Does initial skeletal muscle size or sex affect the magnitude of muscle loss in response to 14 days immobilization?

Vernon G Coffey, Chris McGlory, Stuart M Phillips, Thomas M Doering

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Abstract

We aimed to determine whether there was a relationship between pre-immobilization skeletal muscle size and the magnitude of muscle atrophy following 14 days of unilateral lower limb immobilization. Our findings ( n = 30) show that pre-immobilization leg fat-free mass and quadriceps cross-sectional area (CSA) were unrelated to the magnitude of muscle atrophy. However, sex-based differences may be present, but confirmatory work is required. In women, pre-immobilization leg fat-free mass and CSA were associated with changes in quadriceps CSA after immobilization ( n = 9, r 2 = 0.54-0.68; P < 0.05). The extent of muscle atrophy is not affected by initial muscle mass, but there is potential for sex-based differences.

Original languageEnglish
Pages (from-to)411-416
Number of pages6
JournalApplied physiology, nutrition, and metabolism
Volume48
Issue number5
Early online date21 Feb 2023
DOIs
Publication statusPublished - 2023

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