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Background: Previous clinical studies have suggested that high polyphenol extra virgin olive oil (EVOO) provides a superior cardioprotective effect compared to low polyphenol olive oil. However, further studies are required to replicate these results in non-Mediterranean populations.
Aim: To investigate the effect of high polyphenol EVOO versus low polyphenol olive oil with known polyphenol composition on markers of cardiovascular disease risk in a healthy non-Mediterranean cohort.
Methods: In a double-blind randomised cross-over trial, the present study will examine the effect of high polyphenol EVOO versus low polyphenol olive oil in 50 healthy participants. Each intervention phase will be 3 weeks long with a 2-week washout period between each phase. Outcomes to be assessed include HDL cholesterol efflux, oxidised LDL, blood lipids, C-reactive protein, arterial stiffness, blood pressure and cognitive function. Dietary intake, physical activity levels and anthropometry will also be collected.
Discussion: Because of the rigorous trial design, novel and clinically relevant outcomes, the use of a well-characterised EVOO, and, in contrast to the current literature, the non-Mediterranean study population, the present study will provide a significant contribution to the understanding of the clinical importance of polyphenol intake in the Australian sociocultural context.
|Number of pages||6|
|Journal||Nutrition and Dietetics|
|Early online date||17 Apr 2019|
|Publication status||Published - 1 Nov 2020|
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Nutrition for Chronic Disease and Disability: Research to improve health related quality of life and bring forward the under-represented voice
Reidlinger, D., Davidson, A., Campbell, K., Kelly, J., Mayr, H., English, C., Odgers-Jewell, K., MacKenzie-Shalders, K., Van der Meij, B., Crichton, M., Marshall, S., Turner, C., Marx, W., Utter, J. & Tang, X.
1/01/14 → 31/08/30