Differential regulation of cardiac α‐ and β‐adrenoceptors by the sympathetic nervous system

Russell Chess‐Williams, Bridget Doubleday, Gavin P. Reynolds

Research output: Contribution to journalArticleResearchpeer-review

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Abstract

1 The effects of depressed sympathetic function on the inotropic responses of the heart to sympathomimetic amines have been examined in rats immunized against nerve growth factor (NGF) 6 weeks prior to the isolation of cardiac tissues. 2 The activity of tyrosine hydroxylase in cervical sympathetic ganglia and the levels of noradrenaline in ventricular tissue were significantly reduced in NGF‐immunized rats. 3 Left atria and papillary muscles from NGF‐immunized rats were supersensitive to the β‐adrenoceptor agonist isoprenaline when compared with controls. 4 The responses of cardiac tissues to the α‐adrenoceptor agonist phenylephrine were unaffected by immunization. 5 These results support the hypothesis that cardiac β‐ but not α‐adrenoceptor sensitivity is regulated by the sympathetic nervous system.

Original languageEnglish
Pages (from-to)29-36
Number of pages8
JournalJournal of Autonomic Pharmacology
Volume14
Issue number1
DOIs
Publication statusPublished - 1 Jan 1994
Externally publishedYes

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Sympathetic Nervous System
Adrenergic Receptors
Sympathetic Ganglia
Sympathomimetics
Papillary Muscles
Tyrosine 3-Monooxygenase
Phenylephrine
Nerve Growth Factor
Heart Atria
Isoproterenol
Immunization
Norepinephrine

Cite this

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abstract = "1 The effects of depressed sympathetic function on the inotropic responses of the heart to sympathomimetic amines have been examined in rats immunized against nerve growth factor (NGF) 6 weeks prior to the isolation of cardiac tissues. 2 The activity of tyrosine hydroxylase in cervical sympathetic ganglia and the levels of noradrenaline in ventricular tissue were significantly reduced in NGF‐immunized rats. 3 Left atria and papillary muscles from NGF‐immunized rats were supersensitive to the β‐adrenoceptor agonist isoprenaline when compared with controls. 4 The responses of cardiac tissues to the α‐adrenoceptor agonist phenylephrine were unaffected by immunization. 5 These results support the hypothesis that cardiac β‐ but not α‐adrenoceptor sensitivity is regulated by the sympathetic nervous system.",
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Differential regulation of cardiac α‐ and β‐adrenoceptors by the sympathetic nervous system. / Chess‐Williams, Russell; Doubleday, Bridget; Reynolds, Gavin P.

In: Journal of Autonomic Pharmacology, Vol. 14, No. 1, 01.01.1994, p. 29-36.

Research output: Contribution to journalArticleResearchpeer-review

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