Effects of Conception Using Assisted Reproductive Technologies on Infant Health and Development: An Evolutionary Perspective and Analysis Using UK Millennium Cohort Data

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)
8 Downloads (Pure)

Abstract

Millions of infants around the world have been born as a result of assisted reproductive technologies (ART), and in the past three decades ART has become increasingly effective and technologically sophisticated. At the same time, advances have been made in understanding the evolutionary biology of mate choice and post-copulatory processes. These advances have relevance for ART as ART methods to a greater or lesser extent circumvent potentially important natural processes determining which fertilized embryo is successfully implanted. Here, using UK Millennium cohort data, the hypothesis that ART methods which circumvent both natural in vivo selection of ova and sperm (for example in vitro fertilization) lead to poorer child health and developmental outcomes than ART methods in which fertilization occurs naturally after fertility treatment using drugs or diathermy. The results showed that both groups of ART were associated with the number of infant health problems from birth through the first week of life when compared with naturally conceived infants. Methods with artificial fertilization were associated with two of the four most common health conditions: respiratory distress (OR 1.80; 95% CI 1.12-2.91) and infections (OR 1.77; 95% CI 1.96-2.06). ART methods with artificial fertilization were associated with delayed achievement of developmental milestones at nine months, and when contrasted with ART using fertility drugs or diathermy only, were significantly more likely to be associated with slower child development. This suggests that evolved processes that determine which egg and sperm lead to successful pregnancy may be important for offspring quality as indicated by infant development. Clinically, the results suggest that women should avoid ART with artificial gamete selection if they can conceive using other ART methods.

Original languageEnglish
Pages (from-to)225-235
Number of pages11
JournalYale Journal of Biology and Medicine
Volume91
Issue number3
Publication statusPublished - Sep 2018

Fingerprint

Assisted Reproductive Techniques
Child Development
Health
Hyperthermia therapy
Fertilization
Diathermy
Ovum
Spermatozoa
Infant Health
Fertility Agents
Drug therapy
Birth Order
Fertilization in Vitro
Medical problems
Germ Cells
Fertility
Embryonic Structures

Cite this

@article{30c5ce09320c49faa9f451208096a516,
title = "Effects of Conception Using Assisted Reproductive Technologies on Infant Health and Development: An Evolutionary Perspective and Analysis Using UK Millennium Cohort Data",
abstract = "Millions of infants around the world have been born as a result of assisted reproductive technologies (ART), and in the past three decades ART has become increasingly effective and technologically sophisticated. At the same time, advances have been made in understanding the evolutionary biology of mate choice and post-copulatory processes. These advances have relevance for ART as ART methods to a greater or lesser extent circumvent potentially important natural processes determining which fertilized embryo is successfully implanted. Here, using UK Millennium cohort data, the hypothesis that ART methods which circumvent both natural in vivo selection of ova and sperm (for example in vitro fertilization) lead to poorer child health and developmental outcomes than ART methods in which fertilization occurs naturally after fertility treatment using drugs or diathermy. The results showed that both groups of ART were associated with the number of infant health problems from birth through the first week of life when compared with naturally conceived infants. Methods with artificial fertilization were associated with two of the four most common health conditions: respiratory distress (OR 1.80; 95{\%} CI 1.12-2.91) and infections (OR 1.77; 95{\%} CI 1.96-2.06). ART methods with artificial fertilization were associated with delayed achievement of developmental milestones at nine months, and when contrasted with ART using fertility drugs or diathermy only, were significantly more likely to be associated with slower child development. This suggests that evolved processes that determine which egg and sperm lead to successful pregnancy may be important for offspring quality as indicated by infant development. Clinically, the results suggest that women should avoid ART with artificial gamete selection if they can conceive using other ART methods.",
author = "David Waynforth",
year = "2018",
month = "9",
language = "English",
volume = "91",
pages = "225--235",
journal = "Yale Journal of Biology and Medicine",
issn = "0044-0086",
publisher = "Yale Journal of Biology and Medicine Inc.",
number = "3",

}

TY - JOUR

T1 - Effects of Conception Using Assisted Reproductive Technologies on Infant Health and Development

T2 - An Evolutionary Perspective and Analysis Using UK Millennium Cohort Data

AU - Waynforth, David

PY - 2018/9

Y1 - 2018/9

N2 - Millions of infants around the world have been born as a result of assisted reproductive technologies (ART), and in the past three decades ART has become increasingly effective and technologically sophisticated. At the same time, advances have been made in understanding the evolutionary biology of mate choice and post-copulatory processes. These advances have relevance for ART as ART methods to a greater or lesser extent circumvent potentially important natural processes determining which fertilized embryo is successfully implanted. Here, using UK Millennium cohort data, the hypothesis that ART methods which circumvent both natural in vivo selection of ova and sperm (for example in vitro fertilization) lead to poorer child health and developmental outcomes than ART methods in which fertilization occurs naturally after fertility treatment using drugs or diathermy. The results showed that both groups of ART were associated with the number of infant health problems from birth through the first week of life when compared with naturally conceived infants. Methods with artificial fertilization were associated with two of the four most common health conditions: respiratory distress (OR 1.80; 95% CI 1.12-2.91) and infections (OR 1.77; 95% CI 1.96-2.06). ART methods with artificial fertilization were associated with delayed achievement of developmental milestones at nine months, and when contrasted with ART using fertility drugs or diathermy only, were significantly more likely to be associated with slower child development. This suggests that evolved processes that determine which egg and sperm lead to successful pregnancy may be important for offspring quality as indicated by infant development. Clinically, the results suggest that women should avoid ART with artificial gamete selection if they can conceive using other ART methods.

AB - Millions of infants around the world have been born as a result of assisted reproductive technologies (ART), and in the past three decades ART has become increasingly effective and technologically sophisticated. At the same time, advances have been made in understanding the evolutionary biology of mate choice and post-copulatory processes. These advances have relevance for ART as ART methods to a greater or lesser extent circumvent potentially important natural processes determining which fertilized embryo is successfully implanted. Here, using UK Millennium cohort data, the hypothesis that ART methods which circumvent both natural in vivo selection of ova and sperm (for example in vitro fertilization) lead to poorer child health and developmental outcomes than ART methods in which fertilization occurs naturally after fertility treatment using drugs or diathermy. The results showed that both groups of ART were associated with the number of infant health problems from birth through the first week of life when compared with naturally conceived infants. Methods with artificial fertilization were associated with two of the four most common health conditions: respiratory distress (OR 1.80; 95% CI 1.12-2.91) and infections (OR 1.77; 95% CI 1.96-2.06). ART methods with artificial fertilization were associated with delayed achievement of developmental milestones at nine months, and when contrasted with ART using fertility drugs or diathermy only, were significantly more likely to be associated with slower child development. This suggests that evolved processes that determine which egg and sperm lead to successful pregnancy may be important for offspring quality as indicated by infant development. Clinically, the results suggest that women should avoid ART with artificial gamete selection if they can conceive using other ART methods.

UR - https://medicine.yale.edu/yjbm/openaccess/YJBM-Open_Access_License_9208_284_1519_v2.pdf

UR - http://www.scopus.com/inward/record.url?scp=85054101270&partnerID=8YFLogxK

M3 - Article

VL - 91

SP - 225

EP - 235

JO - Yale Journal of Biology and Medicine

JF - Yale Journal of Biology and Medicine

SN - 0044-0086

IS - 3

ER -