Abstract
Hypothesis / aims of study
Alpha1-adrenoceptor agonists have been suggested as a possible treatment for urinary stress incontinence, but no compound acting via this mechanism has yet been developed to the clinical stage. One possible explanation for this lack of success in drug development is desensitisation of the urethral smooth muscle by the agonist itself. Previous studies have shown that incubation with an α1-adrenoceptor agonist induces desensitisation of the porcine urethra (1). The urethra is dually innervated by both the sympathetic and parasympathetic divisions of the autonomic nervous system, and interaction of these two facets has been shown previously at the presynaptic level (2). Postsynaptic interaction between the parasympathetic and sympathetic nervous system is yet to be reported in the urethra. Aim of study: To investigate the effect of prior incubation with an adrenoceptor agonist on muscarinic receptor-mediated contractile responses of the porcine urethra, and vice versa.
Alpha1-adrenoceptor agonists have been suggested as a possible treatment for urinary stress incontinence, but no compound acting via this mechanism has yet been developed to the clinical stage. One possible explanation for this lack of success in drug development is desensitisation of the urethral smooth muscle by the agonist itself. Previous studies have shown that incubation with an α1-adrenoceptor agonist induces desensitisation of the porcine urethra (1). The urethra is dually innervated by both the sympathetic and parasympathetic divisions of the autonomic nervous system, and interaction of these two facets has been shown previously at the presynaptic level (2). Postsynaptic interaction between the parasympathetic and sympathetic nervous system is yet to be reported in the urethra. Aim of study: To investigate the effect of prior incubation with an adrenoceptor agonist on muscarinic receptor-mediated contractile responses of the porcine urethra, and vice versa.
| Original language | English |
|---|---|
| Article number | 470 |
| Pages (from-to) | S374-S375 |
| Number of pages | 2 |
| Journal | Neurourology and Urodynamics |
| Volume | 34 |
| Issue number | S3 |
| DOIs | |
| Publication status | Published - Aug 2015 |
| Event | 45th Annual Meeting of the International-Continence-Society (ICS) - Montreal, Canada Duration: 6 Oct 2015 → 9 Oct 2015 |
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Dive into the research topics of 'Desensitisation of urethral smooth muscle: Interaction between adrenoceptor and muscarinic receptor mediated pathways'. Together they form a unique fingerprint.Student theses
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Drug targets for urinary and faecal incontinence and anal fissures
Author: Folasire, O., 11 Feb 2017Supervisor: Sellers, D. J. (Supervisor) & Chess-Williams, R. G. (Supervisor)
Student thesis: Doctoral Thesis
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