TY - JOUR
T1 - Does psychological resilience buffer against the link between the 5-HTTLPR polymorphism and depression following stress
AU - Sharpley, Christopher F.
AU - Christie, David R H
AU - Bitsika, Vicki
AU - Andronicos, Nicholas M.
AU - Agnew, Linda L.
AU - McMillan, Mary E
PY - 2017/10/15
Y1 - 2017/10/15
N2 - The comparative strength of the 5-HTTLPR polymorphism as a 'predictor' of depression after major stress, versus the 'protective' effect of psychological resilience (PR) against depression after major stress, was tested in a homogeneous sample of older men who had all received a diagnosis and treatment for prostate cancer. Results supported the association between PR and lower depression after stress, but did not support the association between the 5-HTTLPR and elevated depression after stress. Examination of PR at scale, factor, and item level identified the specific PR-related behaviour that was the most powerful predictor of low depression. These data suggest that the carriage of the short form of the 5-HTTLPR may negate the protective effect of PR against depression in these men, or that PR may nullify the depression vulnerability of this form of the 5-HTTLPR. These findings may explain some of the 'null' findings regarding the link between the 5-HTTLPR and depression in the wider literature by arguing for an interaction between these two factors in the association between major stress and depression.
AB - The comparative strength of the 5-HTTLPR polymorphism as a 'predictor' of depression after major stress, versus the 'protective' effect of psychological resilience (PR) against depression after major stress, was tested in a homogeneous sample of older men who had all received a diagnosis and treatment for prostate cancer. Results supported the association between PR and lower depression after stress, but did not support the association between the 5-HTTLPR and elevated depression after stress. Examination of PR at scale, factor, and item level identified the specific PR-related behaviour that was the most powerful predictor of low depression. These data suggest that the carriage of the short form of the 5-HTTLPR may negate the protective effect of PR against depression in these men, or that PR may nullify the depression vulnerability of this form of the 5-HTTLPR. These findings may explain some of the 'null' findings regarding the link between the 5-HTTLPR and depression in the wider literature by arguing for an interaction between these two factors in the association between major stress and depression.
UR - http://www.scopus.com/inward/record.url?scp=85027506386&partnerID=8YFLogxK
U2 - 10.1016/j.physbeh.2017.07.029
DO - 10.1016/j.physbeh.2017.07.029
M3 - Article
AN - SCOPUS:85027506386
SN - 0031-9384
VL - 180
SP - 53
EP - 59
JO - Physiology and Behavior
JF - Physiology and Behavior
ER -