Correlating motor and cognitive behaviour: Exploring the notion of akinetic and dyskinetic linguistic homologues

Bruce E. Murdoch, Brooke-Mai Whelan, Deborah Theodoros, Bruce Hall, Peter A. Silburn

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Abstract

In relation to motor control, the basal ganglia have been implicated
in both the scaling and focusing of movement by way of modulating
activity within the pallidothalamic arm of subcortical motor circuitry.
Requisite globus pallidus internus (GPi) activity thresholds reportedly
exist, above which hypokinetic motor signs emerge and below which
the manifestation of dyskinesia is observed. Cognitive-linguistic correlates
relative to overshooting and undershooting of GPi activity,
however, have not been coherently translated to date. The primary
objectives of the current research were thus, two-fold: (1) to describe
the nature of potential language deficits within akinetic and dyskinetic
neural systems, as defined by motor disturbances and (2) to investigate
the impact of surgically-induced GPi lesions upon linguistic behaviour.
This paper compares the linguistic profiles of 2 opposing Parkinsonian
cases with respect to primary motor symptom complex, subsequent to
bilateral posteroventral pallidotomy (BPVP). Subject 1 was a 73 year
old female with 10 years of formal education, a reported disease duration
of 11 years and an akinetic primary symptom complex. Subject
2 was a 70 year old male with 10 years of formal education, a reported
disease duration of 10 years and a dyskinetic primary symptom
complex.
Original languageEnglish
Pages (from-to)192-192
Number of pages1
JournalBrain and Language
Volume87
Issue number1
DOIs
Publication statusPublished - 14 Aug 2003
Externally publishedYes
Event41st Annual Meeting of the Academy of Aphasia - Vienna, Austria
Duration: 19 Oct 200321 Oct 2003
Conference number: 14st

Fingerprint

Globus Pallidus
Linguistics
cognition
linguistics
Pallidotomy
Education
Dyskinesias
Basal Ganglia
scaling
education
deficit
Language
Disease
language
Research
Formal Education

Cite this

Murdoch, Bruce E. ; Whelan, Brooke-Mai ; Theodoros, Deborah ; Hall, Bruce ; Silburn, Peter A. / Correlating motor and cognitive behaviour : Exploring the notion of akinetic and dyskinetic linguistic homologues. In: Brain and Language. 2003 ; Vol. 87, No. 1. pp. 192-192.
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title = "Correlating motor and cognitive behaviour: Exploring the notion of akinetic and dyskinetic linguistic homologues",
abstract = "In relation to motor control, the basal ganglia have been implicatedin both the scaling and focusing of movement by way of modulatingactivity within the pallidothalamic arm of subcortical motor circuitry.Requisite globus pallidus internus (GPi) activity thresholds reportedlyexist, above which hypokinetic motor signs emerge and below whichthe manifestation of dyskinesia is observed. Cognitive-linguistic correlatesrelative to overshooting and undershooting of GPi activity,however, have not been coherently translated to date. The primaryobjectives of the current research were thus, two-fold: (1) to describethe nature of potential language deficits within akinetic and dyskineticneural systems, as defined by motor disturbances and (2) to investigatethe impact of surgically-induced GPi lesions upon linguistic behaviour.This paper compares the linguistic profiles of 2 opposing Parkinsoniancases with respect to primary motor symptom complex, subsequent tobilateral posteroventral pallidotomy (BPVP). Subject 1 was a 73 yearold female with 10 years of formal education, a reported disease durationof 11 years and an akinetic primary symptom complex. Subject2 was a 70 year old male with 10 years of formal education, a reporteddisease duration of 10 years and a dyskinetic primary symptomcomplex.",
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Correlating motor and cognitive behaviour : Exploring the notion of akinetic and dyskinetic linguistic homologues. / Murdoch, Bruce E.; Whelan, Brooke-Mai; Theodoros, Deborah; Hall, Bruce; Silburn, Peter A.

In: Brain and Language, Vol. 87, No. 1, 14.08.2003, p. 192-192.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

TY - JOUR

T1 - Correlating motor and cognitive behaviour

T2 - Exploring the notion of akinetic and dyskinetic linguistic homologues

AU - Murdoch, Bruce E.

AU - Whelan, Brooke-Mai

AU - Theodoros, Deborah

AU - Hall, Bruce

AU - Silburn, Peter A.

PY - 2003/8/14

Y1 - 2003/8/14

N2 - In relation to motor control, the basal ganglia have been implicatedin both the scaling and focusing of movement by way of modulatingactivity within the pallidothalamic arm of subcortical motor circuitry.Requisite globus pallidus internus (GPi) activity thresholds reportedlyexist, above which hypokinetic motor signs emerge and below whichthe manifestation of dyskinesia is observed. Cognitive-linguistic correlatesrelative to overshooting and undershooting of GPi activity,however, have not been coherently translated to date. The primaryobjectives of the current research were thus, two-fold: (1) to describethe nature of potential language deficits within akinetic and dyskineticneural systems, as defined by motor disturbances and (2) to investigatethe impact of surgically-induced GPi lesions upon linguistic behaviour.This paper compares the linguistic profiles of 2 opposing Parkinsoniancases with respect to primary motor symptom complex, subsequent tobilateral posteroventral pallidotomy (BPVP). Subject 1 was a 73 yearold female with 10 years of formal education, a reported disease durationof 11 years and an akinetic primary symptom complex. Subject2 was a 70 year old male with 10 years of formal education, a reporteddisease duration of 10 years and a dyskinetic primary symptomcomplex.

AB - In relation to motor control, the basal ganglia have been implicatedin both the scaling and focusing of movement by way of modulatingactivity within the pallidothalamic arm of subcortical motor circuitry.Requisite globus pallidus internus (GPi) activity thresholds reportedlyexist, above which hypokinetic motor signs emerge and below whichthe manifestation of dyskinesia is observed. Cognitive-linguistic correlatesrelative to overshooting and undershooting of GPi activity,however, have not been coherently translated to date. The primaryobjectives of the current research were thus, two-fold: (1) to describethe nature of potential language deficits within akinetic and dyskineticneural systems, as defined by motor disturbances and (2) to investigatethe impact of surgically-induced GPi lesions upon linguistic behaviour.This paper compares the linguistic profiles of 2 opposing Parkinsoniancases with respect to primary motor symptom complex, subsequent tobilateral posteroventral pallidotomy (BPVP). Subject 1 was a 73 yearold female with 10 years of formal education, a reported disease durationof 11 years and an akinetic primary symptom complex. Subject2 was a 70 year old male with 10 years of formal education, a reporteddisease duration of 10 years and a dyskinetic primary symptomcomplex.

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