Dendritic cells as immune regulators: The mouse model

K. L. Griffiths, H. C. O'Neill

Research output: Contribution to journalReview articleResearchpeer-review

16 Citations (Scopus)
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Abstract

Dendritic cells (DC) are central to the immune system because of their role in antigen presentation leading to either tolerance or immunity among cells of the adaptive immune response. It is becoming increasingly evident that DC show extensive plasticity in terms of their origin and function, giving rise to a number of subsets represented differentially in all lymphoid organs. This article considers the tolerogenic capacity of murine DC and draws a distinction between DC that induce tolerance in the immature state and immunity in an inflammatory context, and those that act as regulatory cells inducing immunosuppression in the presence of inflammation.

Original languageEnglish
Pages (from-to)1909-1914
Number of pages6
JournalJournal of Cellular and Molecular Medicine
Volume12
Issue number5B
DOIs
Publication statusPublished - Oct 2008
Externally publishedYes

Cite this

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Dendritic cells as immune regulators : The mouse model. / Griffiths, K. L.; O'Neill, H. C.

In: Journal of Cellular and Molecular Medicine, Vol. 12, No. 5B, 10.2008, p. 1909-1914.

Research output: Contribution to journalReview articleResearchpeer-review

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AB - Dendritic cells (DC) are central to the immune system because of their role in antigen presentation leading to either tolerance or immunity among cells of the adaptive immune response. It is becoming increasingly evident that DC show extensive plasticity in terms of their origin and function, giving rise to a number of subsets represented differentially in all lymphoid organs. This article considers the tolerogenic capacity of murine DC and draws a distinction between DC that induce tolerance in the immature state and immunity in an inflammatory context, and those that act as regulatory cells inducing immunosuppression in the presence of inflammation.

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DO - 10.1111/j.1582-4934.2008.00378.x

M3 - Review article

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JO - Journal of Cellular and Molecular Medicine

JF - Journal of Cellular and Molecular Medicine

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