Contingency learning deficits and generalization in chronic unilateral hand pain patients

Ann Meulders, Daniel S Harvie, Jane K Bowering, Suzanne Caragianis, Johan W S Vlaeyen, G Lorimer Moseley

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

Abstract

Contingency learning, in particular the formation of danger beliefs, underpins conditioned fear and avoidance behavior, yet equally important is the formation of safety beliefs. That is, when threat beliefs and accompanying fear/avoidance spread to technically safe cues, it might cause disability. Indeed, such over generalization has been advanced as a trans-diagnostic pathologic marker, but it has not been investigated in chronic pain. Using a novel hand pain scenario contingency learning task, we tested the hypotheses that chronic hand pain patients demonstrate less differential pain expectancy judgments because of poor safety learning and demonstrate broader generalization gradients than healthy controls. Participants viewed digitized 3-dimensional hands in different postures presented in random order (conditioned stimulus [CS]) and rated the likelihood that a fictive patient would feel pain when moving the hand into that posture. Subsequently, the outcome (pain/no pain) was presented on the screen. One hand posture was followed by pain (CS+), another was not (CS-). Generalization was tested using novel hand postures (generalization stimuli) that varied in how similar they were to the original conditioned stimuli. Patients, but not healthy controls, demonstrated a contingency learning deficit determined by impaired safety learning, but not by exaggerated pain expectancy toward the CS+. Patients showed flatter, asymmetric generalization gradients than the healthy controls did, with higher pain expectancy for novel postures that were more similar to the original CS-. The results clearly uphold our hypotheses and suggest that contingency learning deficits might be important in the development and maintenance of the chronic pain-related disability.

PERSPECTIVE: Chronic hand pain patients demonstrate 1) reduced differential contingency learning determined by a lack of safety belief formation, but not by exaggerated threat belief formation, and 2) flatter, asymmetric generalization gradients than the healthy controls.

Original languageEnglish
Pages (from-to)1046-1056
Number of pages11
JournalPain Forum
Volume15
Issue number10
DOIs
Publication statusPublished - Oct 2014
Externally publishedYes

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Hand
Learning
Pain
Posture
Chronic Pain
Safety
Fear
Stimulus Generalization
Avoidance Learning
Generalization (Psychology)
Cues
Maintenance

Cite this

Meulders, A., Harvie, D. S., Bowering, J. K., Caragianis, S., Vlaeyen, J. W. S., & Moseley, G. L. (2014). Contingency learning deficits and generalization in chronic unilateral hand pain patients. Pain Forum, 15(10), 1046-1056. https://doi.org/10.1016/j.jpain.2014.07.005
Meulders, Ann ; Harvie, Daniel S ; Bowering, Jane K ; Caragianis, Suzanne ; Vlaeyen, Johan W S ; Moseley, G Lorimer. / Contingency learning deficits and generalization in chronic unilateral hand pain patients. In: Pain Forum. 2014 ; Vol. 15, No. 10. pp. 1046-1056.
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Meulders, A, Harvie, DS, Bowering, JK, Caragianis, S, Vlaeyen, JWS & Moseley, GL 2014, 'Contingency learning deficits and generalization in chronic unilateral hand pain patients' Pain Forum, vol. 15, no. 10, pp. 1046-1056. https://doi.org/10.1016/j.jpain.2014.07.005

Contingency learning deficits and generalization in chronic unilateral hand pain patients. / Meulders, Ann; Harvie, Daniel S; Bowering, Jane K; Caragianis, Suzanne; Vlaeyen, Johan W S; Moseley, G Lorimer.

In: Pain Forum, Vol. 15, No. 10, 10.2014, p. 1046-1056.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Moseley, G Lorimer

N1 - Copyright © 2014 American Pain Society. Published by Elsevier Inc. All rights reserved.

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N2 - Contingency learning, in particular the formation of danger beliefs, underpins conditioned fear and avoidance behavior, yet equally important is the formation of safety beliefs. That is, when threat beliefs and accompanying fear/avoidance spread to technically safe cues, it might cause disability. Indeed, such over generalization has been advanced as a trans-diagnostic pathologic marker, but it has not been investigated in chronic pain. Using a novel hand pain scenario contingency learning task, we tested the hypotheses that chronic hand pain patients demonstrate less differential pain expectancy judgments because of poor safety learning and demonstrate broader generalization gradients than healthy controls. Participants viewed digitized 3-dimensional hands in different postures presented in random order (conditioned stimulus [CS]) and rated the likelihood that a fictive patient would feel pain when moving the hand into that posture. Subsequently, the outcome (pain/no pain) was presented on the screen. One hand posture was followed by pain (CS+), another was not (CS-). Generalization was tested using novel hand postures (generalization stimuli) that varied in how similar they were to the original conditioned stimuli. Patients, but not healthy controls, demonstrated a contingency learning deficit determined by impaired safety learning, but not by exaggerated pain expectancy toward the CS+. Patients showed flatter, asymmetric generalization gradients than the healthy controls did, with higher pain expectancy for novel postures that were more similar to the original CS-. The results clearly uphold our hypotheses and suggest that contingency learning deficits might be important in the development and maintenance of the chronic pain-related disability.PERSPECTIVE: Chronic hand pain patients demonstrate 1) reduced differential contingency learning determined by a lack of safety belief formation, but not by exaggerated threat belief formation, and 2) flatter, asymmetric generalization gradients than the healthy controls.

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Meulders A, Harvie DS, Bowering JK, Caragianis S, Vlaeyen JWS, Moseley GL. Contingency learning deficits and generalization in chronic unilateral hand pain patients. Pain Forum. 2014 Oct;15(10):1046-1056. https://doi.org/10.1016/j.jpain.2014.07.005