Effect of saffron supplementation on symptoms of depression and anxiety: a systematic review and meta-analysis

Wolfgang Marx, Melissa Lane, Tetyana Rocks, Anu Ruusunen, Amy Loughman, Adrian Lopresti, Skye Marshall, Michael Berk, Felice Jacka, Olivia May Dean

Research output: Contribution to journalArticleResearchpeer-review

Abstract

ContextSaffron (Crocus sativus L.) has gained interest as a potential treatment in psychiatry.ObjectiveThis systematic review and meta-analysis sought to investigate the effect of saffron supplementation, as both an adjunctive therapy and monotherapy, on symptoms of depression and anxiety in clinical and general populations compared with pharmacotherapy or placebo.Data sourcesUsing the PRISMA guidelines, a systematic literature review of randomized controlled trials was conducted.Data extractionA meta-analysis was conducted to determine treatment effect. Risk of bias was assessed using the Jadad scale.ResultsTwenty-three studies were included. Saffron had a large positive effect size when compared with placebo for depressive symptoms (g = 0.99, P < 0.001) and anxiety symptoms (g = 0.95, P < 0.006). Saffron also had a large positive effect size when used as an adjunct to antidepressants for depressive symptoms (g = 1.23, P = 0.028). Egger’s regression test found evidence of publication bias.ConclusionsSaffron could be an effective intervention for symptoms of depression and anxiety; however, due to evidence of publication bias and lack of regional diversity, further trials are required. PROSPERO registration CRD42017070060.
Original languageEnglish
Article numbernuz023
JournalNutrition Reviews
DOIs
Publication statusPublished - 28 May 2019

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Meta-Analysis
Anxiety
Depression
Publication Bias
Placebos
Antidepressive Agents
Psychiatry
Therapeutics
Randomized Controlled Trials
Guidelines
Drug Therapy
Population

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Marx, W., Lane, M., Rocks, T., Ruusunen, A., Loughman, A., Lopresti, A., ... Dean, O. M. (2019). Effect of saffron supplementation on symptoms of depression and anxiety: a systematic review and meta-analysis. Nutrition Reviews, [nuz023]. https://doi.org/10.1093/nutrit/nuz023
Marx, Wolfgang ; Lane, Melissa ; Rocks, Tetyana ; Ruusunen, Anu ; Loughman, Amy ; Lopresti, Adrian ; Marshall, Skye ; Berk, Michael ; Jacka, Felice ; Dean, Olivia May. / Effect of saffron supplementation on symptoms of depression and anxiety: a systematic review and meta-analysis. In: Nutrition Reviews. 2019.
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abstract = "ContextSaffron (Crocus sativus L.) has gained interest as a potential treatment in psychiatry.ObjectiveThis systematic review and meta-analysis sought to investigate the effect of saffron supplementation, as both an adjunctive therapy and monotherapy, on symptoms of depression and anxiety in clinical and general populations compared with pharmacotherapy or placebo.Data sourcesUsing the PRISMA guidelines, a systematic literature review of randomized controlled trials was conducted.Data extractionA meta-analysis was conducted to determine treatment effect. Risk of bias was assessed using the Jadad scale.ResultsTwenty-three studies were included. Saffron had a large positive effect size when compared with placebo for depressive symptoms (g = 0.99, P < 0.001) and anxiety symptoms (g = 0.95, P < 0.006). Saffron also had a large positive effect size when used as an adjunct to antidepressants for depressive symptoms (g = 1.23, P = 0.028). Egger’s regression test found evidence of publication bias.ConclusionsSaffron could be an effective intervention for symptoms of depression and anxiety; however, due to evidence of publication bias and lack of regional diversity, further trials are required. PROSPERO registration CRD42017070060.",
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Effect of saffron supplementation on symptoms of depression and anxiety: a systematic review and meta-analysis. / Marx, Wolfgang; Lane, Melissa; Rocks, Tetyana; Ruusunen, Anu; Loughman, Amy; Lopresti, Adrian; Marshall, Skye; Berk, Michael; Jacka, Felice; Dean, Olivia May.

In: Nutrition Reviews, 28.05.2019.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Lane, Melissa

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AU - Ruusunen, Anu

AU - Loughman, Amy

AU - Lopresti, Adrian

AU - Marshall, Skye

AU - Berk, Michael

AU - Jacka, Felice

AU - Dean, Olivia May

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N2 - ContextSaffron (Crocus sativus L.) has gained interest as a potential treatment in psychiatry.ObjectiveThis systematic review and meta-analysis sought to investigate the effect of saffron supplementation, as both an adjunctive therapy and monotherapy, on symptoms of depression and anxiety in clinical and general populations compared with pharmacotherapy or placebo.Data sourcesUsing the PRISMA guidelines, a systematic literature review of randomized controlled trials was conducted.Data extractionA meta-analysis was conducted to determine treatment effect. Risk of bias was assessed using the Jadad scale.ResultsTwenty-three studies were included. Saffron had a large positive effect size when compared with placebo for depressive symptoms (g = 0.99, P < 0.001) and anxiety symptoms (g = 0.95, P < 0.006). Saffron also had a large positive effect size when used as an adjunct to antidepressants for depressive symptoms (g = 1.23, P = 0.028). Egger’s regression test found evidence of publication bias.ConclusionsSaffron could be an effective intervention for symptoms of depression and anxiety; however, due to evidence of publication bias and lack of regional diversity, further trials are required. PROSPERO registration CRD42017070060.

AB - ContextSaffron (Crocus sativus L.) has gained interest as a potential treatment in psychiatry.ObjectiveThis systematic review and meta-analysis sought to investigate the effect of saffron supplementation, as both an adjunctive therapy and monotherapy, on symptoms of depression and anxiety in clinical and general populations compared with pharmacotherapy or placebo.Data sourcesUsing the PRISMA guidelines, a systematic literature review of randomized controlled trials was conducted.Data extractionA meta-analysis was conducted to determine treatment effect. Risk of bias was assessed using the Jadad scale.ResultsTwenty-three studies were included. Saffron had a large positive effect size when compared with placebo for depressive symptoms (g = 0.99, P < 0.001) and anxiety symptoms (g = 0.95, P < 0.006). Saffron also had a large positive effect size when used as an adjunct to antidepressants for depressive symptoms (g = 1.23, P = 0.028). Egger’s regression test found evidence of publication bias.ConclusionsSaffron could be an effective intervention for symptoms of depression and anxiety; however, due to evidence of publication bias and lack of regional diversity, further trials are required. PROSPERO registration CRD42017070060.

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