Effects of substitution, and adding of carbohydrate and fat to whey-protein on energy intake, appetite, gastric emptying, glucose, insulin, ghrelin, cck and glp-1 in healthy older men—a randomized controlled trial

Caroline Giezenaar, Yonta Van Der Burgh, Kylie Lange, Seva Hatzinikolas, Trygve Hausken, Karen L. Jones, Michael Horowitz, Ian Chapman, Stijn Soenen

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Abstract

Protein-rich supplements are used widely for the management of malnutrition in the elderly. We reported previously that the suppression of energy intake by whey protein is less in older than younger adults. The aim was to determine the effects of substitution, and adding of carbohydrate and fat to whey protein, on ad libitum energy intake from a buffet meal (180–210 min), gastric emptying (3D-ultrasonography), plasma gut hormone concentrations (0–180 min) and appetite (visual analogue scales), in healthy older men. In a randomized, double-blind order, 13 older men (75 ± 2 years) ingested drinks (~450 mL) containing: (i) 70 g whey protein (280 kcal; ‘P280 ’); (ii) 14 g protein, 28 g carbohydrate, 12.4 g fat (280 kcal; ‘M280 ’); (iii) 70 g protein, 28 g carbohydrate, 12.4 g fat (504 kcal; ‘M504 ’); or (iv) control (~2 kcal). The caloric drinks, compared to a control, did not suppress appetite or energy intake; there was an increase in total energy intake (drink + meal, p < 0.05), which was increased most by the M504 -drink. P280 - and M504 -drink ingestion were associated with slower a gastric-emptying time (n = 9), lower ghrelin, and higher cholecystokinin (CCK) and glucagon-like peptide-1 (GLP-1) than M280 (p < 0.05). Glucose and insulin were increased most by the mixed-macronutrient drinks (p < 0.05). In conclusion, energy intake was not suppressed, compared to a control, and particularly whey protein, affected gastric emptying and gut hormone responses.

Original languageEnglish
Article number113
JournalNutrients
Volume10
Issue number2
DOIs
Publication statusPublished - 1 Feb 2018
Externally publishedYes

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ghrelin
gastric emptying
Ghrelin
Gastric Emptying
Appetite
appetite
Energy Intake
whey protein
energy intake
insulin
Randomized Controlled Trials
Fats
Carbohydrates
Insulin
carbohydrates
Glucose
glucose
lipids
Meals
Energy Drinks

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Giezenaar, Caroline ; Van Der Burgh, Yonta ; Lange, Kylie ; Hatzinikolas, Seva ; Hausken, Trygve ; Jones, Karen L. ; Horowitz, Michael ; Chapman, Ian ; Soenen, Stijn. / Effects of substitution, and adding of carbohydrate and fat to whey-protein on energy intake, appetite, gastric emptying, glucose, insulin, ghrelin, cck and glp-1 in healthy older men—a randomized controlled trial. In: Nutrients. 2018 ; Vol. 10, No. 2.
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abstract = "Protein-rich supplements are used widely for the management of malnutrition in the elderly. We reported previously that the suppression of energy intake by whey protein is less in older than younger adults. The aim was to determine the effects of substitution, and adding of carbohydrate and fat to whey protein, on ad libitum energy intake from a buffet meal (180–210 min), gastric emptying (3D-ultrasonography), plasma gut hormone concentrations (0–180 min) and appetite (visual analogue scales), in healthy older men. In a randomized, double-blind order, 13 older men (75 ± 2 years) ingested drinks (~450 mL) containing: (i) 70 g whey protein (280 kcal; ‘P280 ’); (ii) 14 g protein, 28 g carbohydrate, 12.4 g fat (280 kcal; ‘M280 ’); (iii) 70 g protein, 28 g carbohydrate, 12.4 g fat (504 kcal; ‘M504 ’); or (iv) control (~2 kcal). The caloric drinks, compared to a control, did not suppress appetite or energy intake; there was an increase in total energy intake (drink + meal, p < 0.05), which was increased most by the M504 -drink. P280 - and M504 -drink ingestion were associated with slower a gastric-emptying time (n = 9), lower ghrelin, and higher cholecystokinin (CCK) and glucagon-like peptide-1 (GLP-1) than M280 (p < 0.05). Glucose and insulin were increased most by the mixed-macronutrient drinks (p < 0.05). In conclusion, energy intake was not suppressed, compared to a control, and particularly whey protein, affected gastric emptying and gut hormone responses.",
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Effects of substitution, and adding of carbohydrate and fat to whey-protein on energy intake, appetite, gastric emptying, glucose, insulin, ghrelin, cck and glp-1 in healthy older men—a randomized controlled trial. / Giezenaar, Caroline; Van Der Burgh, Yonta; Lange, Kylie; Hatzinikolas, Seva; Hausken, Trygve; Jones, Karen L.; Horowitz, Michael; Chapman, Ian; Soenen, Stijn.

In: Nutrients, Vol. 10, No. 2, 113, 01.02.2018.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Chapman, Ian

AU - Soenen, Stijn

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