The textile industry is a significant source of nonyphenol and their ethoxylates, which are suggested to be responsible for endocrine disruption in wildlife and humans. This study is a comparison of two conventional wastewater treatment processes in a cotton and a synthetic fiber factory in Vietnam, with regard to the distribution and removal of nonyphenol ethoxylates and nonyphenol throughout each process. Diverse trends in the distribution of nonyphenol ethoxylates in wastewater from factories, distinguished by their raw materials, could be revealed. Primary coagulation might not perfectly facilitate nitrification in the secondary activated sludge process regarding pH. Nevertheless, satisfactory removals were achieved during coagulation and activated sludge processes in both systems. The roles of long hydraulic retention times (21 and 16 h, respectively), low organic loadings (0.1 and 0.2 gCOD/gMLVSS.day, respectively), extended solids retention times (61 and 66 days, respectively), and mixed liquor suspended solids of greater than 2000 mg/L have been demonstrated. The findings provide evidence and a better understanding of nonyphenol ethoxylate and nonyphenol removal efficacy as well as influencing factors in Vietnamese textile wastewater treatment. The results are beneficial for the textile industry in Vietnam regarding investment decisions for wastewater treatment.