Abstract
Aims
Cytoreductive surgery combined with perioperative intraperitoneal chemotherapy has been reported as a treatment option for patients with peritoneal carcinomatosis from colorectal carcinoma.
Methods
Thirty patients with colorectal peritoneal carcinomatosis underwent cytoreductive surgery and perioperative intraperitoneal chemotherapy. All appendiceal cancers were excluded. All patients were followed until January 2006 or death. Univariate analysis was performed to evaluate significant prognostic factors for overall survival, defined from the time of surgery.
Results
There were 13 male patients. The mean age at the time of surgery was 54 years. There was no hospital mortality. The mean duration of hospital stay was 27 days. The overall median survival was 29 months, with 1- and 2-year survival of 72% and 64%, respectively. Twenty-one patients had complete cytoreduction and their 1- and 2-year survival rates were 85% and 71%, respectively. Univariate analysis demonstrated that patients with non-mucinous colorectal adenocarcinoma, Peritoneal Cancer Index (PCI) ≤13, and complete cytoreduction were associated with an improved survival.
Conclusions
This study reported on 30 patients who underwent cytoreductive surgery and perioperative intraperitoneal chemotherapy for colorectal peritoneal carcinomatosis. Patients with mucinous tumour had relatively more extensive intraperitoneal disease. Non-mucinous colorectal adenocarcinoma, PCI ≤13, and complete cytoreduction were associated with an improved survival.
Cytoreductive surgery combined with perioperative intraperitoneal chemotherapy has been reported as a treatment option for patients with peritoneal carcinomatosis from colorectal carcinoma.
Methods
Thirty patients with colorectal peritoneal carcinomatosis underwent cytoreductive surgery and perioperative intraperitoneal chemotherapy. All appendiceal cancers were excluded. All patients were followed until January 2006 or death. Univariate analysis was performed to evaluate significant prognostic factors for overall survival, defined from the time of surgery.
Results
There were 13 male patients. The mean age at the time of surgery was 54 years. There was no hospital mortality. The mean duration of hospital stay was 27 days. The overall median survival was 29 months, with 1- and 2-year survival of 72% and 64%, respectively. Twenty-one patients had complete cytoreduction and their 1- and 2-year survival rates were 85% and 71%, respectively. Univariate analysis demonstrated that patients with non-mucinous colorectal adenocarcinoma, Peritoneal Cancer Index (PCI) ≤13, and complete cytoreduction were associated with an improved survival.
Conclusions
This study reported on 30 patients who underwent cytoreductive surgery and perioperative intraperitoneal chemotherapy for colorectal peritoneal carcinomatosis. Patients with mucinous tumour had relatively more extensive intraperitoneal disease. Non-mucinous colorectal adenocarcinoma, PCI ≤13, and complete cytoreduction were associated with an improved survival.
| Original language | English |
|---|---|
| Pages (from-to) | 1119-1124 |
| Number of pages | 6 |
| Journal | European Journal of Surgical Oncology |
| Volume | 32 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Dec 2006 |
| Externally published | Yes |
