Diagnostic accuracy of cystatin C compared to serum creatinine for the estimation of renal dysfunction in adults and children: A meta-analysis

Juliana F Roos, Jenny Doust, Susan E Tett, Carl M J Kirkpatrick

Research output: Contribution to journalArticleResearch

242 Citations (Scopus)

Abstract

OBJECTIVES: To perform a systematic review comparing the diagnostic accuracy of CysC with SCr.

METHODS: MEDLINE and EMBASE (January 1984-February 2006) were searched. Studies included i) evaluated CysC against a recognised 'gold standard' method for determining GFR using a receiver operating characteristics (ROC) curve analysis and ii) included data that could be extracted into a 2x2 table.

RESULTS: The search identified 27 population groups in 24 studies (n=2007) that compared the diagnostic accuracy of CysC with SCr. The diagnostic odds ratios (DORs) (95% CI) of predicting renal dysfunction derived from a Moses-Littenberg linear regression model were 3.99 (3.41-4.57) for CysC and 2.79 (2.12-3.46) for SCr.

CONCLUSION: The diagnostic accuracy for impaired renal function favours CysC. However, the confidence intervals for the pooled DORs for the biomarkers overlap. The ability of CysC (cut-off values between 0.9 and 1.4 mg/L) to rule in renal impairment (as measured by inulin-determined GFR of 60-79 mL/min/1.73 m2) in persons in whom this is suspected is large and conclusive.

Original languageEnglish
Pages (from-to)383-91
Number of pages9
JournalClinical Biochemistry
Volume40
Issue number5-6
DOIs
Publication statusPublished - Mar 2007
Externally publishedYes

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Cystatin C
Inulin
Biomarkers
Linear regression
Meta-Analysis
Creatinine
Kidney
Linear Models
Serum
Odds Ratio
Population Groups
MEDLINE
ROC Curve
Confidence Intervals

Cite this

@article{18c8fab3d900409ca3521a90968715fa,
title = "Diagnostic accuracy of cystatin C compared to serum creatinine for the estimation of renal dysfunction in adults and children: A meta-analysis",
abstract = "OBJECTIVES: To perform a systematic review comparing the diagnostic accuracy of CysC with SCr.METHODS: MEDLINE and EMBASE (January 1984-February 2006) were searched. Studies included i) evaluated CysC against a recognised 'gold standard' method for determining GFR using a receiver operating characteristics (ROC) curve analysis and ii) included data that could be extracted into a 2x2 table.RESULTS: The search identified 27 population groups in 24 studies (n=2007) that compared the diagnostic accuracy of CysC with SCr. The diagnostic odds ratios (DORs) (95{\%} CI) of predicting renal dysfunction derived from a Moses-Littenberg linear regression model were 3.99 (3.41-4.57) for CysC and 2.79 (2.12-3.46) for SCr.CONCLUSION: The diagnostic accuracy for impaired renal function favours CysC. However, the confidence intervals for the pooled DORs for the biomarkers overlap. The ability of CysC (cut-off values between 0.9 and 1.4 mg/L) to rule in renal impairment (as measured by inulin-determined GFR of 60-79 mL/min/1.73 m2) in persons in whom this is suspected is large and conclusive.",
author = "Roos, {Juliana F} and Jenny Doust and Tett, {Susan E} and Kirkpatrick, {Carl M J}",
year = "2007",
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language = "English",
volume = "40",
pages = "383--91",
journal = "Clinical Biochemistry",
issn = "0009-9120",
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Diagnostic accuracy of cystatin C compared to serum creatinine for the estimation of renal dysfunction in adults and children : A meta-analysis. / Roos, Juliana F; Doust, Jenny; Tett, Susan E; Kirkpatrick, Carl M J.

In: Clinical Biochemistry, Vol. 40, No. 5-6, 03.2007, p. 383-91.

Research output: Contribution to journalArticleResearch

TY - JOUR

T1 - Diagnostic accuracy of cystatin C compared to serum creatinine for the estimation of renal dysfunction in adults and children

T2 - A meta-analysis

AU - Roos, Juliana F

AU - Doust, Jenny

AU - Tett, Susan E

AU - Kirkpatrick, Carl M J

PY - 2007/3

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N2 - OBJECTIVES: To perform a systematic review comparing the diagnostic accuracy of CysC with SCr.METHODS: MEDLINE and EMBASE (January 1984-February 2006) were searched. Studies included i) evaluated CysC against a recognised 'gold standard' method for determining GFR using a receiver operating characteristics (ROC) curve analysis and ii) included data that could be extracted into a 2x2 table.RESULTS: The search identified 27 population groups in 24 studies (n=2007) that compared the diagnostic accuracy of CysC with SCr. The diagnostic odds ratios (DORs) (95% CI) of predicting renal dysfunction derived from a Moses-Littenberg linear regression model were 3.99 (3.41-4.57) for CysC and 2.79 (2.12-3.46) for SCr.CONCLUSION: The diagnostic accuracy for impaired renal function favours CysC. However, the confidence intervals for the pooled DORs for the biomarkers overlap. The ability of CysC (cut-off values between 0.9 and 1.4 mg/L) to rule in renal impairment (as measured by inulin-determined GFR of 60-79 mL/min/1.73 m2) in persons in whom this is suspected is large and conclusive.

AB - OBJECTIVES: To perform a systematic review comparing the diagnostic accuracy of CysC with SCr.METHODS: MEDLINE and EMBASE (January 1984-February 2006) were searched. Studies included i) evaluated CysC against a recognised 'gold standard' method for determining GFR using a receiver operating characteristics (ROC) curve analysis and ii) included data that could be extracted into a 2x2 table.RESULTS: The search identified 27 population groups in 24 studies (n=2007) that compared the diagnostic accuracy of CysC with SCr. The diagnostic odds ratios (DORs) (95% CI) of predicting renal dysfunction derived from a Moses-Littenberg linear regression model were 3.99 (3.41-4.57) for CysC and 2.79 (2.12-3.46) for SCr.CONCLUSION: The diagnostic accuracy for impaired renal function favours CysC. However, the confidence intervals for the pooled DORs for the biomarkers overlap. The ability of CysC (cut-off values between 0.9 and 1.4 mg/L) to rule in renal impairment (as measured by inulin-determined GFR of 60-79 mL/min/1.73 m2) in persons in whom this is suspected is large and conclusive.

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JO - Clinical Biochemistry

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SN - 0009-9120

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