@article{e7f30697d600438388512a4e066a77f2,
title = "Does initial skeletal muscle size or sex affect the magnitude of muscle loss in response to 14 days immobilization?",
abstract = "We aimed to determine whether there was a relationship between pre-immobilization skeletal muscle size and the magnitude of muscle atrophy following 14 days of unilateral lower limb immobilization. Our findings ( n = 30) show that pre-immobilization leg fat-free mass and quadriceps cross-sectional area (CSA) were unrelated to the magnitude of muscle atrophy. However, sex-based differences may be present, but confirmatory work is required. In women, pre-immobilization leg fat-free mass and CSA were associated with changes in quadriceps CSA after immobilization ( n = 9, r 2 = 0.54-0.68; P < 0.05). The extent of muscle atrophy is not affected by initial muscle mass, but there is potential for sex-based differences. ",
author = "Coffey, {Vernon G} and Chris McGlory and Phillips, {Stuart M} and Doering, {Thomas M}",
note = "Funding Information: SMP reports grants or research contracts from the US National Dairy Council, Canadian Institutes for Health Research, Dairy Farmers of Canada, Roquette Freres, Ontario Centre of Innovation, Nestle Health Sciences, Myos, National Science and Engineering Research Council, and the US NIH during the conduct of the study; personal fees from Nestle Health Sciences, non-financial support from Enhanced Recovery, outside the submitted work. SMP has patents licensed to Exerkine but reports no financial gains from any patent or related work. The other authors declare there are no competing interests. Funding Information: for this study was supported by the Collaborative Research Network for Advancing Exercise and Sport Science (CRN-AESS-201202) scheme awarded to VGC by the Department of Education and Training Australia and a Canadian Institutes of Health Research Award to SMP. CM acknowledges research fellowships from Diabetes Canada and the European Society for Clinical Nutrition and Metabolism. Funding Information: Funding for this study was supported by the Collaborative Research Network for Advancing Exercise and Sport Science (CRN-AESS-201202) scheme awarded to VGC by the Department of Education and Training Australia and a Canadian Institutes of Health Research Award to SMP. CM acknowledges research fellowships from Diabetes Canada and the European Society for Clinical Nutrition and Metabolism. Publisher Copyright: {\textcopyright} 2023 The Author(s).",
year = "2023",
doi = "10.1139/apnm-2022-0458",
language = "English",
volume = "48",
pages = "411--416",
journal = "Applied Physiology, Nutrition and Metabolism",
issn = "1715-5312",
publisher = "National Research Council of Canada",
number = "5",
}