DARPP-32 like protein in specific snail (Helix aspersa) neurones

N. N. Osborne*, N. L. Barnett, N. J. Morris

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review


Monoclonal antibodies to DARPP-32 recognise an antigen which is present in specific neurones in the snail (Helix aspersa). Consecutive sections 10-μm-thick processed for the localisation of DARPP-32 and tyrosine-hydroxylase immunoreactivity did not show a coexistence in any neuronal structures. DARPP-32 positive cells were, however, often morphologically closely associated with tyrosine-hydroxylase positive cells, implying a functional relationship consistent with the proposed role of DARPP-32. Immunochemical analysis of the DARPP-32 immunoreative material in the snail nervous system shows that the substance has a molecular weight of 28 kDa and therefore different from the DARPP-32 protein found in the rat brain.

Original languageEnglish
Pages (from-to)413-417
Number of pages5
Issue number4
Publication statusPublished - 1 Feb 1991
Externally publishedYes


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