This study analyzed socio-economic factors that influence farmers’ adaptation to climate change in agriculture. Perceptions regarding long-term changes in climate variables and the rate of occurrence of weather extremes were also investigated. Additionally, farmers’ perceived barriers to the use of adaptation practices were identified and ranked. A total of 100 farm-households were randomly selected from four communities in the Lawra district of Ghana and data were collected through semi-structured questionnaires, focused group discussions and field observations. A logistic regression model and weighted average index were used to analyze the data. The results showed that 87 % of respondents perceived a decrease in rainfall amount, while 82 % perceived an increase in temperature over the past 10 years. Results of the weighted average index indicate that dry spell and drought have a higher annual rate of occurrence than flood. Empirical results of the logistic regression model showed that education, household size, annual household income, access to information, credit and membership of farmer-based organization are the most important factors that influence farmers’ adaptation to climate change. The main constraints on adaptation include unpredictability of weather, high farm input cost, lack of access to timely weather information and water resources. The policy implication of this study is that governments should mainstream barriers to, and choice factors of, adaptation practices to climate change related projects and programs.