Most existing cortico-hippocampal computational models use different artificial neural network topologies. These conventional approaches, which simulate various biological paradigms, can get slow training and inadequate conditioned responses for two reasons: increases in the number of conditioned stimuli and in the complexity of the simulated biological paradigms in different phases. In this paper, a cortico-hippocampal computational quantum (CHCQ) model is proposed for modeling intact and lesioned systems. The CHCQ model is the first computational model that uses the quantum neural networks for simulating the biological paradigms. The model consists of two entangled quantum neural networks: an adaptive single-layer feedforward quantum neural network and an autoencoder quantum neural network. The CHCQ model adaptively updates all the weights of its quantum neural networks using quantum instar, outstar, and Widrow–Hoff learning algorithms. Our model successfully simulated several biological processes and maintained the output-conditioned responses quickly and efficiently. Moreover, the results were consistent with prior biological studies.