Effect of selective excitatory amino acid antagonists on excitotoxin-induced changes in APP mRNA expression

David M. Pache*, Rachel Hutchings, Robert D.E. Sewell, George A. Foster, Paul S.J. Spencer

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

Abstract

In situ hybridisation was used to determine whether the expression of two different isoforms of amyloid precursor protein (APP) mRNA (APP714 and APP751) could be selectively modified following treatment with excitatory amino acid agonists (quisqualic acid or ibotenic acid) when administered directly into the rat hippocampus either alone or following pre-treatment with a specific excitatory amino acid antagonist (2,3-dihydro-6-nitro-7-sulphamoyl-benzo(F)quinoxaline, NBQX; D-2-amino-5-phosphonovaleric acid, AP5; or 5,7-dichlorokynurenic acid, 5,7-DCKA). It was found that APP mRNA isoform expression was differentially influenced according to treatment. Central administration of an excitatory amino acid agonist may therefore be useful for investigating mechanisms controlling APP expression in vivo.

Original languageEnglish
Pages (from-to)205-212
Number of pages8
JournalPharmacology Reviews and Communications
Volume10
Issue number3
Publication statusPublished - 1 Jan 1999
Externally publishedYes

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    Pache, D. M., Hutchings, R., Sewell, R. D. E., Foster, G. A., & Spencer, P. S. J. (1999). Effect of selective excitatory amino acid antagonists on excitotoxin-induced changes in APP mRNA expression. Pharmacology Reviews and Communications, 10(3), 205-212.