein, 28 g carbohydrate, 12.4 g fat (504 kcal; ‘M504 ’); or (iv) control (~2 kcal). The caloric drinks, compared to a control, did not suppress appetite or energy intake; there was an increase in total energy intake (drink + meal, p < 0.05), which was increased most by the M504 -drink. P280 - and M504 -drink ingestion were associated with slower a gastric-emptying time (n = 9), lower ghrelin, and higher cholecystokinin (CCK) and glucagon-like peptide-1 (GLP-1) than M280 (p < 0.05). Glucose and insulin were increased most by the mixed-macronutrient drinks (p < 0.05). In conclusion, energy intake was not suppressed, compared to a control, and particularly whey protein, affected gastric emptying and gut hormone responses.
AB - Protein-rich supplements are used widely for the management of malnutrition in the elderly. We reported previously that the suppression of energy intake by whey protein is less in older than younger adults. The aim was to determine the effects of substitution, and adding of carbohydrate and fat to whey protein, on ad libitum energy intake from a buffet meal (180–210 min), gastric emptying (3D-ultrasonography), plasma gut hormone concentrations (0–180 min) and appetite (visual analogue scales), in healthy older men. In a randomized, double-blind order, 13 older men (75 ± 2 years) ingested drinks (~450 mL) containing: (i) 70 g whey protein (280 kcal; ‘P280 ’); (ii) 14 g protein, 28 g carbohydrate, 12.4 g fat (280 kcal; ‘M280 ’); (iii) 70 g protein, 28 g carbohydrate, 12.4 g fat (504 kcal; ‘M504 ’); or (iv) control (~2 kcal). The caloric drinks, compared to a control, did not suppress appetite or energy intake; there was an increase in total energy intake (drink + meal, p < 0.05), which was increased most by the M504 -drink. P280 - and M504 -drink ingestion were associated with slower a gastric-emptying time (n = 9), lower ghrelin, and higher cholecystokinin (CCK) and glucagon-like peptide-1 (GLP-1) than M280 (p < 0.05). Glucose and insulin were increased most by the mixed-macronutrient drinks (p < 0.05). In conclusion, energy intake was not suppressed, compared to a control, and particularly whey protein, affected gastric emptying and gut hormone responses.
UR - http://www.scopus.com/inward/record.url?scp=85041031254&partnerID=8YFLogxK
U2 - 10.3390/nu10020113
DO - 10.3390/nu10020113
M3 - Article
C2 - 29360778
AN - SCOPUS:85041031254
SN - 2072-6643
VL - 10
JO - Nutrients
JF - Nutrients
IS - 2
M1 - 113
ER -