TY - JOUR
T1 - Editorial: Establishing genetic pleiotropy to identify common pharmacological agents for common diseases
AU - O'Mara, Tracy A.
AU - Batra, Jyotsna
AU - Glubb, Dylan
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Pleiotropy, the phenomenon where one gene affects multiple traits, appears to be pervasive in biology. For example, findings from genome-wide association studies (GWAS) demonstrate that GWAS loci for different traits overlap nearly 50% of the time (Chesmore et al., 2018). Often these traits are related, as is illustrated by GWAS of endometrial cancer risk, where all 16 known loci contain variation that has been associated with other traits, including susceptibility to other cancer types as well as known risk factors for endometrial cancer (e.g., body mass index and age of menarche) (O’Mara et al., 2019).
AB - Pleiotropy, the phenomenon where one gene affects multiple traits, appears to be pervasive in biology. For example, findings from genome-wide association studies (GWAS) demonstrate that GWAS loci for different traits overlap nearly 50% of the time (Chesmore et al., 2018). Often these traits are related, as is illustrated by GWAS of endometrial cancer risk, where all 16 known loci contain variation that has been associated with other traits, including susceptibility to other cancer types as well as known risk factors for endometrial cancer (e.g., body mass index and age of menarche) (O’Mara et al., 2019).
UR - http://www.scopus.com/inward/record.url?scp=85072921437&partnerID=8YFLogxK
U2 - 10.3389/fphar.2019.01038
DO - 10.3389/fphar.2019.01038
M3 - Editorial
AN - SCOPUS:85072921437
SN - 1663-9812
VL - 10
SP - 1
EP - 2
JO - Frontiers in Pharmacology
JF - Frontiers in Pharmacology
M1 - 1038
ER -
