Effects of medroxyprogesterone acetate (Mpa) on myometrial activity in unmated rats: A study in vivo using video-laparoscopy

Linda H. Crane, Len Martin*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Abstract

Unmated female rats received medroxyprogesterone acetate (MPA) on the day of oestrus. Myometrial activity in vivo was quantified by video-laparoscopy 24-96 h later. Changes induced by MPA resembled those in early pregnancy/pseudopregnancy, but were not as extreme. There was a significant increase in circular contractions, followed by a decline, as in mated rats. Increases in circular contractions propagating caudally were as large as in mated rats, but increases in those propagating cranially were much smaller and qualitatively different. MPA induced only small increases in the frequency of longitudinal contractions propagating cranially, whereas large increases occurred in pregnancy/pseudo- pregnancy. We conclude that in early pregnancy/pseudopregnancy, increased circular activity is induced by rising progesterone levels. However, progesterone alone does not account for the increased contractions propagating cranially in mated rats. We suggest that these are induced by increased pacemaker activity in the region of the cervix, possibly activated by stimuli received during copulation.

Original languageEnglish
Pages (from-to)737-742
Number of pages6
JournalReproduction, Fertility and Development
Volume3
Issue number6
DOIs
Publication statusPublished - 1 Jan 1991
Externally publishedYes

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