Dendritic cell development in the context of the spleen microenvironment

Research output: Contribution to journalReview articleResearchpeer-review

26 Citations (Scopus)

Abstract

The dendritic cell (DC) population in spleen comprises a mixture of cells including endogenous DC progenitors, DC precursors migrating in from blood and bone marrow, and DC in different states of differentiation and activation. A role for different microenvironments in supporting the dynamic development of murine DC of different types or lineages is considered here. Recent evidence for production of DC dependent on splenic stromal cells is reviewed in the light of evidence that cell production is dependent on cells comprising an endothelial niche in spleen. The possibility that self-renewing progenitors in spleen give rise to DC with tolerogeme or regulatory rather than immunostimulatory function is considered.

Original languageEnglish
Pages (from-to)2139-2145
Number of pages7
JournalStem Cells
Volume25
Issue number9
DOIs
Publication statusPublished - Sep 2007
Externally publishedYes

Cite this

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title = "Dendritic cell development in the context of the spleen microenvironment",
abstract = "The dendritic cell (DC) population in spleen comprises a mixture of cells including endogenous DC progenitors, DC precursors migrating in from blood and bone marrow, and DC in different states of differentiation and activation. A role for different microenvironments in supporting the dynamic development of murine DC of different types or lineages is considered here. Recent evidence for production of DC dependent on splenic stromal cells is reviewed in the light of evidence that cell production is dependent on cells comprising an endothelial niche in spleen. The possibility that self-renewing progenitors in spleen give rise to DC with tolerogeme or regulatory rather than immunostimulatory function is considered.",
author = "Tan, {Jonathan K. H.} and O'Neill, {Helen C.}",
year = "2007",
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pages = "2139--2145",
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Dendritic cell development in the context of the spleen microenvironment. / Tan, Jonathan K. H.; O'Neill, Helen C.

In: Stem Cells, Vol. 25, No. 9, 09.2007, p. 2139-2145.

Research output: Contribution to journalReview articleResearchpeer-review

TY - JOUR

T1 - Dendritic cell development in the context of the spleen microenvironment

AU - Tan, Jonathan K. H.

AU - O'Neill, Helen C.

PY - 2007/9

Y1 - 2007/9

N2 - The dendritic cell (DC) population in spleen comprises a mixture of cells including endogenous DC progenitors, DC precursors migrating in from blood and bone marrow, and DC in different states of differentiation and activation. A role for different microenvironments in supporting the dynamic development of murine DC of different types or lineages is considered here. Recent evidence for production of DC dependent on splenic stromal cells is reviewed in the light of evidence that cell production is dependent on cells comprising an endothelial niche in spleen. The possibility that self-renewing progenitors in spleen give rise to DC with tolerogeme or regulatory rather than immunostimulatory function is considered.

AB - The dendritic cell (DC) population in spleen comprises a mixture of cells including endogenous DC progenitors, DC precursors migrating in from blood and bone marrow, and DC in different states of differentiation and activation. A role for different microenvironments in supporting the dynamic development of murine DC of different types or lineages is considered here. Recent evidence for production of DC dependent on splenic stromal cells is reviewed in the light of evidence that cell production is dependent on cells comprising an endothelial niche in spleen. The possibility that self-renewing progenitors in spleen give rise to DC with tolerogeme or regulatory rather than immunostimulatory function is considered.

U2 - 10.1634/stemcells.2007-C244

DO - 10.1634/stemcells.2007-C244

M3 - Review article

VL - 25

SP - 2139

EP - 2145

JO - International Journal of Cell Cloning

JF - International Journal of Cell Cloning

SN - 1066-5099

IS - 9

ER -