TY - JOUR
T1 - Differing models of association between childhood events, recent life stressors, psychological resilience and depression across three alleles of the serotonin transporter 5-HTTLPR
AU - Sharpley, Christopher F.
AU - Palanisamy, Suresh K A
AU - McFarlane, James R.
PY - 2013/8/15
Y1 - 2013/8/15
N2 - Background: Although some previous research has implicated the short form (ss) of the serotonin transporter 5- HTTLPR gene in the association between distal and proximal environmental stress and depression, over 38% of studies included in a recent meta-analysis failed to support that finding. Another variant of the 5-HTTLPT, the sl, has been relatively under-examined and may explain the inconsistency of the ss/ll dichotomy. In addition, a potential "buffer" variable between proximal and distal stress and depression - psychological resilience - may interact with the forms of the 5-HTTLPR This study investigated the ways the three forms of the 5-HTTLPR interacted with distal and proximal stress, and psychological resilience, to predict depression.Methods: A volunteer community sample of 65 female and 55 male volunteers completed background, childhood stress (Adverse Childhood Events-ACE), recent stress RLS), depression (Zung Self-Rating Depression Scale-ZSDS) and resilience (Connors-Davidson Resilience Scale-CD-RISC) questionnaires, plus gave a sample for genotyping to determine presence of ss, sl, or ll variants of the 5-HTTLPRResults: Comparison of the regression equations for each 5-HTTLPR variant showed that the combination of ACE, RLS and CD-RISC significantly predicted ZSDS scores for the sl variant; ACE, CD-RISC (but not RLS) significantly predicted ZSDS for the ll variant; and none of these significantly predicted ZSDS for the ss variant. Conclusions: Previous inconsistentfindings regarding the differences in the stress-depression interaction for the ss and ll may be explained by the more complex interaction effects of the sl variant with distal and recent stressors and psychological resilience.
AB - Background: Although some previous research has implicated the short form (ss) of the serotonin transporter 5- HTTLPR gene in the association between distal and proximal environmental stress and depression, over 38% of studies included in a recent meta-analysis failed to support that finding. Another variant of the 5-HTTLPT, the sl, has been relatively under-examined and may explain the inconsistency of the ss/ll dichotomy. In addition, a potential "buffer" variable between proximal and distal stress and depression - psychological resilience - may interact with the forms of the 5-HTTLPR This study investigated the ways the three forms of the 5-HTTLPR interacted with distal and proximal stress, and psychological resilience, to predict depression.Methods: A volunteer community sample of 65 female and 55 male volunteers completed background, childhood stress (Adverse Childhood Events-ACE), recent stress RLS), depression (Zung Self-Rating Depression Scale-ZSDS) and resilience (Connors-Davidson Resilience Scale-CD-RISC) questionnaires, plus gave a sample for genotyping to determine presence of ss, sl, or ll variants of the 5-HTTLPRResults: Comparison of the regression equations for each 5-HTTLPR variant showed that the combination of ACE, RLS and CD-RISC significantly predicted ZSDS scores for the sl variant; ACE, CD-RISC (but not RLS) significantly predicted ZSDS for the ll variant; and none of these significantly predicted ZSDS for the ss variant. Conclusions: Previous inconsistentfindings regarding the differences in the stress-depression interaction for the ss and ll may be explained by the more complex interaction effects of the sl variant with distal and recent stressors and psychological resilience.
UR - http://www.scopus.com/inward/record.url?scp=84881496205&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:84881496205
SN - 1433-1055
VL - 16
SP - 103
EP - 111
JO - German Journal of Psychiatry
JF - German Journal of Psychiatry
IS - 3
ER -