Diagnostic accuracy of cystatin C compared to serum creatinine for the estimation of renal dysfunction in adults and children: A meta-analysis

Juliana F Roos; Jenny Doust; Susan E Tett; Carl M J Kirkpatrick

doi:10.1016/j.clinbiochem.2006.10.026

Diagnostic accuracy of cystatin C compared to serum creatinine for the estimation of renal dysfunction in adults and children: A meta-analysis

Juliana F Roos, Jenny Doust, Susan E Tett, Carl M J Kirkpatrick

Research output: Contribution to journal › Article › Research

331 Citations (Scopus)

Abstract

OBJECTIVES: To perform a systematic review comparing the diagnostic accuracy of CysC with SCr.

METHODS: MEDLINE and EMBASE (January 1984-February 2006) were searched. Studies included i) evaluated CysC against a recognised 'gold standard' method for determining GFR using a receiver operating characteristics (ROC) curve analysis and ii) included data that could be extracted into a 2x2 table.

RESULTS: The search identified 27 population groups in 24 studies (n=2007) that compared the diagnostic accuracy of CysC with SCr. The diagnostic odds ratios (DORs) (95% CI) of predicting renal dysfunction derived from a Moses-Littenberg linear regression model were 3.99 (3.41-4.57) for CysC and 2.79 (2.12-3.46) for SCr.

CONCLUSION: The diagnostic accuracy for impaired renal function favours CysC. However, the confidence intervals for the pooled DORs for the biomarkers overlap. The ability of CysC (cut-off values between 0.9 and 1.4 mg/L) to rule in renal impairment (as measured by inulin-determined GFR of 60-79 mL/min/1.73 m2) in persons in whom this is suspected is large and conclusive.

Original language	English
Pages (from-to)	383-91
Number of pages	9
Journal	Clinical Biochemistry
Volume	40
Issue number	5-6
DOIs	https://doi.org/10.1016/j.clinbiochem.2006.10.026
Publication status	Published - Mar 2007
Externally published	Yes

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@article{18c8fab3d900409ca3521a90968715fa,

title = "Diagnostic accuracy of cystatin C compared to serum creatinine for the estimation of renal dysfunction in adults and children: A meta-analysis",

abstract = "OBJECTIVES: To perform a systematic review comparing the diagnostic accuracy of CysC with SCr.METHODS: MEDLINE and EMBASE (January 1984-February 2006) were searched. Studies included i) evaluated CysC against a recognised 'gold standard' method for determining GFR using a receiver operating characteristics (ROC) curve analysis and ii) included data that could be extracted into a 2x2 table.RESULTS: The search identified 27 population groups in 24 studies (n=2007) that compared the diagnostic accuracy of CysC with SCr. The diagnostic odds ratios (DORs) (95% CI) of predicting renal dysfunction derived from a Moses-Littenberg linear regression model were 3.99 (3.41-4.57) for CysC and 2.79 (2.12-3.46) for SCr.CONCLUSION: The diagnostic accuracy for impaired renal function favours CysC. However, the confidence intervals for the pooled DORs for the biomarkers overlap. The ability of CysC (cut-off values between 0.9 and 1.4 mg/L) to rule in renal impairment (as measured by inulin-determined GFR of 60-79 mL/min/1.73 m2) in persons in whom this is suspected is large and conclusive.",

author = "Roos, {Juliana F} and Jenny Doust and Tett, {Susan E} and Kirkpatrick, {Carl M J}",

year = "2007",

month = mar,

doi = "10.1016/j.clinbiochem.2006.10.026",

language = "English",

volume = "40",

pages = "383--91",

journal = "Clinical Biochemistry",

issn = "0009-9120",

publisher = "Elsevier",

number = "5-6",

}

TY - JOUR

T1 - Diagnostic accuracy of cystatin C compared to serum creatinine for the estimation of renal dysfunction in adults and children

T2 - A meta-analysis

AU - Roos, Juliana F

AU - Doust, Jenny

AU - Tett, Susan E

AU - Kirkpatrick, Carl M J

PY - 2007/3

Y1 - 2007/3

N2 - OBJECTIVES: To perform a systematic review comparing the diagnostic accuracy of CysC with SCr.METHODS: MEDLINE and EMBASE (January 1984-February 2006) were searched. Studies included i) evaluated CysC against a recognised 'gold standard' method for determining GFR using a receiver operating characteristics (ROC) curve analysis and ii) included data that could be extracted into a 2x2 table.RESULTS: The search identified 27 population groups in 24 studies (n=2007) that compared the diagnostic accuracy of CysC with SCr. The diagnostic odds ratios (DORs) (95% CI) of predicting renal dysfunction derived from a Moses-Littenberg linear regression model were 3.99 (3.41-4.57) for CysC and 2.79 (2.12-3.46) for SCr.CONCLUSION: The diagnostic accuracy for impaired renal function favours CysC. However, the confidence intervals for the pooled DORs for the biomarkers overlap. The ability of CysC (cut-off values between 0.9 and 1.4 mg/L) to rule in renal impairment (as measured by inulin-determined GFR of 60-79 mL/min/1.73 m2) in persons in whom this is suspected is large and conclusive.

AB - OBJECTIVES: To perform a systematic review comparing the diagnostic accuracy of CysC with SCr.METHODS: MEDLINE and EMBASE (January 1984-February 2006) were searched. Studies included i) evaluated CysC against a recognised 'gold standard' method for determining GFR using a receiver operating characteristics (ROC) curve analysis and ii) included data that could be extracted into a 2x2 table.RESULTS: The search identified 27 population groups in 24 studies (n=2007) that compared the diagnostic accuracy of CysC with SCr. The diagnostic odds ratios (DORs) (95% CI) of predicting renal dysfunction derived from a Moses-Littenberg linear regression model were 3.99 (3.41-4.57) for CysC and 2.79 (2.12-3.46) for SCr.CONCLUSION: The diagnostic accuracy for impaired renal function favours CysC. However, the confidence intervals for the pooled DORs for the biomarkers overlap. The ability of CysC (cut-off values between 0.9 and 1.4 mg/L) to rule in renal impairment (as measured by inulin-determined GFR of 60-79 mL/min/1.73 m2) in persons in whom this is suspected is large and conclusive.

UR - https://www.ncbi.nlm.nih.gov/pubmed/17316593

U2 - 10.1016/j.clinbiochem.2006.10.026

DO - 10.1016/j.clinbiochem.2006.10.026

M3 - Article

C2 - 17316593

SN - 0009-9120

VL - 40

SP - 383

EP - 391

JO - Clinical Biochemistry

JF - Clinical Biochemistry

IS - 5-6

ER -

Diagnostic accuracy of cystatin C compared to serum creatinine for the estimation of renal dysfunction in adults and children: A meta-analysis

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