Dietary habits are related to outcomes in patients with advanced heart failure awaiting heart transplantation

Heike Spaderna, Daniela Zahn, Johanna Pretsch, Sonja L. Connor, Armin Zittermann, Stefanie Schulze Schleithoff, Katrina A. Bramstedt, Jacqueline M A Smits, Gerdi Weidner

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Abstract

Background: Empirical evidence supporting the benefits of dietary recommendations for patients with advanced heart failure is scarce. We prospectively evaluated the relation of dietary habits to pre-transplant clinical outcomes in the multisite observational Waiting for a New Heart Study. Methods and Results: A total of 318 heart transplant candidates (82% male, age 53 ± 11 years) completed a Food Frequency Questionnaire (foods high in salt, saturated fats, poly-/monounsaturated fats [PUFA+MUFA], fruit/vegetables/legumes, and fluid intake) at time of waitlisting. Cox proportional hazard models controlling for heart failure severity (eg, Heart Failure Survival Score, creatinine) estimated cause-specific hazard ratios (HRs) associated with each dietary habit individually, and with all dietary habits entered simultaneously. During follow-up (median 338 days, range 13-1,394), 54 patients died, 151 received transplants (110 in high-urgency status, 41 electively), and 45 became delisted (15 deteriorated, 30 improved). Two robust findings emerged: Frequent intake of salty foods, which correlated positively with saturated fat and fluid intake, was associated with transplantation in high-urgency status (HR 2.90, 95% confidence interval [CI] 1.55-5.42); and frequent intake of foods rich in PUFA+MUFA reduced the risk for death/deterioration (HR 0.49, 95% CI 0.26-0.92). Conclusions: These results support the importance of dietary habits for the prognosis of patients listed for heart transplantation, independently from heart failure severity.

Original languageEnglish
Pages (from-to)240-250
Number of pages11
JournalJournal of Cardiac Failure
Volume19
Issue number4
DOIs
Publication statusPublished - Apr 2013

Fingerprint

Feeding Behavior
Heart Transplantation
Heart Failure
Fats
Transplants
Eating
Confidence Intervals
Food
Proportional Hazards Models
Fabaceae
Vegetables
Fruit
Creatinine
Salts
Transplantation
Survival

Cite this

Spaderna, H., Zahn, D., Pretsch, J., Connor, S. L., Zittermann, A., Schulze Schleithoff, S., ... Weidner, G. (2013). Dietary habits are related to outcomes in patients with advanced heart failure awaiting heart transplantation. Journal of Cardiac Failure, 19(4), 240-250. https://doi.org/10.1016/j.cardfail.2013.02.004
Spaderna, Heike ; Zahn, Daniela ; Pretsch, Johanna ; Connor, Sonja L. ; Zittermann, Armin ; Schulze Schleithoff, Stefanie ; Bramstedt, Katrina A. ; Smits, Jacqueline M A ; Weidner, Gerdi. / Dietary habits are related to outcomes in patients with advanced heart failure awaiting heart transplantation. In: Journal of Cardiac Failure. 2013 ; Vol. 19, No. 4. pp. 240-250.
@article{40d226e9d80f43ab9662e9159f802cd3,
title = "Dietary habits are related to outcomes in patients with advanced heart failure awaiting heart transplantation",
abstract = "Background: Empirical evidence supporting the benefits of dietary recommendations for patients with advanced heart failure is scarce. We prospectively evaluated the relation of dietary habits to pre-transplant clinical outcomes in the multisite observational Waiting for a New Heart Study. Methods and Results: A total of 318 heart transplant candidates (82{\%} male, age 53 ± 11 years) completed a Food Frequency Questionnaire (foods high in salt, saturated fats, poly-/monounsaturated fats [PUFA+MUFA], fruit/vegetables/legumes, and fluid intake) at time of waitlisting. Cox proportional hazard models controlling for heart failure severity (eg, Heart Failure Survival Score, creatinine) estimated cause-specific hazard ratios (HRs) associated with each dietary habit individually, and with all dietary habits entered simultaneously. During follow-up (median 338 days, range 13-1,394), 54 patients died, 151 received transplants (110 in high-urgency status, 41 electively), and 45 became delisted (15 deteriorated, 30 improved). Two robust findings emerged: Frequent intake of salty foods, which correlated positively with saturated fat and fluid intake, was associated with transplantation in high-urgency status (HR 2.90, 95{\%} confidence interval [CI] 1.55-5.42); and frequent intake of foods rich in PUFA+MUFA reduced the risk for death/deterioration (HR 0.49, 95{\%} CI 0.26-0.92). Conclusions: These results support the importance of dietary habits for the prognosis of patients listed for heart transplantation, independently from heart failure severity.",
author = "Heike Spaderna and Daniela Zahn and Johanna Pretsch and Connor, {Sonja L.} and Armin Zittermann and {Schulze Schleithoff}, Stefanie and Bramstedt, {Katrina A.} and Smits, {Jacqueline M A} and Gerdi Weidner",
year = "2013",
month = "4",
doi = "10.1016/j.cardfail.2013.02.004",
language = "English",
volume = "19",
pages = "240--250",
journal = "Journal of Cardiac Failure",
issn = "1071-9164",
publisher = "Churchill Livingstone",
number = "4",

