Desensitisation of urethral smooth muscle: Interaction between adrenoceptor and muscarinic receptor mediated pathways

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Abstract

Hypothesis / aims of study
Alpha1-adrenoceptor agonists have been suggested as a possible treatment for urinary stress incontinence, but no compound acting via this mechanism has yet been developed to the clinical stage. One possible explanation for this lack of success in drug development is desensitisation of the urethral smooth muscle by the agonist itself. Previous studies have shown that incubation with an α1-adrenoceptor agonist induces desensitisation of the porcine urethra (1). The urethra is dually innervated by both the sympathetic and parasympathetic divisions of the autonomic nervous system, and interaction of these two facets has been shown previously at the presynaptic level (2). Postsynaptic interaction between the parasympathetic and sympathetic nervous system is yet to be reported in the urethra. Aim of study: To investigate the effect of prior incubation with an adrenoceptor agonist on muscarinic receptor-mediated contractile responses of the porcine urethra, and vice versa.
Original languageEnglish
Article number470
Pages (from-to)S374-S375
Number of pages2
JournalNeurourology and Urodynamics
Volume34
Issue numberS3
DOIs
Publication statusPublished - Aug 2015
Event45th Annual Meeting of the International-Continence-Society (ICS) - Montreal, Canada
Duration: 6 Oct 20159 Oct 2015

Cite this

@article{973968c3010c41d6b86e889764ff7946,
title = "Desensitisation of urethral smooth muscle: Interaction between adrenoceptor and muscarinic receptor mediated pathways",
abstract = "Hypothesis / aims of study Alpha1-adrenoceptor agonists have been suggested as a possible treatment for urinary stress incontinence, but no compound acting via this mechanism has yet been developed to the clinical stage. One possible explanation for this lack of success in drug development is desensitisation of the urethral smooth muscle by the agonist itself. Previous studies have shown that incubation with an α1-adrenoceptor agonist induces desensitisation of the porcine urethra (1). The urethra is dually innervated by both the sympathetic and parasympathetic divisions of the autonomic nervous system, and interaction of these two facets has been shown previously at the presynaptic level (2). Postsynaptic interaction between the parasympathetic and sympathetic nervous system is yet to be reported in the urethra. Aim of study: To investigate the effect of prior incubation with an adrenoceptor agonist on muscarinic receptor-mediated contractile responses of the porcine urethra, and vice versa.",
author = "O. Folasire and D. Sellers and R. Chess-Williams",
year = "2015",
month = "8",
doi = "10.1002/nau.22830",
language = "English",
volume = "34",
pages = "S374--S375",
journal = "Neurourology and Urodynamics",
issn = "0733-2467",
publisher = "Wiley-Liss Inc.",
number = "S3",

}

Desensitisation of urethral smooth muscle : Interaction between adrenoceptor and muscarinic receptor mediated pathways. / Folasire, O.; Sellers, D.; Chess-Williams, R.

In: Neurourology and Urodynamics, Vol. 34, No. S3, 470, 08.2015, p. S374-S375.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

TY - JOUR

T1 - Desensitisation of urethral smooth muscle

T2 - Interaction between adrenoceptor and muscarinic receptor mediated pathways

AU - Folasire, O.

AU - Sellers, D.

AU - Chess-Williams, R.

PY - 2015/8

Y1 - 2015/8

N2 - Hypothesis / aims of study Alpha1-adrenoceptor agonists have been suggested as a possible treatment for urinary stress incontinence, but no compound acting via this mechanism has yet been developed to the clinical stage. One possible explanation for this lack of success in drug development is desensitisation of the urethral smooth muscle by the agonist itself. Previous studies have shown that incubation with an α1-adrenoceptor agonist induces desensitisation of the porcine urethra (1). The urethra is dually innervated by both the sympathetic and parasympathetic divisions of the autonomic nervous system, and interaction of these two facets has been shown previously at the presynaptic level (2). Postsynaptic interaction between the parasympathetic and sympathetic nervous system is yet to be reported in the urethra. Aim of study: To investigate the effect of prior incubation with an adrenoceptor agonist on muscarinic receptor-mediated contractile responses of the porcine urethra, and vice versa.

AB - Hypothesis / aims of study Alpha1-adrenoceptor agonists have been suggested as a possible treatment for urinary stress incontinence, but no compound acting via this mechanism has yet been developed to the clinical stage. One possible explanation for this lack of success in drug development is desensitisation of the urethral smooth muscle by the agonist itself. Previous studies have shown that incubation with an α1-adrenoceptor agonist induces desensitisation of the porcine urethra (1). The urethra is dually innervated by both the sympathetic and parasympathetic divisions of the autonomic nervous system, and interaction of these two facets has been shown previously at the presynaptic level (2). Postsynaptic interaction between the parasympathetic and sympathetic nervous system is yet to be reported in the urethra. Aim of study: To investigate the effect of prior incubation with an adrenoceptor agonist on muscarinic receptor-mediated contractile responses of the porcine urethra, and vice versa.

U2 - 10.1002/nau.22830

DO - 10.1002/nau.22830

M3 - Meeting Abstract

VL - 34

SP - S374-S375

JO - Neurourology and Urodynamics

JF - Neurourology and Urodynamics

SN - 0733-2467

IS - S3

M1 - 470

ER -