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Methods: In 16 patients with solid tumours (C) and 16 age and gender matched healthy controls, the rates of appearance (Ra) and clearance of TRP were assessed by primed continuous infusion of L-[indole-2H5]TRP. Plasma amino acid profile was analyzed to measure plasma TRP level, and ratio plasma TRP to Large neutral amino acids (LNAA = sum of tyrosine, phenylalanine, isoleucine, leucine and valine) calculated as marker of TRP uptake into the brain. Mood was assessed by the
Hospital Anxiety and Depression Score, and cognition by a test battery consisting of the Auditory Verbal Learning, Verbal Fluency, Trail Making, and Stroop tests. Plasma amino acid levels and isotope enrichments were measured by LC-MS/MS. Statistics were done by unpaired t-tests and Pearson’s correlation.
Results: Depression scores were higher in C (5.0 vs 2.6, P<0.05), but cognitive outcomes were comparable between the groups. In C, the depression scores correlated negatively with plasma TRP (r=-0.69, P<0.01) and positively with TRP clearance rate (r=0.60, P<0.05). Additionally, we found that only in C, TRP Ra was associated with word fluency (r=0.70, P<0.01), processing speed (TMT completion time; r<-0.54, P<0.05), and verbal learning capacity and memory (immediate and delayed recall, learning rate and recognition; r≥0.63, P≤0.01). No relationship was found between plasma TRP/LNAA ratio and mood or cognition.
Conclusion: These findings suggest that an imbalance in TRP metabolism plays a role in the depressive symptoms in patients with cancer and may increase their risk of developing cognitive deficits.
|Number of pages||1|
|Publication status||Published - Sep 2017|
|Event||The 39th European Society for Clinical Nutrition and Metabolism Congress 2017 - Hague, Netherlands|
Duration: 9 Sep 2017 → 12 Sep 2017
Conference number: 39
Increased amino acid turnover and myofibrillar protein breakdown in advanced cancer are associated with decreased muscle strength and physical functionVan der Meij, B. S., Deutz, N., Rodriguez, R., Koeman, F., Smit, T. & Engelen, M., Sep 2017, In: Clinical Nutrition. 36, Supplement 1, p. S46-S47 2 p.
Research output: Contribution to journal › Meeting Abstract › Research › peer-review
Metabolic phenotyping to provide insight in mechanisms underlying muscle weakness and wasting in patients with cancerVan der Meij, B. S., Deutz, N., Rodriguez, R., Koeman, F., Smit, T. & Engelen, M., Sep 2017, In: Clinical Nutrition. 36, S1, p. S156
Research output: Contribution to journal › Meeting Abstract › Research › peer-reviewOpen Access