}

Spaderna, H, Zahn, D, Pretsch, J, Connor, SL, Zittermann, A, Schulze Schleithoff, S, Bramstedt, KA, Smits, JMA & Weidner, G 2013, 'Dietary habits are related to outcomes in patients with advanced heart failure awaiting heart transplantation' Journal of Cardiac Failure, vol. 19, no. 4, pp. 240-250. https://doi.org/10.1016/j.cardfail.2013.02.004

Dietary habits are related to outcomes in patients with advanced heart failure awaiting heart transplantation. / Spaderna, Heike; Zahn, Daniela; Pretsch, Johanna; Connor, Sonja L.; Zittermann, Armin; Schulze Schleithoff, Stefanie; Bramstedt, Katrina A.; Smits, Jacqueline M A; Weidner, Gerdi.

In: Journal of Cardiac Failure, Vol. 19, No. 4, 04.2013, p. 240-250.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Dietary habits are related to outcomes in patients with advanced heart failure awaiting heart transplantation

AU - Spaderna, Heike

AU - Zahn, Daniela

AU - Pretsch, Johanna

AU - Connor, Sonja L.

AU - Zittermann, Armin

AU - Schulze Schleithoff, Stefanie

AU - Bramstedt, Katrina A.

AU - Smits, Jacqueline M A

AU - Weidner, Gerdi

PY - 2013/4

Y1 - 2013/4

N2 - Background: Empirical evidence supporting the benefits of dietary recommendations for patients with advanced heart failure is scarce. We prospectively evaluated the relation of dietary habits to pre-transplant clinical outcomes in the multisite observational Waiting for a New Heart Study. Methods and Results: A total of 318 heart transplant candidates (82% male, age 53 ± 11 years) completed a Food Frequency Questionnaire (foods high in salt, saturated fats, poly-/monounsaturated fats [PUFA+MUFA], fruit/vegetables/legumes, and fluid intake) at time of waitlisting. Cox proportional hazard models controlling for heart failure severity (eg, Heart Failure Survival Score, creatinine) estimated cause-specific hazard ratios (HRs) associated with each dietary habit individually, and with all dietary habits entered simultaneously. During follow-up (median 338 days, range 13-1,394), 54 patients died, 151 received transplants (110 in high-urgency status, 41 electively), and 45 became delisted (15 deteriorated, 30 improved). Two robust findings emerged: Frequent intake of salty foods, which correlated positively with saturated fat and fluid intake, was associated with transplantation in high-urgency status (HR 2.90, 95% confidence interval [CI] 1.55-5.42); and frequent intake of foods rich in PUFA+MUFA reduced the risk for death/deterioration (HR 0.49, 95% CI 0.26-0.92). Conclusions: These results support the importance of dietary habits for the prognosis of patients listed for heart transplantation, independently from heart failure severity.

AB - Background: Empirical evidence supporting the benefits of dietary recommendations for patients with advanced heart failure is scarce. We prospectively evaluated the relation of dietary habits to pre-transplant clinical outcomes in the multisite observational Waiting for a New Heart Study. Methods and Results: A total of 318 heart transplant candidates (82% male, age 53 ± 11 years) completed a Food Frequency Questionnaire (foods high in salt, saturated fats, poly-/monounsaturated fats [PUFA+MUFA], fruit/vegetables/legumes, and fluid intake) at time of waitlisting. Cox proportional hazard models controlling for heart failure severity (eg, Heart Failure Survival Score, creatinine) estimated cause-specific hazard ratios (HRs) associated with each dietary habit individually, and with all dietary habits entered simultaneously. During follow-up (median 338 days, range 13-1,394), 54 patients died, 151 received transplants (110 in high-urgency status, 41 electively), and 45 became delisted (15 deteriorated, 30 improved). Two robust findings emerged: Frequent intake of salty foods, which correlated positively with saturated fat and fluid intake, was associated with transplantation in high-urgency status (HR 2.90, 95% confidence interval [CI] 1.55-5.42); and frequent intake of foods rich in PUFA+MUFA reduced the risk for death/deterioration (HR 0.49, 95% CI 0.26-0.92). Conclusions: These results support the importance of dietary habits for the prognosis of patients listed for heart transplantation, independently from heart failure severity.

UR - http://www.scopus.com/inward/record.url?scp=84876275949&partnerID=8YFLogxK

U2 - 10.1016/j.cardfail.2013.02.004

DO - 10.1016/j.cardfail.2013.02.004

M3 - Article

VL - 19

SP - 240

EP - 250

JO - Journal of Cardiac Failure

JF - Journal of Cardiac Failure

SN - 1071-9164

IS - 4

ER -