Effect of selective excitatory amino acid antagonists on excitotoxin-induced changes in APP mRNA expression

David M. Pache; Rachel Hutchings; Robert D.E. Sewell; George A. Foster; Paul S.J. Spencer

Effect of selective excitatory amino acid antagonists on excitotoxin-induced changes in APP mRNA expression

David M. Pache^*, Rachel Hutchings, Robert D.E. Sewell, George A. Foster, Paul S.J. Spencer

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

Abstract

In situ hybridisation was used to determine whether the expression of two different isoforms of amyloid precursor protein (APP) mRNA (APP714 and APP751) could be selectively modified following treatment with excitatory amino acid agonists (quisqualic acid or ibotenic acid) when administered directly into the rat hippocampus either alone or following pre-treatment with a specific excitatory amino acid antagonist (2,3-dihydro-6-nitro-7-sulphamoyl-benzo(F)quinoxaline, NBQX; D-2-amino-5-phosphonovaleric acid, AP5; or 5,7-dichlorokynurenic acid, 5,7-DCKA). It was found that APP mRNA isoform expression was differentially influenced according to treatment. Central administration of an excitatory amino acid agonist may therefore be useful for investigating mechanisms controlling APP expression in vivo.

Original language	English
Pages (from-to)	205-212
Number of pages	8
Journal	Pharmacology Reviews and Communications
Volume	10
Issue number	3
Publication status	Published - 1 Jan 1999
Externally published	Yes

Cite this

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title = "Effect of selective excitatory amino acid antagonists on excitotoxin-induced changes in APP mRNA expression",

abstract = "In situ hybridisation was used to determine whether the expression of two different isoforms of amyloid precursor protein (APP) mRNA (APP714 and APP751) could be selectively modified following treatment with excitatory amino acid agonists (quisqualic acid or ibotenic acid) when administered directly into the rat hippocampus either alone or following pre-treatment with a specific excitatory amino acid antagonist (2,3-dihydro-6-nitro-7-sulphamoyl-benzo(F)quinoxaline, NBQX; D-2-amino-5-phosphonovaleric acid, AP5; or 5,7-dichlorokynurenic acid, 5,7-DCKA). It was found that APP mRNA isoform expression was differentially influenced according to treatment. Central administration of an excitatory amino acid agonist may therefore be useful for investigating mechanisms controlling APP expression in vivo.",

author = "Pache, {David M.} and Rachel Hutchings and Sewell, {Robert D.E.} and Foster, {George A.} and Spencer, {Paul S.J.}",

year = "1999",

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language = "English",

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journal = "Pharmacology Reviews and Communications",

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T1 - Effect of selective excitatory amino acid antagonists on excitotoxin-induced changes in APP mRNA expression

AU - Pache, David M.

AU - Hutchings, Rachel

AU - Sewell, Robert D.E.

AU - Foster, George A.

AU - Spencer, Paul S.J.

PY - 1999/1/1

Y1 - 1999/1/1

N2 - In situ hybridisation was used to determine whether the expression of two different isoforms of amyloid precursor protein (APP) mRNA (APP714 and APP751) could be selectively modified following treatment with excitatory amino acid agonists (quisqualic acid or ibotenic acid) when administered directly into the rat hippocampus either alone or following pre-treatment with a specific excitatory amino acid antagonist (2,3-dihydro-6-nitro-7-sulphamoyl-benzo(F)quinoxaline, NBQX; D-2-amino-5-phosphonovaleric acid, AP5; or 5,7-dichlorokynurenic acid, 5,7-DCKA). It was found that APP mRNA isoform expression was differentially influenced according to treatment. Central administration of an excitatory amino acid agonist may therefore be useful for investigating mechanisms controlling APP expression in vivo.

AB - In situ hybridisation was used to determine whether the expression of two different isoforms of amyloid precursor protein (APP) mRNA (APP714 and APP751) could be selectively modified following treatment with excitatory amino acid agonists (quisqualic acid or ibotenic acid) when administered directly into the rat hippocampus either alone or following pre-treatment with a specific excitatory amino acid antagonist (2,3-dihydro-6-nitro-7-sulphamoyl-benzo(F)quinoxaline, NBQX; D-2-amino-5-phosphonovaleric acid, AP5; or 5,7-dichlorokynurenic acid, 5,7-DCKA). It was found that APP mRNA isoform expression was differentially influenced according to treatment. Central administration of an excitatory amino acid agonist may therefore be useful for investigating mechanisms controlling APP expression in vivo.

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M3 - Article

AN - SCOPUS:0032802184

SN - 1028-8945

VL - 10

SP - 205

EP - 212

JO - Pharmacology Reviews and Communications

JF - Pharmacology Reviews and Communications

IS - 3

ER -

Effect of selective excitatory amino acid antagonists on excitotoxin-induced changes in APP mRNA expression

Abstract

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