Effects of anti-class I antibodies on proliferation of murine T lymphocytes

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Abstract

Antibodies specific for the murine Class I H-2K/D molecules have been analyzed for their effect on the proliferation of murine T cells. Several antibodies specific for both private and public determinants have been found to inhibit lectin-mediated T-cell proliferation. These same antibodies do not noticeably effect growth factor-dependent proliferation of activated T cells and have been found to stimulate rather than inhibit alloantigen-induced proliferation of T cells. Taken together these results suggest that Class I molecules may have some functional role in the early events of T-cell stimulation/proliferation, although the mechanisms for antibody effect may be different for T cells stimulated in different ways.

Original languageEnglish
Pages (from-to)236-243
Number of pages8
JournalCellular Immunology
Volume112
Issue number1
DOIs
Publication statusPublished - Mar 1988
Externally publishedYes

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Immunoglobulin Isotypes
T-Lymphocytes
Antibodies
Cell Proliferation
Isoantigens
Lectins
Intercellular Signaling Peptides and Proteins

Cite this

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title = "Effects of anti-class I antibodies on proliferation of murine T lymphocytes",
abstract = "Antibodies specific for the murine Class I H-2K/D molecules have been analyzed for their effect on the proliferation of murine T cells. Several antibodies specific for both private and public determinants have been found to inhibit lectin-mediated T-cell proliferation. These same antibodies do not noticeably effect growth factor-dependent proliferation of activated T cells and have been found to stimulate rather than inhibit alloantigen-induced proliferation of T cells. Taken together these results suggest that Class I molecules may have some functional role in the early events of T-cell stimulation/proliferation, although the mechanisms for antibody effect may be different for T cells stimulated in different ways.",
author = "O'Neill, {H C}",
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Effects of anti-class I antibodies on proliferation of murine T lymphocytes. / O'Neill, H C.

In: Cellular Immunology, Vol. 112, No. 1, 03.1988, p. 236-243.

Research output: Contribution to journalArticleResearchpeer-review

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AB - Antibodies specific for the murine Class I H-2K/D molecules have been analyzed for their effect on the proliferation of murine T cells. Several antibodies specific for both private and public determinants have been found to inhibit lectin-mediated T-cell proliferation. These same antibodies do not noticeably effect growth factor-dependent proliferation of activated T cells and have been found to stimulate rather than inhibit alloantigen-induced proliferation of T cells. Taken together these results suggest that Class I molecules may have some functional role in the early events of T-cell stimulation/proliferation, although the mechanisms for antibody effect may be different for T cells stimulated in different ways.

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