Delineation of niches which support hematopoiesis

Hong Lim, Helen C O'Neill

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

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Abstract

[Extract] Hematopoiesis is the process of blood cell formation from self-renewing, multipotent hematopoietic stem cells (HSC) crucial for blood homeostasis of all living organisms [1]. This developmental process has two distinct phases, primitive and definitive hematopoiesis. In mice, the primitive phase of hematopoiesis occurs in the yolk sac at embryonic (E) day 7.5 [2-5]. It results in the production of primitive hematopoietic cells including mainly large, nucleated erythroblasts, some megakaryocytes, and primitive macrophages needed for embryonic growth [2-5]. The definitive phase of hematopoiesis in mice begins in the extra-embryonic yolk sac at E8.25 [2, 6]. Development in this phase is a hierarchical process, with two main lymphoid and myeloid lineages forming from which all blood cells develop. The lymphoid lineage comprises T and B lymphocytes and natural killer cells that arise from a common lymphoid progenitor (CLP). In contrast, the myeloid lineage comprises granulocytes (neutrophils, eosinophils, mast cells, and basophils), monocytes, erythrocytes and dendritic cells (DC), all developing from a common myeloid progenitor (CMP). The multipotent HSC resides at the apex of this hematopoietic hierarchy.
Original languageEnglish
Title of host publicationAdult Stem Cell Niches
EditorsS Wislet-Gendebien
Place of PublicationCroatia
PublisherIn-Tech
Pages3-20
Number of pages18
ISBN (Electronic)978-953-51-1718-6
DOIs
Publication statusPublished - 2014

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Hematopoiesis
Multipotent Stem Cells
Yolk Sac
Hematopoietic Stem Cells
Blood Cells
Lymphoid Progenitor Cells
Myeloid Progenitor Cells
Erythroblasts
Megakaryocytes
Basophils
Granulocytes
Eosinophils
Mast Cells
Natural Killer Cells
Dendritic Cells
Monocytes
Neutrophils
Homeostasis
B-Lymphocytes
Erythrocytes

Cite this

Lim, H., & O'Neill, H. C. (2014). Delineation of niches which support hematopoiesis. In S. Wislet-Gendebien (Ed.), Adult Stem Cell Niches (pp. 3-20). Croatia: In-Tech. https://doi.org/10.5772/58715
Lim, Hong ; O'Neill, Helen C. / Delineation of niches which support hematopoiesis. Adult Stem Cell Niches. editor / S Wislet-Gendebien. Croatia : In-Tech, 2014. pp. 3-20
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Lim, H & O'Neill, HC 2014, Delineation of niches which support hematopoiesis. in S Wislet-Gendebien (ed.), Adult Stem Cell Niches. In-Tech, Croatia, pp. 3-20. https://doi.org/10.5772/58715

Delineation of niches which support hematopoiesis. / Lim, Hong; O'Neill, Helen C.

Adult Stem Cell Niches. ed. / S Wislet-Gendebien. Croatia : In-Tech, 2014. p. 3-20.

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

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Lim H, O'Neill HC. Delineation of niches which support hematopoiesis. In Wislet-Gendebien S, editor, Adult Stem Cell Niches. Croatia: In-Tech. 2014. p. 3-20 https://doi.org/10.5772/58715