Effects of anti-class I antibodies on proliferation of murine T lymphocytes

Antibodies specific for the murine Class I H-2K/D molecules have been analyzed for their effect on the proliferation of murine T cells. Several antibodies specific for both private and public determinants have been found to inhibit lectin-mediated T-cell proliferation. These same antibodies do not noticeably effect growth factor-dependent proliferation of activated T cells and have been found to stimulate rather than inhibit alloantigen-induced proliferation of T cells. Taken together these results suggest that Class I molecules may have some functional role in the early events of T-cell stimulation/proliferation, although the mechanisms for antibody effect may be different for T cells stimulated in different ways.