Dietary sodium modifies serum uric acid concentrations in humans

Alwyn S Todd, Robert J Walker, Robert J MacGinley, Jaimon Kelly, Tony R Merriman, Tanya J Major, Richard J Johnson

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Abstract

BACKGROUND: Subjects with hypertension are frequently obese or insulin resistant, both conditions in which hyperuricemia is common. Obese and insulin-resistant subjects are also known to have blood pressure that is more sensitive to changes in dietary sodium intake. Whether hyperuricemia is a resulting consequence, moderating or contributing factor to the development of hypertension has not been fully evaluated and very few studies have reported interactions between sodium intake and serum uric acid.

METHODS: We performed further analysis of our randomized controlled clinical trials (Australian New Zealand Clinical Trials Registry #12609000161224 and #12609000292279) designed to assess the effects of modifying sodium intake on concentrations of serum markers, including uric acid. Uric acid and other variables (including blood pressure, renin, and aldosterone) were measured at baseline and 4 weeks following the commencement of low (60 mmol/day), moderate (150 mmol/day), and high (200-250 mmol/day) dietary sodium intake.

RESULTS: The median aldosterone-to-renin ratio was 1.90 [pg/ml]/[pg/ml] (range 0.10-11.04). Serum uric acid fell significantly in both the moderate and high interventions compared to the low sodium intervention. This pattern of response occurred when all subjects were analyzed, and when normotensive or hypertensive subjects were analyzed alone.

CONCLUSIONS: Although previously reported in hypertensive subjects, these data provide evidence in normotensive subjects of an interaction between dietary sodium intake and serum uric acid. As this interaction is present in the absence of hypertension, it is possible it could play a role in hypertension development, and will need to be considered in future trials of dietary sodium intake.

CLINICAL TRIALS REGISTRATION: The trials were registered with the Australian and New Zealand Clinical Trials Registry as ACTRN12609000161224 and ACTRN1260.

Original languageEnglish
Pages (from-to)1196-1202
Number of pages7
JournalAmerican Journal of Hypertension
Volume30
Issue number12
DOIs
Publication statusPublished - 1 Dec 2017

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Dietary Sodium
Uric Acid
Hypertension
Serum
Hyperuricemia
Sodium
Clinical Trials
Aldosterone
New Zealand
Renin
Registries
Insulin
Blood Pressure
Randomized Controlled Trials
Biomarkers

Cite this

Todd, A. S., Walker, R. J., MacGinley, R. J., Kelly, J., Merriman, T. R., Major, T. J., & Johnson, R. J. (2017). Dietary sodium modifies serum uric acid concentrations in humans. American Journal of Hypertension, 30(12), 1196-1202. https://doi.org/10.1093/ajh/hpx123
Todd, Alwyn S ; Walker, Robert J ; MacGinley, Robert J ; Kelly, Jaimon ; Merriman, Tony R ; Major, Tanya J ; Johnson, Richard J. / Dietary sodium modifies serum uric acid concentrations in humans. In: American Journal of Hypertension. 2017 ; Vol. 30, No. 12. pp. 1196-1202.
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abstract = "BACKGROUND: Subjects with hypertension are frequently obese or insulin resistant, both conditions in which hyperuricemia is common. Obese and insulin-resistant subjects are also known to have blood pressure that is more sensitive to changes in dietary sodium intake. Whether hyperuricemia is a resulting consequence, moderating or contributing factor to the development of hypertension has not been fully evaluated and very few studies have reported interactions between sodium intake and serum uric acid.METHODS: We performed further analysis of our randomized controlled clinical trials (Australian New Zealand Clinical Trials Registry #12609000161224 and #12609000292279) designed to assess the effects of modifying sodium intake on concentrations of serum markers, including uric acid. Uric acid and other variables (including blood pressure, renin, and aldosterone) were measured at baseline and 4 weeks following the commencement of low (60 mmol/day), moderate (150 mmol/day), and high (200-250 mmol/day) dietary sodium intake.RESULTS: The median aldosterone-to-renin ratio was 1.90 [pg/ml]/[pg/ml] (range 0.10-11.04). Serum uric acid fell significantly in both the moderate and high interventions compared to the low sodium intervention. This pattern of response occurred when all subjects were analyzed, and when normotensive or hypertensive subjects were analyzed alone.CONCLUSIONS: Although previously reported in hypertensive subjects, these data provide evidence in normotensive subjects of an interaction between dietary sodium intake and serum uric acid. As this interaction is present in the absence of hypertension, it is possible it could play a role in hypertension development, and will need to be considered in future trials of dietary sodium intake.CLINICAL TRIALS REGISTRATION: The trials were registered with the Australian and New Zealand Clinical Trials Registry as ACTRN12609000161224 and ACTRN1260.",
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Todd, AS, Walker, RJ, MacGinley, RJ, Kelly, J, Merriman, TR, Major, TJ & Johnson, RJ 2017, 'Dietary sodium modifies serum uric acid concentrations in humans' American Journal of Hypertension, vol. 30, no. 12, pp. 1196-1202. https://doi.org/10.1093/ajh/hpx123

Dietary sodium modifies serum uric acid concentrations in humans. / Todd, Alwyn S; Walker, Robert J; MacGinley, Robert J; Kelly, Jaimon; Merriman, Tony R; Major, Tanya J; Johnson, Richard J.

In: American Journal of Hypertension, Vol. 30, No. 12, 01.12.2017, p. 1196-1202.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Dietary sodium modifies serum uric acid concentrations in humans

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AU - MacGinley, Robert J

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AU - Merriman, Tony R

AU - Major, Tanya J

AU - Johnson, Richard J

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N2 - BACKGROUND: Subjects with hypertension are frequently obese or insulin resistant, both conditions in which hyperuricemia is common. Obese and insulin-resistant subjects are also known to have blood pressure that is more sensitive to changes in dietary sodium intake. Whether hyperuricemia is a resulting consequence, moderating or contributing factor to the development of hypertension has not been fully evaluated and very few studies have reported interactions between sodium intake and serum uric acid.METHODS: We performed further analysis of our randomized controlled clinical trials (Australian New Zealand Clinical Trials Registry #12609000161224 and #12609000292279) designed to assess the effects of modifying sodium intake on concentrations of serum markers, including uric acid. Uric acid and other variables (including blood pressure, renin, and aldosterone) were measured at baseline and 4 weeks following the commencement of low (60 mmol/day), moderate (150 mmol/day), and high (200-250 mmol/day) dietary sodium intake.RESULTS: The median aldosterone-to-renin ratio was 1.90 [pg/ml]/[pg/ml] (range 0.10-11.04). Serum uric acid fell significantly in both the moderate and high interventions compared to the low sodium intervention. This pattern of response occurred when all subjects were analyzed, and when normotensive or hypertensive subjects were analyzed alone.CONCLUSIONS: Although previously reported in hypertensive subjects, these data provide evidence in normotensive subjects of an interaction between dietary sodium intake and serum uric acid. As this interaction is present in the absence of hypertension, it is possible it could play a role in hypertension development, and will need to be considered in future trials of dietary sodium intake.CLINICAL TRIALS REGISTRATION: The trials were registered with the Australian and New Zealand Clinical Trials Registry as ACTRN12609000161224 and ACTRN1260.

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Todd AS, Walker RJ, MacGinley RJ, Kelly J, Merriman TR, Major TJ et al. Dietary sodium modifies serum uric acid concentrations in humans. American Journal of Hypertension. 2017 Dec 1;30(12):1196-1202. https://doi.org/10.1093/ajh/hpx123