Cytogenetics of basal cell and squamous cell carcinomas

Melanie A. Carless, Kevin John Ashton, Lyn R Griffiths

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

Abstract

Cytogenetic analysis is a powerful tool that allows analysis of chromosomal aberrations associated with diseased states. In particular, a combination of cytogenetic techniques has allowed the identification of aberrations associated with cancer development, including cancers of the skin. This chapter provides a comprehensive overview of cytogenetic alterations in basal and squamous cell carcinomas of the skin. These two distinct lesions have altered karyotypes that are consistent with their malignant potential. Basal cell carcinomas, although relatively stable lesions, are highly associated with recurrent aberrations of chromosomes 6, 7, 9 and X, as detected by a number of cytogenetic techniques. Squamous cell carcinomas, on the other hand are associated with a much higher degree of instability, involving aberrations of chromosomes 3, 7, 8, 11, 13, 17 and 18, as detected using a number of cytogenetic techniques. Overall, the numbers and types of aberrations associated with basal and squamous cell carcinoma, define the characteristic behaviour associated with these lesions and identification of these aberrations may aid in the understanding of malignant potential, prognosis and treatment of these skin cancers.
Original languageEnglish
Title of host publicationMolecular Mechanisms of Basal Cell and Squamous Cell Carcinomas
EditorsJorg Richrath
PublisherSpringer
Pages49-57
Number of pages9
ISBN (Electronic)978-0-387-35098-1
ISBN (Print)978-0-387-26046-4
DOIs
Publication statusPublished - 2006

Publication series

Name Medical Intelligence Unit

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    Carless, M. A., Ashton, K. J., & Griffiths, L. R. (2006). Cytogenetics of basal cell and squamous cell carcinomas. In J. Richrath (Ed.), Molecular Mechanisms of Basal Cell and Squamous Cell Carcinomas (pp. 49-57). ( Medical Intelligence Unit ). Springer. https://doi.org/10.1007/0-387-35098-5_6