TY - JOUR
T1 - Effects of co-ingesting glucose and whey protein on blood glucose, plasma insulin and glucagon concentrations, and gastric emptying, in older men with and without type 2 diabetes
AU - Oberoi, Avneet
AU - Giezenaar, Caroline
AU - Rigda, Rachael S
AU - Horowitz, Michael
AU - Jones, Karen L
AU - Chapman, Ian
AU - Soenen, Stijn
N1 - This article is protected by copyright. All rights reserved.
Funding Information:
We thank Kylie Lange for statistical support, and Judith Wishart and Scott Standfield for technical assistance in the performance of biochemical assays. The CRE in Translating Nutritional Science to Good Health is supported by The Hospital Research Foundation. The research was funded by a Diabetes Australia Research Trust Grant (#Y19G‐SOES). SS was supported by a Royal Adelaide Hospital Florey Fellowship (#2129) and KLJ by a University of Adelaide William T. Southcott Research Fellowship. AO was supported by Adelaide Scholarship International. Open access publishing facilitated by The University of Adelaide, as part of the Wiley ‐ The University of Adelaide agreement via the Council of Australian University Librarians.
Publisher Copyright:
© 2023 The Authors. Diabetes, Obesity and Metabolism published by John Wiley & Sons Ltd.
PY - 2023/1/24
Y1 - 2023/1/24
N2 - Aim: To investigate whether co-ingestion of dietary protein with, or before, carbohydrate may be a useful strategy to reduce postprandial hyperglycaemia in older men with type 2 diabetes (T2D). Materials and Methods: Blood glucose, plasma insulin and glucagon concentrations were measured for 180 minutes following ingestion of a drink containing 30 g of glucose (G; 120 kcal), 30 g of whey protein (120 kcal), 30 g of glucose plus 30 g of whey protein (GP; 240 kcal), or control (~2 kcal) in older men with T2D (n = 10, 77 ± 1 years; 31 ± 1.7 kg/m 2) and without T2D (n = 10, 78 ± 2 years; 27 ± 1.4 kg/m 2). Mixed model analysis was used. Results: GP versus G markedly reduced the increase in blood glucose concentrations (P <.001) and had a synergistic effect on the increase in insulin concentrations (P <.001), in men both with and without T2D. Glucose concentrations were higher in men with T2D compared with those without T2D, whereas insulin and glucagon concentrations were largely unaffected by the presence of T2D. Gastric emptying was faster in men with T2D than in those without T2D. Conclusions: The ability of whey protein to reduce carbohydrate-induced, postprandial hyperglycaemia is retained in older men with T2D compared with those without T2D, and whey protein supplementation may be a useful strategy in the prevention and management of T2D in older people.
AB - Aim: To investigate whether co-ingestion of dietary protein with, or before, carbohydrate may be a useful strategy to reduce postprandial hyperglycaemia in older men with type 2 diabetes (T2D). Materials and Methods: Blood glucose, plasma insulin and glucagon concentrations were measured for 180 minutes following ingestion of a drink containing 30 g of glucose (G; 120 kcal), 30 g of whey protein (120 kcal), 30 g of glucose plus 30 g of whey protein (GP; 240 kcal), or control (~2 kcal) in older men with T2D (n = 10, 77 ± 1 years; 31 ± 1.7 kg/m 2) and without T2D (n = 10, 78 ± 2 years; 27 ± 1.4 kg/m 2). Mixed model analysis was used. Results: GP versus G markedly reduced the increase in blood glucose concentrations (P <.001) and had a synergistic effect on the increase in insulin concentrations (P <.001), in men both with and without T2D. Glucose concentrations were higher in men with T2D compared with those without T2D, whereas insulin and glucagon concentrations were largely unaffected by the presence of T2D. Gastric emptying was faster in men with T2D than in those without T2D. Conclusions: The ability of whey protein to reduce carbohydrate-induced, postprandial hyperglycaemia is retained in older men with T2D compared with those without T2D, and whey protein supplementation may be a useful strategy in the prevention and management of T2D in older people.
UR - http://www.scopus.com/inward/record.url?scp=85149343641&partnerID=8YFLogxK
U2 - 10.1111/dom.14983
DO - 10.1111/dom.14983
M3 - Article
C2 - 36694303
SN - 1462-8902
JO - Diabetes, Obesity and Metabolism
JF - Diabetes, Obesity and Metabolism
ER -
