Cutaneous markers of photo-damage and risk of Basal cell carcinoma of the skin: a meta-analysis

Mohammad Khalesi, David C. Whiteman, Suhail A R Doi, Justin Clark, Michael G Kimlin, Rachel E Neale

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Abstract

Epidemiologic research has shown that cutaneous markers of photo-damage are associated with risk of basal cell carcinoma (BCC). However, there has been no previous attempt to calculate pooled risk estimates. We conducted a systematic review and meta-analysis after extracting relevant studies published up to January 2013 from five electronic databases. Eligible studies were those that permitted quantitative assessment of the association between histologically confirmed BCC and actinic keratoses, solar elastosis, solar lentigines, or telangiectasia. Seven eligible studies were identified and summary odds ratios (ORs) were calculated using both random and quality effects models. Having more than ten actinic keratoses was most strongly associated with BCC, conferring up to a fivefold increase in risk (OR: 4.97; 95% CI: 3.26-7.58). Other factors, including solar elastosis, solar lentigines, and telangiectasia had weaker but positive associations with BCC with ORs around 1.5. Markers of chronic photo-damage are positively associated with BCC. The presence of actinic keratoses was the most strongly associated with BCC of the markers examined. This work highlights the relatively modest association between markers of chronic ultraviolet exposure and BCC.

Original languageEnglish
Pages (from-to)1483-9
Number of pages7
JournalCancer Epidemiology, Biomarkers and Prevention
Volume22
Issue number9
DOIs
Publication statusPublished - Sep 2013
Externally publishedYes

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Basal Cell Carcinoma
Meta-Analysis
Skin
Actinic Keratosis
Odds Ratio
Lentigo
Telangiectasis
Databases
Research

Cite this

Khalesi, Mohammad ; Whiteman, David C. ; Doi, Suhail A R ; Clark, Justin ; Kimlin, Michael G ; Neale, Rachel E. / Cutaneous markers of photo-damage and risk of Basal cell carcinoma of the skin : a meta-analysis. In: Cancer Epidemiology, Biomarkers and Prevention. 2013 ; Vol. 22, No. 9. pp. 1483-9.
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abstract = "Epidemiologic research has shown that cutaneous markers of photo-damage are associated with risk of basal cell carcinoma (BCC). However, there has been no previous attempt to calculate pooled risk estimates. We conducted a systematic review and meta-analysis after extracting relevant studies published up to January 2013 from five electronic databases. Eligible studies were those that permitted quantitative assessment of the association between histologically confirmed BCC and actinic keratoses, solar elastosis, solar lentigines, or telangiectasia. Seven eligible studies were identified and summary odds ratios (ORs) were calculated using both random and quality effects models. Having more than ten actinic keratoses was most strongly associated with BCC, conferring up to a fivefold increase in risk (OR: 4.97; 95{\%} CI: 3.26-7.58). Other factors, including solar elastosis, solar lentigines, and telangiectasia had weaker but positive associations with BCC with ORs around 1.5. Markers of chronic photo-damage are positively associated with BCC. The presence of actinic keratoses was the most strongly associated with BCC of the markers examined. This work highlights the relatively modest association between markers of chronic ultraviolet exposure and BCC.",
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Cutaneous markers of photo-damage and risk of Basal cell carcinoma of the skin : a meta-analysis. / Khalesi, Mohammad; Whiteman, David C.; Doi, Suhail A R; Clark, Justin; Kimlin, Michael G; Neale, Rachel E.

In: Cancer Epidemiology, Biomarkers and Prevention, Vol. 22, No. 9, 09.2013, p. 1483-9.

Research output: Contribution to journalArticleResearchpeer-review

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T2 - a meta-analysis

AU - Khalesi, Mohammad

AU - Whiteman, David C.

AU - Doi, Suhail A R

AU - Clark, Justin

AU - Kimlin, Michael G

AU - Neale, Rachel E

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AB - Epidemiologic research has shown that cutaneous markers of photo-damage are associated with risk of basal cell carcinoma (BCC). However, there has been no previous attempt to calculate pooled risk estimates. We conducted a systematic review and meta-analysis after extracting relevant studies published up to January 2013 from five electronic databases. Eligible studies were those that permitted quantitative assessment of the association between histologically confirmed BCC and actinic keratoses, solar elastosis, solar lentigines, or telangiectasia. Seven eligible studies were identified and summary odds ratios (ORs) were calculated using both random and quality effects models. Having more than ten actinic keratoses was most strongly associated with BCC, conferring up to a fivefold increase in risk (OR: 4.97; 95% CI: 3.26-7.58). Other factors, including solar elastosis, solar lentigines, and telangiectasia had weaker but positive associations with BCC with ORs around 1.5. Markers of chronic photo-damage are positively associated with BCC. The presence of actinic keratoses was the most strongly associated with BCC of the markers examined. This work highlights the relatively modest association between markers of chronic ultraviolet exposure and BCC.

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