Dietary fibre modification with or without antibiotics in the prevention of diverticulitis in adults with diverticular disease: a systematic review and meta-analysis

Megan Crichton, Camilla Dahl, Julie Jenkins-Chapman, Romina Nucera, Wolfgang Marx, Skye Marshall

Research output: Contribution to conferencePosterResearch

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Abstract

Background: The use of high dietary fibre intake and antibiotics have been hypothesised to play a role in the management of diverticular disease; however, dietary recommendations for the prevention of diverticulitis in those with diverticular disease are inconsistent and quality evidence is lacking. Therefore, this systematic review aimed to pool and appraise existing data to explore the effect of dietary fibre modifications with or without antibiotics on the development of acute diverticulitis, gastrointestinal symptoms and bowel habits in adults with diverticular disease. Methods: Five electronic databases were searched for studies from database inception until March 2017. Studies were critically appraised and pooled using meta-analysis. Results: 20 studies were included. Compared with placebo, ispaghula husk supplementation significantly increased daily stool weight by μ42g/day (95%CI:26-57g; P<0.00001); however, dietary fibre supplementation inconsistently improved gastrointestinal symptoms and transit times depending on baseline values, and no studies evaluated its role in preventing diverticulitis. Seven days to everyday per month for 12-24-months of dietary fibre supplementation had a 2.6 (95%CI:1.24-5.6; P=0.01) higher relative risk of diverticulitis compared to dietary fibre and poorly-absorbed antibiotic coadministration. Seven days every month for 12-24-months or 14 days of dietary fibre and poorly-absorbed antibiotic co-administration significantly decreased gastrointestinal symptoms compared with dietary fibre supplementation alone by a standardised mean of 1 point (scale of 0 to approximately 18) (95%CI:0.70-1.21; P<0.00001). Conclusions: Dietary fibre supplementation may improve bowel function and gastrointestinal symptoms in those with diverticular disease; but its role in the prevention of diverticulitis is unknown. Although co-administration with poorly-absorbed antibiotics appears to have superior effects compared to dietary fibre supplementation alone; recommendations for this are not supported due to the high risk of bias in existing research.
Original languageEnglish
Publication statusPublished - Nov 2017
Event43rd Annual Scientific Meeting of the Australasian Society for Parenteral and Enteral Nutrition: Collaboration in Clinical Nutrition – Evidence Based Nutrition for Improving Patient Outcomes - Royal Pines Conference Centre, Gold Coast, Australia
Duration: 16 Nov 201718 Nov 2017
Conference number: 43rd

Conference

Conference43rd Annual Scientific Meeting of the Australasian Society for Parenteral and Enteral Nutrition
Abbreviated titleAuSPEN 2017
CountryAustralia
CityGold Coast
Period16/11/1718/11/17

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  • Projects

    Research by Master of Nutrition and Dietetic Practice Students

    Isenring, E., Marshall, S., Reidlinger, D., Kelly, J., Cox, G., Van der Meij, B., MacKenzie-Shalders, K., Mayr, H., Dahl, C., Crichton, M., O'Bryan, K. R., Norris, R., Warner, M., Davidson, A., Naranjo, A., Mahoney, S., Eberhardt, F., Dalwood, P., Lopez, E., Hofto, S., Innerarity, C. & So, D.

    1/01/1431/12/27

    Project: Research

    Bond University Nutrition and Dietetics Research Group Research Collaborations with External Clinical Partners

    Marshall, S., Isenring, E., MacKenzie-Shalders, K., Kelly, J., Campbell, K., Van der Meij, B., Cox, G., Reidlinger, D., Mayr, H., Banbury, M., Nucera, R., Jenkins, J., McCray, S., Canavan, R., Parker, B., de Groot, L., Cohen, F., Rich, G., Soni, A., McCarthy, A. L., Mackay, H., Young, A. M., Hickman, I., Wilkinson, S. A., Kiss, N. & Ali, A.

    1/01/14 → …

    Project: Research

    Nutrition Research for Digestive Health

    Marshall, S., Crichton, M., Campbell, K., Lohning, A., Marx, W., Van der Meij, B., Angus, R. & Canavan, R.

    1/01/14 → …

    Project: Research

    Activities

    • 1 Non-HDR Student Supervision

    Camilla Dahl - Masters of Nutrition and Dietetic Practice research project

    Skye Marshall (Supervisor)
    25 Sep 20161 May 2017

    Activity: Professional Development, Mentorship, Supervision and Other ActivitiesNon-HDR Student Supervision

    Cite this

    Crichton, M., Dahl, C., Jenkins-Chapman, J., Nucera, R., Marx, W., & Marshall, S. (2017). Dietary fibre modification with or without antibiotics in the prevention of diverticulitis in adults with diverticular disease: a systematic review and meta-analysis. Poster session presented at 43rd Annual Scientific Meeting of the Australasian Society for Parenteral and Enteral Nutrition, Gold Coast, Australia.